Ohio State Buckeyes vs Illinois Fighting Illini Prediction, 10/11/2025 College Football Picks, Best Bets & Odds

Game: Ohio State Buckeyes vs Illinois Fighting Illini

Date: Saturday, October 11, 2025

Location: Memorial Stadium in Champaign, IL

TV: FOX

Odds/Point Spread: Fighting Illini (+16.0)

Total/Over-Under: 50.5

The Illinois Fighting Illini (5-1) are hosting the Ohio State Buckeyes (5-0) at Memorial Stadium on Saturday, October 11, 2025. Ohio State opens this matchup as 16.0-point favorites. The total has been set at 50.5.

The Ohio State Buckeyes come into this matchup with a record of 5-0 for this season. In their last contest, the Buckeyes played the Minnesota Golden Gophers and earned the victory with a final of 42-3. Overall, they ran 58 plays for 474 yards. The Ohio State Buckeyes ended up rushing 30 different times and tallied 133 yds, which came out to an average of 4.4 yards per attempt. In the running game, the Buckeyes conceded 68 yds on 25 attempts, which averages out to 2.7 yds per rush surrendered. Ohio State relinquished 15 completions on 26 tries for a total of 94 yds, and a completion percentage of 57.7%.

The Buckeyes have earned 2,257 total yards over the course of this year. When it comes to getting in the endzone, Ohio State has earned 14 touchdowns via the pass and 10 rushing touchdowns. They have surrendered the football 4 times. Ohio State has amassed 114 first downs as a team, and they have been flagged for 20 infractions for 175 yards. As a team they're averaging 171.6 yards on the ground which ranks them 57th in Division 1. Concerning getting in the endzone, the Ohio State Buckeyes have an average of 37.4 PPG.

When talking about passing yards, the Buckeyes have allowed 622 yards which has them ranked 4th in the country. They have given up 124.4 yards per outing via the pass as well as conceding a completion percentage of 58.2%. During this campaign, they have yielded 215.8 yards per outing which has them sitting 3rd in the country. They have given up 2 touchdowns by air as well as 0 touchdown on the ground. The opposition is running for 2.9 yards per rush on the ground and 91.4 yards on the ground per contest on the campaign. Overall, they have allowed 457 running yards through 5 games. The Buckeyes are ranked 1st in Division 1 concerning the opposition scoring, giving up 5.0 PPG.

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The Fighting Illini step onto the field holding a record of 5-1 for this season. When they last stepped on the gridiron, the Fighting Illini got the victory with a final of 43-27 when they faced the Purdue Boilermakers. Illinois rushed for 2.9 yards per attempt, finishing the game with 117 yds on 41 attempts. The Fighting Illini finished the contest with a total of 507 yds and they ran 63 plays (8.0 yards per play). The Fighting Illini secondary allowed a completion rate of 60.0%, surrendering 302 yards on 30 out of 50 passing. Illinois surrendered 25 rush attempts for 151 yds (6.0 yards per rush).

The Illinois Fighting Illini maintain an average of 397.8 yards per outing, which is good for 65th in the nation. The Illinois offense has totaled 253 penalty yds on 30 infractions, which ranks them 80th in the nation in terms of making mistakes. They maintain an average of 130.7 run yards per game and have toted the ball for 784 yards for this year. They have thrown 1 picks while losing 2 fumbles and they have been able to tally 122 1st downs. In relation to their ability to score points, the Fighting Illini are sitting 27th in the country maintaining an average of 37.0 PPG. For the year to this point, the Fighting Illini have a total of 1,603 yards through the air in addition to an average of 267.2 passing yards per game, which ranks 38th in the nation.

Illinois has conceded a total of 811 yards on the ground (135.2 yards per game) and 8 touchdowns by way of the ground game on the season. They have surrendered 10 touchdowns through the air in addition to 252.3 yards per outing, which puts them in 113th in the country. In total, they have surrendered 144 points in total. Their defense has 8 fumbles recovered and 2 interceptions on the season. The Fighting Illini defense has been on the field for 400 plays, which ranks 124th in Division 1. The Fighting Illini are surrendering 24.0 PPG, ranking them 73rd in D-1.

Who will win tonight's Buckeyes/Fighting Illini college football game against the spread?

Guy's Pick: Take the Buckeyes -16.0

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