Penn State Nittany Lions vs Michigan State Spartans Prediction, 11/15/2025 College Football Picks, Best Bets & Odds

Game: Penn State Nittany Lions vs Michigan State Spartans

Date: Saturday, November 15, 2025

Location: Spartan Stadium in East Lansing, MI

TV: FOX

Odds/Point Spread: Spartans (+6.5)

Total/Over-Under: 50

Spartan Stadium is the location where the Michigan State Spartans (3-6) will take on the Penn State Nittany Lions (3-5) on Saturday, November 15, 2025. Michigan State opens this game as 6.5-point underdogs from oddsmakers. The betting total is set at 50.

The Penn State Nittany Lions head into this matchup 3-5 for this season. In their last matchup, the Nittany Lions took the field against the Indiana Hoosiers and ended up losing by a score of 27-24. When all was said and done, they had 64 plays for 336 yds. The Penn State Nittany Lions ended up rushing 33 different times and accumulated 117 yards, earning them an average of 3.5 yards per carry. In the running game, the Nittany Lions gave up 108 yards on 31 tries, which is an average of 3.5 yds per run allowed. Penn State relinquished 19 completions on 31 tries for a total of 218 yds, and a completion rate of 61.3%.

In terms of scoring points, the Penn State Nittany Lions hold an average of 31.5 points per outing. As a unit they are averaging 155.3 yards on the ground ranking this team at 69th in the country. The Nittany Lions have tallied 2,685 total yards over the course of this season. In terms of scoring touchdowns, Penn State has totaled 9 touchdowns via the pass and 19 touchdowns via the ground. Penn State has 156 1st downs as a team, and they have been flagged for 29 infractions for 249 yards. They have turned the football over 8 different times.

Concerning passing yards, the Nittany Lions have conceded 1,331 yds which puts them in 10th in the country. They have conceded 166.4 yards per game via the pass in addition to giving up a completion percentage of 64.8%. For the season, they are giving up 325.8 yards per outing ranking them 35th in the country. They have given up 12 touchdowns through the air and 9 touchdowns on the ground. They are allowing 4.2 yards per attempt on the ground and 159.4 rushing yards per game on the year. Overall, they have given up 1,275 rushing yards through 8 contests. The Nittany Lions rank 40th in D-1 regarding team defense, allowing 21.8 PPG.

Get all of our College Football Picks

The Spartans head into this game 3-6 for this season. When they last stepped on the field, the Spartans took a loss by a final score of 23-20 when they faced the Minnesota Golden Gophers. Michigan State rushed the ball for 3.8 yds per attempt, finishing the contest with 156 yds on 41 carries. The Spartans ended up finishing with 467 yards while running 69 plays (6.8 yds per play). The Spartans passing defense gave up a completion percentage of 66.7%, surrendering 197 yds on 26 out of 39 passing. Michigan State allowed 23 rushing attempts for 104 yards (4.5 yards per rush).

In relation to their ability to score points, the Spartans are sitting 82nd in Division 1 holding an average of 25.6 PPG. The Michigan State Spartans are averaging 347.7 yards/game, which has them sitting 100th in the country. The Michigan State offense has 464 yds of penalties on 54 violations, which ranks 67th in Division 1 in terms of giving up free yards. They have tossed 4 picks while conceding 5 fumbles and they have been able to obtain 171 1st downs. During this campaign thus far, the Spartans currently have a total of 1,997 yards via the pass together with holding an average of 221.9 passing yards per game, which has them ranked 79th in the nation. They average 125.8 rushing yards per game and have rushed for 1,132 yards overall.

Michigan State has surrendered a total of 1,299 yards on the ground (144.3 yards/game) and 18 touchdowns via the rush on the season. They have allowed 17 touchdowns through the air in addition to 227.0 yards per outing, which puts them in 78th in the country. This season, they have allowed 283 points. Their defense has totaled 3 fumbles recovered and 3 picks on the season. The Spartans defense has taken the field for 560 plays, which ranks them 60th in the country. The Spartans are giving up 31.4 points per game, which has them ranked 116th in Division 1.

Who will win tonight's Nittany Lions/Spartans college football game against the spread?

Josh's Pick: Take the Nittany Lions -6.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get college football picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.