Missouri Tigers vs Vanderbilt Commodores Prediction, 10/25/2025 College Football Picks, Best Bets & Odds

Game: Missouri Tigers vs Vanderbilt Commodores

Date: Saturday, October 25, 2025

Location: FirstBank Stadium in Nashville, TN

TV: ESPN

Odds/Point Spread: Commodores (-2.5)

Total/Over-Under: 52

FirstBank Stadium is the site where the Vanderbilt Commodores (6-1) will take on the Missouri Tigers (6-1) on Saturday, October 25, 2025. Vanderbilt opens this contest as 2.5-point favorites from oddsmakers. The betting total comes in at 52.

The Missouri Tigers come into this game with a record of 6-1 for this season. The last time they stepped onto the field, the Tigers took on the Auburn Tigers and walked away with a win by a score of 23-17. For the game, they had 84 plays which gave them 343 yds. The Missouri Tigers ended up rushing 44 different times and compiled 91 yds, which is an average of 2.1 yds per attempt. When it came to stopping the run, the Tigers conceded 150 yds on 41 tries, which is 3.7 yds per rush allowed. Missouri gave up 18 completions on 30 tries for a total of 207 yards, and a completion percentage of 60.0%.

In terms of putting the ball in the endzone, the Missouri Tigers have an average of 39.0 points per game. As a team they have an average of 244.9 yards on the ground which has them sitting 7th in the nation. The Tigers have racked up 3,406 total yards this year. When it comes to scoring, Missouri has earned 12 touchdowns via the pass and 22 touchdowns on the ground. Missouri has earned 185 first downs as a team, and they have committed 32 infractions for 329 yards. They have surrendered the football 8 different times.

When talking about yards via the pass, the Tigers have given up 1,114 yards which puts them in 16th in D-1. They have surrendered 159.1 yards per game through the air and giving up a completion percentage of 54.1%. For the season, they are allowing 243.0 yards/game which ranks them 5th in the country. They have relinquished 9 touchdowns via the pass and 4 touchdowns running the ball. The opposition is running for an average of 2.9 yards per rush on the ground and 83.9 rushing yards per game on the year. In total, they have given up 587 rushing yards through 7 contests. The Tigers rank 16th in D-1 in terms of their opponents scoring, giving up 16.7 points per game.

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The Commodores step onto the field holding a record of 6-1 for this season. When they last stepped on the gridiron, the Commodores got the victory with a final of 31-24 when they played the LSU Tigers. Vanderbilt ran for 5.3 yards per attempt, finishing the game with 239 yards on 45 carries. The Commodores finished the game with a total of 399 yards while running 67 plays (6.0 yds per play). The Commodores secondary gave up a completion percentage of 67.9%, surrendering 225 yds on 19 for 28 passing. Vanderbilt surrendered 21 attempts on the ground for 100 yards (4.8 yds per rush).

The Vanderbilt Commodores are averaging 457.7 yards per contest, which has them ranked 25th in D-1. The Vanderbilt offense has totaled 443 yds of penalties on 48 infractions, which ranks 39th in the country in terms of giving up free yards. They maintain an average of 213.0 rushing yards per game and have rushed for 1,491 yards for the year. They have thrown 4 interceptions while letting opponents recover 2 fumbles and they have been able to record 167 first downs. When it comes to their ability to score points, the Commodores sit 8th in D-1 holding an average of 41.4 points per contest. For the year thus far, the Commodores have a total of 1,713 yards via the pass along with holding an average of 244.7 throwing yards per outing, ranking them 57th in Division 1.

The Commodores are surrendering 20.0 PPG, which puts them 35th in the nation. Vanderbilt has allowed a total of 645 yards rushing (92.1 yards/game) as well as 3 touchdowns by way of the ground game for the year. They have allowed 13 touchdowns via the pass as well as 222.9 yards per contest, which has them ranked 72nd in D-1. The Commodores defense has taken the field for 418 plays, which is good for 25th in the nation. They have totaled 6 fumbles recovered and 4 picks on the year. Overall, they have allowed 140 points.

Who will win tonight's Tigers/Commodores college football game against the spread?

Guy's Pick: Take the Tigers +2.5

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