Michigan Wolverines vs Nebraska Cornhuskers Prediction, 9/20/2025 College Football Picks, Best Bets & Odds

Game: Michigan Wolverines vs Nebraska Cornhuskers

Date: Saturday, September 20, 2025

Location: Memorial Stadium in Lincoln, NE

TV: CBS Paramount+

Odds/Point Spread: Cornhuskers (+2.5)

Total/Over-Under: 45

Memorial Stadium is the location where the Nebraska Cornhuskers (3-0) will take on the Michigan Wolverines (2-1) on Saturday, September 20, 2025. Michigan opens this game as 2.5-point favorites. The over/under is 45.

The Michigan Wolverines head into this matchup 2-1 this season. In their last contest, the Wolverines played the Central Michigan Chippewas and notched a win by a score of 63-3. The Michigan Wolverines ended up rushing 55 different times and totaled 381 yds, which is an average of 6.9 yds per carry. When all was said and done, they ran 80 plays which totaled 616 yds. Michigan surrendered 11 completions on 20 attempts for a total of 60 yards, and a completion rate of 55.0%. When it came to stopping the run, the Wolverines conceded 79 yds on 33 tries, which is 2.4 yds per run surrendered.

The Wolverines have earned 1,356 yards in total for the year. When it comes to getting in the endzone, Michigan has compiled 2 touchdowns via the pass and 12 rushing touchdowns. They have turned the ball over 2 different times. Michigan has 67 first downs offensively, and they have been flagged for 15 penalties for 142 yards. Offensively they hold an average of 242.7 yards on the ground ranking them 15th in Division 1. When it comes to scoring, the Michigan Wolverines are averaging 36.7 points per contest.

In terms of passing yardage, the Wolverines have conceded 547 yds which puts them in 50th in the nation. They are conceding 182.3 yards per outing through the air in addition to conceding a completion percentage of 62.6%. During this campaign, they have relinquished 271.3 yards per outing which puts them 33rd in the nation. They have yielded 3 touchdowns via the pass as well as 2 touchdowns on the ground. They are allowing an average of 2.6 yards per rushing attempt and 89.0 rushing yards per contest for the campaign. Overall, they have given up 267 running yards through 3 games. The Wolverines sit in 33rd in college football when it comes to their opponents scoring, conceding 14.7 PPG.

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The Cornhuskers head into this matchup 3-0 this year. The last time they took the field, the Cornhuskers took home the win by a final score of 59-7 when they faced the Houston Christian Huskies. Nebraska ran the football for 5.1 yards per tote, finishing with 192 yds on 38 attempts. The Cornhuskers finished the contest with a total of 554 yards while they ran 67 plays (8.3 yards per play). The Cornhuskers passing defense gave up a completion percentage of 61.1%, relinquishing 67 yards on 11 for 18 through the air. Nebraska relinquished 35 rush attempts for 93 yards (2.7 yds per rush).

The Nebraska Cornhuskers maintain an average of 545.0 yards per contest, which is good for 10th in Division 1. The Nebraska offense has accrued 143 yds of penalties on 13 violations, which ranks them 107th in D-1 in terms of helping out the other team. They maintain an average of 178.7 yards per game via the rush and have run for 536 yards overall. They have thrown 0 interceptions while letting opponents recover 1 fumble and they have been able to earn 84 1st downs. Regarding how much they score, the Cornhuskers rank 9th in D-1 averaging 49.0 PPG. For the season thus far, the Cornhuskers have compiled 1,099 passing yards along with holding an average of 366.3 passing yards per contest, ranking them 5th in Division 1.

Nebraska has surrendered a total of 408 rushing yards (136.0 yards per outing) as well as 3 touchdowns by way of the ground game on the season. They have given up 0 touchdowns through the air and 66.0 yards/outing, which has them sitting 1st in Division 1. This season, they have conceded 24 pts. They have earned 4 fumbles recovered and 1 pick on the campaign. The Cornhuskers defense has taken the field for 167 plays, which has them ranked 29th in D-1. The Cornhuskers are conceding 8.0 PPG, which has them sitting 7th in the country.

Who will win tonight's Wolverines/Cornhuskers college football game against the spread?

Tony's Pick: Take the Wolverines -2.5

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