NC State Wolfpack vs Duke Blue Devils Prediction, 9/20/2025 College Football Picks, Best Bets & Odds

Game: NC State Wolfpack vs Duke Blue Devils

Date: Saturday, September 20, 2025

Location: Wallace Wade Stadium in Durham, NC

TV: ESPN2

Odds/Point Spread: Blue Devils (-3.5)

Total/Over-Under: 58

Wallace Wade Stadium is the site where the Duke Blue Devils (1-1) will try to defeat the NC State Wolfpack (3-0) on Saturday, September 20, 2025. Duke opens as 3.5-point favorites. The over/under has been set at 58.

The NC State Wolfpack head into this game 3-0 for this year. In their last matchup, the Wolfpack took the field against the Wake Forest Demon Deacons and took home the win by a score of 34-24. In the running game, the Wolfpack gave up 59 yards on 22 attempts, which is an average of 2.7 yards per run allowed. NC State relinquished 21 pass completions on 35 attempts for a total of 252 yards, and a completion percentage of 60.0%. In the game, they ran 76 plays which gave them a total of 406 yds. The NC State Wolfpack rushed the ball a total of 44 different times and totaled 205 yds, which is an average of 4.7 yards per tote.

The Wolfpack have tallied 1,245 yards in total for this campaign. When it comes to getting in the endzone, NC State has compiled 5 passing touchdowns and 6 touchdowns on the ground. They have turned the football over 1 time. NC State has accounted for 67 first downs, and they have committed 18 infractions for 172 yards. As a team they maintain an average of 175.3 yards on the ground giving them a rank of 64th in D-1. When talking about getting in the endzone, the NC State Wolfpack hold an average of 31.0 points per outing.

Regarding passing yards, the Wolfpack have conceded 892 yds which has them ranked 131st in the country. They have conceded 297.3 yards per contest via the pass as well as conceding a completion percentage of 66.6%. Over the course of this season, they are granting 412.7 yards/outing ranking them 107th in the country. They have surrendered 2 touchdowns through the air in addition to 6 touchdowns on the ground. The opposition is running for an average of 4.2 yards per rush and 115.3 yards on the ground per game for the season. Overall, they have allowed 346 running yards through 3 games. The Wolfpack rank 80th in D-1 when it comes to team defense, giving up 24.0 PPG.

Get all of our College Football Picks this Week

The Blue Devils come into this game with a record of 1-1 for this season. When they last played, the Blue Devils took a loss by a score of 34-27 against the Tulane Green Wave. The Blue Devils finished with 452 yards and they ran 75 plays (6.0 yards per play). Duke rushed for 5.8 yds per carry, finishing with a total of 139 yards on 24 carries. Duke allowed 38 attempts on the ground for 156 yards (4.1 yards per rush). The Blue Devils passing defense allowed a completion rate of 68.0%, relinquishing 270 yards on 17 for 25 passing.

The Duke Blue Devils hold an average of 479.3 yards per game, ranking them 26th in college football. The Duke offense has 169 yds of penalties on 18 infractions, which is 60th in the country in terms of helping out the other team. They average 126.7 yards via the ground game and have toted the ball for 380 yards for the year. They have given away 2 picks while allowing opponents to recover 5 fumbles and they have been able to tally 71 1st downs. When looking at their scoring prowess, the Blue Devils sit 67th in Division 1 holding an average of 30.3 points per outing. During the season thus far, the Blue Devils have a total of 1,058 passing yards as well as an average of 352.7 throwing yards per game, which has them ranked 10th in D-1.

The Blue Devils are giving up 32.0 PPG, which has them ranked 116th in Division 1. Duke has conceded a total of 442 yards rushing (147.3 yards per contest) and 9 touchdowns via the rush this year. They have allowed the opposition 3 touchdowns from the passing game and 226.0 yards per contest, ranking them 91st in D-1. The Blue Devils defense has been on the field for 198 plays, which is 79th in D-1. They have compiled 1 fumble recovered and 0 picks on the season. This year, they have conceded 96 points.

Who will win tonight's Wolfpack/Blue Devils college football game against the spread?

Guy's Pick: Take the Wolfpack +3.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here