Northwestern Wildcats vs USC Trojans Prediction, 11/7/2025 College Football Picks, Best Bets & Odds

Game: Northwestern Wildcats vs USC Trojans

Date: Friday, November 7, 2025

Location: Los Angeles Memorial Coliseum in Los Angeles, CA

TV: FOX

Odds/Point Spread: Trojans (-14.0)

Total/Over-Under: 52.5

The Northwestern Wildcats (5-3) are en route to Los Angeles Memorial Coliseum on Friday, November 7, 2025 where they will compete against the USC Trojans (5-2). USC opens as 14.0-point favorites. The over/under has been set at 52.5.

The Northwestern Wildcats come into this game with a record of 5-3 for this year. In their last matchup, the Wildcats faced off with the Nebraska Cornhuskers and took a loss by a score of 28-21. Against the rush, the Wildcats gave up 155 yards on 39 tries, which averages out to 4.0 yards per rush allowed. Northwestern conceded 16 pass completions on 22 tries for 141 yds, and a completion rate of 72.7%. In all, they had 59 plays which gave them a total of 331 yards. The Northwestern Wildcats ended up rushing 30 times and had 172 yards, which had them averaging 5.7 yards per attempt.

Regarding getting in the endzone, the Northwestern Wildcats are averaging 22.5 points per game. Offensively they average 187.9 yards in the run game which has them sitting 29th in the country. The Wildcats have tallied 2,882 total yards for the season. When it comes to distribution of touchdowns, Northwestern has earned 10 passing touchdowns and 10 touchdowns via the ground. Northwestern has 170 1st downs offensively, and they have been flagged for 30 infractions for 228 yards. They have surrendered the football 13 times.

The Wildcats sit in 14th in college football in terms of their opponents scoring, conceding 16.8 PPG. They are allowing an average of 4.4 yards per running attempt and 139.0 rushing yards per game for the year. Over the course of this year, they have conceded 1,112 yards via the running game in 8 games. Regarding yards via the pass, the Wildcats are conceding 1,321 yds which puts them in 11th in D-1. They have conceded 165.1 yards per game via the pass and allowed a completion percentage of 60.0%. Over the course of this year, they are allowing 304.1 yards per contest which ranks them 19th in the nation. They have granted 6 touchdowns through the air as well as 9 touchdowns via the ground game.

Get all of our College Football Expert Picks

The Trojans step onto the field holding a record of 5-2 this season. In their last game, the Trojans got the win with a final of 21-17 when they faced the Nebraska Cornhuskers. The Trojans finished the contest with a total of 337 yds while they ran 61 plays (5.5 yards per play). USC rushed the ball for 5.3 yards per carry, totaling 202 yds on 38 carries. USC conceded 40 attempts on the ground for 188 yds (4.7 yards per rush). The Trojans passing defense allowed a completion rate of 68.2%, surrendering 98 yards on 15 for 22 through the air.

The USC Trojans average 505.9 yards/contest, which has them ranked 2nd in the country. The USC offense has racked up 477 penalty yards on 53 infractions, which ranks 68th in D-1 in terms of making mistakes. They hold an average of 203.6 yards per game via the ground game and have toted the ball for 1,629 yards in total. They have tossed 5 interceptions while losing 6 fumbles and they have recorded 200 1st downs. Regarding their scoring prowess, the Trojans currently rank 8th in college football maintaining an average of 39.8 points per contest. Over the course of the season thus far, the Trojans have thrown for 2,418 passing yards as well as holding an average of 302.3 passing yards per outing, which is ranked 10th in college football.

USC has given up a total of 1,145 rushing yards (143.1 yards/game) as well as 7 touchdowns by way of the ground game for the year. They have conceded 15 touchdowns through the air and 212.0 yards/contest, ranking them 58th in the nation. In total, they have given up 179 points in total. They have totaled 4 fumbles recovered and 9 picks on the year. The Trojans defense has participated in 508 plays, which is good for 19th in the country. The Trojans are allowing 22.4 PPG, ranking them 53rd in the nation.

Who will win tonight's Wildcats/Trojans college football game against the spread?

Guy's Pick: Take the Trojans -14.0

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get college football picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.