Michigan Wolverines vs USC Trojans Prediction, 10/11/2025 College Football Picks, Best Bets & Odds

Game: Michigan Wolverines vs USC Trojans

Date: Saturday, October 11, 2025

Location: Los Angeles Memorial Coliseum in Los Angeles, CA

TV: NBC

Odds/Point Spread: Trojans (-1.5)

Total/Over-Under: 56.5

The Michigan Wolverines (4-1) are hitting the road to Los Angeles Memorial Coliseum on Saturday, October 11, 2025 where they will go up against the USC Trojans (4-1). USC is 1.5-point favorites. The total comes in at 56.5.

The Michigan Wolverines step onto the field holding a record of 4-1 for this season. In their last contest, the Wolverines went up against the Wisconsin Badgers and notched a win by a score of 24-10. The Michigan Wolverines ran the rock 34 times and accumulated 175 yds, which had them averaging 5.1 yds per carry. Once the final whistle blew, they had 62 plays which converted into 445 yds. Michigan conceded 18 completions on 29 attempts for a total of 177 yds, and a completion percentage of 62.1%. Against the run, the Wolverines conceded 75 yards on 28 attempts, which is an average of 2.7 yards per rush surrendered.

The Wolverines have racked up 2,192 total yards for the season. In terms of getting the ball in the endzone, Michigan has totaled 3 touchdowns via the pass and 17 touchdowns via the ground. They have turned the football over 3 times. Michigan has tallied 102 1st downs, and they have been hurt by 20 penalties for 191 yds. As a unit they have an average of 237.8 yards via the ground game which is 13th in Division 1. Concerning putting points on the board, the Michigan Wolverines hold an average of 32.8 points per outing.

When it comes to yards via the pass, the Wolverines have conceded 1,032 yards which puts them in 51st in D-1. They have yielded 206.4 yards per game via the pass and allowed a completion percentage of 65.1%. During this campaign, they have yielded 283.4 yards per outing which has them sitting 18th in Division 1. They have yielded 6 touchdowns through the air as well as 3 touchdowns on the ground. The opposition is running for an average of 2.4 yards per rush and 77.0 rushing yards per game for the year. During this campaign, they have conceded 385 yards via the running game in 5 contests. The Wolverines are ranked 24th in the country concerning team defense, giving up 16.2 points per game.

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The Trojans step onto the field holding a record of 4-1 for this season. The last time they took the gridiron, the Trojans took a defeat with a final score of 34-32 when they faced the Illinois Fighting Illini. The Trojans finished with 490 yards on 77 plays (6.4 yds per play). USC rushed the football for 3.7 yds per attempt, finishing the game with 126 yds on 34 attempts. USC relinquished 35 attempts on the ground for 171 yds (4.9 yards per rush). The Trojans passing defense gave up a completion rate of 77.8%, relinquishing 331 yds on 21 for 27 through the air.

The USC Trojans maintain an average of 565.0 yards per contest, ranking them 2nd in the country. The USC offense has totaled 392 yds of penalties on 41 infractions, which has them ranked 17th in the country in terms of helping out the opposition. They average 227.0 yards per game via the rush and have run for 1,135 yards for the season. They have thrown 1 interception while letting opponents recover 4 fumbles and they have earned 133 1st downs. Concerning their scoring prowess, the Trojans rank 3rd in college football scoring 48.4 points per game. Over the course of the season thus far, the Trojans have compiled 1,690 yards through the air in addition to an average of 338.0 throwing yards per contest, which is ranked 3rd in the country.

USC has given up a total of 542 yards rushing (108.4 yards/game) in addition to 3 touchdowns on the ground for the campaign. They have allowed the opposition 11 touchdowns via the pass as well as 251.0 yards/outing, which has them in 111th in Division 1. Over the course of the season, they have surrendered 115 points in total. Their defense has earned 3 fumbles recovered and 6 interceptions for the season. The Trojans defense has taken the field for 319 plays, which is good for 41st in Division 1. The Trojans are giving up 23.0 PPG, which has them ranked 64th in the nation.

Who will win tonight's Wolverines/Trojans college football game against the spread?

Guy's Pick: Take the Wolverines +1.5

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