Pittsburgh Panthers vs Syracuse Orange Prediction, 10/18/2025 College Football Picks, Best Bets & Odds

Game: Pittsburgh Panthers vs Syracuse Orange

Date: Saturday, October 18, 2025

Location: JMA Wireless Dome in Syracuse, NY

TV: ACC Network

Odds/Point Spread: Orange (+11.0)

Total/Over-Under: 55.5

The Syracuse Orange (3-3) will take on the Pittsburgh Panthers (4-2) at JMA Wireless Dome on Saturday, October 18, 2025. Pittsburgh opens this matchup as 11.0-point favorites. The over/under is set at 55.5.

The Pittsburgh Panthers come into this game with a record of 4-2 for this year. In their last matchup, the Panthers played the Florida State Seminoles and notched a win by a score of 34-31. The Pittsburgh Panthers ran the rock 42 times and accounted for 155 yds, earning them an average of 3.7 yds per attempt. Overall, they tallied 71 plays which converted into 476 yards. Pittsburgh allowed 16 pass completions on 23 attempts for 245 yds, and a completion percentage of 69.6%. In the running game, the Panthers gave up 170 yards on 40 tries, which averages out to 4.3 yds per rush surrendered.

The Panthers have tallied 2,591 total yards this year. When it comes to getting in the endzone, Pittsburgh has amassed 18 touchdowns via the pass and 9 rushing touchdowns. They have given the ball to the opposition 10 different times. Pittsburgh has accrued 126 1st downs as an offense, and they have been called for 42 infractions for 379 yards. As a team they're maintaining an average of 122.5 yards in the run game which ranks them 105th in college football. Concerning putting the ball in the endzone, the Pittsburgh Panthers have an average of 39.8 PPG.

When talking about yards via the pass, the Panthers are conceding 1,381 yards which has them ranked 79th in the country. They are allowing 230.2 yards per outing through the air as well as allowing a completion percentage of 64.0%. Over the course of this season, they have yielded 312.3 yards/game which puts them 30th in the country. They have surrendered 10 touchdowns via the pass as well as 6 touchdowns via the ground game. They are allowing teams to run for an average of 2.2 yards per run and 82.2 rushing yards per game for the year. Over the course of this season, they have conceded 493 yards via the ground game in 6 games. The Panthers are sitting in 54th in D-1 when it comes to their opponents scoring, giving up 21.5 points per game.

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The Orange head into this matchup 3-3 for this season. In their last game, the Orange went home defeated by a final of 31-18 when they faced the SMU Mustangs. The Orange finished the game with 389 yards while running 78 plays (5.0 yds per play). Syracuse ran the ball for 3.3 yards per attempt, finishing with 110 yards on 33 carries. Syracuse conceded 28 rushing attempts for 76 yds (2.7 yards per rush). The Orange passing defense allowed a completion percentage of 83.3%, relinquishing 294 yards on 30 out of 36 through the air.

When it comes to putting points on the board, the Orange sit 69th in the nation maintaining an average of 29.0 PPG. The Syracuse Orange have an average of 432.3 yards per outing, which ranks them 37th in Division 1. The Syracuse offense has racked up 290 yds of penalties on 31 infractions, which ranks them 103rd in college football in terms of giving up free yards. They have given away 7 interceptions while letting opponents recover 5 fumbles and they have recorded 141 1st downs. For the season thus far, the Orange have thrown for 1,924 yards via the pass together with holding an average of 320.7 passing yards per contest, which ranks 6th in college football. They maintain an average of 111.7 yards per game on the ground and have rushed for 670 yards overall.

The Orange are allowing 29.8 points per game, ranking them 114th in Division 1. Syracuse has surrendered a total of 946 rushing yards (157.7 yards per outing) in addition to 7 touchdowns by way of the ground game for the campaign. They have surrendered 15 touchdowns from the passing game as well as 291.2 yards per outing, which has them sitting 131st in D-1. The Orange defense has participated in 441 plays, which is good for 121st in D-1. They have compiled 3 fumbles and 4 picks for the year. Overall, they have allowed 179 pts.

Who will win tonight's Panthers/Orange college football game against the spread?

Guy's Pick: Take the Panthers -11.0

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