LSU Tigers vs Ole Miss Rebels Prediction, 9/27/2025 College Football Picks, Best Bets & Odds

Game: LSU Tigers vs Ole Miss Rebels

Date: Saturday, September 27, 2025

Location: Vaught-Hemingway Stadium in Oxford, MS

TV: ABC

Odds/Point Spread: Rebels (-2.5)

Total/Over-Under: 55.5

The LSU Tigers (4-0) are headed to Vaught-Hemingway Stadium on Saturday, September 27, 2025 where they will go up against the Ole Miss Rebels (4-0). LSU opens this contest as 2.5-point dogs. The total is 55.5.

The LSU Tigers come into this game with a record of 4-0 for this season. In their last game, the Tigers took the field against the Southeastern Louisiana Lions and took home the win by a score of 56-10. The LSU Tigers rushed the ball a total of 35 times and totaled 135 yards, which came out to an average of 3.9 yards per carry. Overall, they tallied 78 plays which gave them 530 yds. LSU conceded 11 completions on 21 tries for 116 yards, and a completion rate of 52.4%. When it came to stopping the run, the Tigers conceded 88 yds on 26 attempts, which is an average of 3.4 yards per rush allowed.

The Tigers have racked up 1,567 total yards for the year. When it comes to notching touchdowns, LSU has compiled 7 passing touchdowns and 6 touchdowns via the ground. They have turned the ball over 4 times. LSU has accumulated 94 first downs, and they have been called for 29 infractions for 240 yds. As a unit they're averaging 116.8 yards in the run game which is 112th in the nation. In terms of scoring points, the LSU Tigers hold an average of 29.0 points per game.

The Tigers are ranked 10th in the nation in terms of team defense, conceding 9.3 points per game. They are allowing teams to run for an average of 2.6 yards per rushing attempt and 64.0 rushing yards per game for the season. During the season, they have conceded 256 running yards through 4 games. When talking about passing yardage, the Tigers have given up 729 yds which puts them in 61st in D-1. They are allowing 182.3 yards per game through the air and allowed a completion percentage of 58.2%. For the season, they have allowed 246.3 yards per contest ranking them 20th in Division 1. They have given up 3 touchdowns via the pass and 1 touchdown running the ball.

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The Rebels head into this game 4-0 this year. When they last stepped on the gridiron, the Rebels got the victory with a final of 45-10 when they played the Tulane Green Wave. Ole Miss rushed for 5.7 yds per attempt, finishing with a total of 241 yards on 42 carries. The Rebels finished the contest with a total of 548 yds on 69 plays (7.9 yds per play). The Rebels pass defense allowed a completion percentage of 34.5%, surrendering 104 yds on 10 out of 29 through the air. Ole Miss allowed 39 attempts on the ground for 178 yards (4.6 yards per rush).

The Ole Miss Rebels are averaging 543.3 yards/game, which has them sitting 9th in D-1. The Ole Miss offense has racked up 235 penalty yards on 25 violations, which ranks 50th in the country in terms of helping out the opposition. They hold an average of 218.5 run yards per game and have toted the ball for 874 yards overall. They have thrown 4 picks while allowing opponents to recover 1 fumble and they have obtained 102 first downs. When discussing their ability to score points, the Rebels rank 12th in college football holding an average of 44.8 PPG. For the season to this point, the Rebels have compiled 1,299 yards via the pass as well as an average of 324.8 throwing yards per contest, which has them sitting 14th in the nation.

Ole Miss has allowed a total of 762 yards rushing (190.5 yards per outing) and 6 touchdowns via the rush for the season. They have allowed 3 touchdowns from the passing game as well as 166.3 yards per contest, which has them ranked 25th in D-1. Overall, they have relinquished 75 total points. Their defense has 1 fumble and 2 interceptions over the course of the season. The Rebels defense has taken the field for 270 plays, which ranks them 91st in the nation. The Rebels are relinquishing 18.8 PPG, which has them ranked 42nd in Division 1.

Who will win tonight's Tigers/Rebels college football game against the spread?

Josh's Pick: Take the Rebels -2.5

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