Nebraska Cornhuskers vs Penn State Nittany Lions Prediction, 11/22/2025 College Football Picks, Best Bets & Odds

Game: Nebraska Cornhuskers vs Penn State Nittany Lions

Date: Saturday, November 22, 2025

Location: Beaver Stadium in University Park, PA

TV: NBC Peacock

Odds/Point Spread: Nittany Lions (-8.5)

Total/Over-Under: 44

Beaver Stadium is the site where the Penn State Nittany Lions (4-6) will attempt to defeat the Nebraska Cornhuskers (7-3) on Saturday, November 22, 2025. Penn State opens as 8.5-point favorites. The betting total comes in at 44.

The Nebraska Cornhuskers step onto the field holding a record of 7-3 for this season. In their last matchup, the Cornhuskers stepped onto the field against the UCLA Bruins and went home with a win by a final score of 28-21. Against the run, the Cornhuskers conceded 157 yards on 37 tries, which averages out to 4.2 yards per rush allowed. Nebraska surrendered 17 completions on 27 attempts for a total of 191 yards, and a completion percentage of 63.0%. For the game, they tallied 54 plays which converted into 361 yds. The Nebraska Cornhuskers ran the football 39 times and recorded 156 yards, earning them an average of 4.0 yds per carry.

The Cornhuskers have earned 3,856 yards in total for the year. When it comes to getting in the endzone, Nebraska has totaled 22 passing touchdowns and 16 rushing touchdowns. They have turned the ball over 9 times. Nebraska has compiled 216 1st downs as a unit, and they have been hurt by 44 infractions for 419 yds. As a team they maintain an average of 137.4 yards via the ground game ranking them 90th in the country. Concerning putting the ball in the endzone, the Nebraska Cornhuskers are sitting at 32.5 points per outing.

The Cornhuskers rank 25th in college football concerning team defense, allowing 19.9 points per game. Opposing teams are running for an average of 4.7 yards per running attempt and 161.1 rushing yards per game for the season. In total, they have conceded 1,611 rushing yards through 10 contests. In terms of passing yardage, the Cornhuskers are giving up 1,346 yards which ranks them 3rd in the nation. They are allowing 134.6 yards per contest through the air and allowed a completion percentage of 56.5%. In total, they are giving up 295.7 yards/contest which ranks them 15th in the nation. They have yielded 5 touchdowns through the air and 18 touchdowns pounding the rock.

Get all of our College Football Picks Against the Spread

The Nittany Lions step onto the field holding a record of 4-6 for this year. When they last stepped on the gridiron, the Nittany Lions walked away with a victory by a final of 28-10 when they played the Michigan State Spartans. Penn State ran the ball for 4.8 yds per carry, finishing with a total of 240 yds on 50 carries. The Nittany Lions finished the game with 367 yds while running 63 plays (5.8 yds per play). The Nittany Lions passing defense gave up a completion percentage of 61.3%, relinquishing 218 yds on 19 out of 31 passing. Penn State relinquished 31 run attempts for 108 yds (3.5 yards per rush).

The Penn State Nittany Lions average 338.8 yards per outing, which is good for 109th in D-1. The Penn State offense has racked up 331 penalty yds on 38 infractions, which has them ranked 131st in D-1 in terms of hurting your team. They average 159.9 yards per game via the rush and have run for 1,599 yards for the year. They have given away 7 picks while losing 3 fumbles and they have recorded 192 first downs. In terms of how much they score, the Nittany Lions are sitting 53rd in college football holding an average of 30.4 PPG. Over the course of the season to this point, the Nittany Lions have thrown for a total of 1,789 yards via the pass in addition to holding an average of 178.9 passing yards per game, which is ranked 114th in college football.

The Nittany Lions are surrendering 21.1 PPG, which has them sitting 35th in the nation. Penn State has conceded a total of 1,484 rushing yards (148.4 yards/game) in addition to 12 touchdowns via the rush so far this season. They have conceded 13 touchdowns through the air in addition to 167.7 yards per game, which has them in 12th in the nation. The Nittany Lions defense has been on the field for 625 plays, which is good for 28th in the country. They have 6 fumbles recovered and 6 picks on the season. Over the course of the season, they have surrendered 211 points in total.

Who will win tonight's Cornhuskers/Nittany Lions college football game against the spread?

Tony's Pick: Take the Nittany Lions -8.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get college football picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.