Oklahoma State Cowboys vs Oregon Ducks Prediction, 9/6/2025 College Football Picks, Best Bets & Odds

Game: Oklahoma State Cowboys vs Oregon Ducks

Date: Saturday, September 6, 2025

Location: Autzen Stadium in Eugene, OR

TV: CBS Paramount+

Odds/Point Spread: Ducks (-28.0)

Total/Over-Under: 57

The Oregon Ducks (1-0) are welcoming the Oklahoma State Cowboys (1-0) at Autzen Stadium on Saturday, September 6, 2025. Oregon opens as 28.0-point favorites. The over/under is set at 57.

The Oklahoma State Cowboys step onto the field holding a record of 1-0 for this year. In their last matchup, the Cowboys took the field against the Tennessee Martin Skyhawks and walked away with a win by a score of 27-7. When it came to stopping the run, the Cowboys gave up 116 yds on 38 attempts, which is 3.1 yards per run surrendered. Oklahoma State relinquished 10 pass completions on 17 tries for 109 yards, and a completion rate of 58.8%. Once the final whistle blew, they had 72 plays for 359 yds. The Oklahoma State Cowboys ran the rock 42 times and totaled 127 yards, which had them averaging 3.0 yards per tote.

When it comes to putting points on the board, the Oklahoma State Cowboys are sitting at 27.0 points per contest. As a team they maintain an average of 127.0 yards on the ground which ranks them 85th in the country. The Cowboys have racked up 359 total yards this season. When it comes to getting in the endzone, Oklahoma State has earned 1 touchdown through the air and 2 touchdowns via the ground. Oklahoma State has tallied 20 1st downs as a unit, and they have committed 5 infractions for 55 yds. They have yet to turn the ball over.

Concerning yards through the air, the Cowboys have given up 109 yards which puts them in 24th in Division 1. They have relinquished 109.0 yards per contest through the air and allowed a completion percentage of 58.8%. In total, they are allowing 225.0 yards/outing putting them 33rd in college football. They have granted 1 touchdown by air. The opposition is running for 3.1 yards per rush and 116.0 rushing yards per game for the season. Over the course of this year, they have allowed 116 rushing yards through 1 game. The Cowboys are ranked 25th in the nation when it comes to the opposition scoring, conceding 7.0 PPG.

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The Ducks come into this matchup with a record of 1-0 for this season. For their last game, the Ducks went home victorious with a score of 59-13 when they faced the Montana State Bobcats. Oregon ran the ball for 6.5 yards per tote, finishing with a total of 253 yards on 39 attempts. The Ducks finished the contest with a total of 506 yds and they ran 64 plays (7.9 yards per play). The Ducks passing defense allowed a completion percentage of 74.2%, surrendering 198 yds on 23 for 31 through the air. Oregon conceded 27 run attempts for 46 yds (1.7 yards per rush).

In relation to their ability to score points, the Ducks currently rank 9th in Division 1 with 59.0 PPG. The Oregon Ducks maintain an average of 506.0 yards per outing, ranking them 20th in the country. The Oregon offense has compiled 29 penalty yards on 3 violations, which ranks 115th in the nation in terms of making mistakes. They have earned 29 first downs. During this campaign so far, the Ducks have compiled 253 yards through the air, which has them ranked 43rd in the nation. They maintain an average of 253.0 run yards per game.

Oregon has conceded a total of 46 yards on the ground. They have allowed 198.0 passing yards per game, ranking them 78th in the country. They have yet to force a turnover. The Ducks defense has participated in 58 plays, which is good for 38th in the nation. The Ducks are giving up 13.0 points per contest, which puts them 55th in the nation.

Who will win tonight's Cowboys/Ducks college football game against the spread?

Josh's Pick: Take the Cowboys +28.0

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