Michigan Wolverines vs Oklahoma Sooners Prediction, 9/6/2025 College Football Picks, Best Bets & Odds

Game: Michigan Wolverines vs Oklahoma Sooners

Date: Saturday, September 6, 2025

Location: Memorial Stadium in Norman, OK

TV: ESPN/ESPN+

Odds/Point Spread: Sooners (-5.5)

Total/Over-Under: 46

The Oklahoma Sooners (1-0) are hosting the Michigan Wolverines (1-0) at Memorial Stadium on Saturday, September 6, 2025. Michigan opens as 5.5-point underdogs. The total is set at 46.

The Michigan Wolverines head into this game 1-0 this season. The last time they stepped onto the field, the Wolverines went up against the New Mexico Lobos and notched a win by a score of 34-17. The Michigan Wolverines ran the rock 32 times and totaled 201 yds, which is an average of 6.3 yards per attempt. On the day, they ran 63 plays which gave them 452 yds. Michigan allowed 32 pass completions on 48 tries for a total of 217 yds, and a completion rate of 66.7%. In the running game, the Wolverines conceded 50 yards on 28 attempts, which is 1.8 yds per run surrendered.

When it comes to scoring points, the Michigan Wolverines hold an average of 34.0 points per game. As a team they are averaging 201.0 yards in the run game giving them a rank of 44th in the country. The Wolverines have tallied 452 total yards this year. In terms of scoring touchdowns, Michigan has compiled 1 touchdown through the air and 3 touchdowns via the ground. Michigan has earned 20 first downs as a team, and they have been flagged for 8 infractions for 65 yards. They have given the ball to the opposition 1 time.

The Wolverines sit in 73rd in the country regarding team defense, conceding 17.0 PPG. They are allowing an average of 1.8 yards per rushing attempt and 50.0 yards on the ground per game so far this year. Overall, they have conceded 50 yards via the ground game in 1 outing. When it comes to yards via the pass, the Wolverines are allowing 217 yards which ranks them 82nd in D-1. They have yielded 217.0 yards per contest via the pass and conceding a completion percentage of 66.7%. During the season, they have relinquished 267.0 yards per contest putting them 51st in Division 1. They have allowed 2 touchdowns through the air.

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The Sooners head into this matchup 1-0 for this season. When they last played, the Sooners walked away with a victory by a final of 35-3 when they played the Illinois State Redbirds. Oklahoma relinquished 26 rushing attempts for 117 yds (4.5 yards per carry). The Sooners passing defense gave up a completion percentage of 50.0%, relinquishing 34 yds on 10 for 20 through the air. The Sooners finished the game with 495 yds while running 69 plays (7.2 yards per play). Oklahoma rushed for 3.2 yds per attempt, finishing with a total of 103 yards on 32 carries.

In terms of how much they score, the Sooners currently rank 48th in D-1 averaging 35.0 PPG. The Oklahoma Sooners have an average of 495.0 yards per contest, which ranks them 23rd in Division 1. The Oklahoma offense has compiled 35 yards of penalties on 6 infractions, which is good for 64th in Division 1 in terms of helping out the other team. They have been able to earn 23 first downs. During the season thus far, the Sooners have compiled 392 yards through the air, ranking them 6th in the nation. They average 103.0 yards per game.

Oklahoma has yielded a total of 117 rushing yards. They have surrendered 34.0 passing yards per outing, which puts them in 2nd in D-1. They haven't forced a turnover. The Sooners defense has participated in 46 plays, which is good for 7th in the country. The Sooners are relinquishing 3.0 PPG, which has them 14th in the country.

Who will win tonight's Wolverines/Sooners college football game against the spread?

Guy's Pick: Take the Wolverines +5.5

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