Rutgers Scarlet Knights vs Ohio State Buckeyes Prediction, 11/22/2025 College Football Picks, Best Bets & Odds

Game: Rutgers Scarlet Knights vs Ohio State Buckeyes

Date: Saturday, November 22, 2025

Location: Ohio Stadium in Columbus, OH

TV: FOX

Odds/Point Spread: Buckeyes (-31.5)

Total/Over-Under: 55.5

The Ohio State Buckeyes (10-0) will try to beat the Rutgers Scarlet Knights (5-5) at Ohio Stadium on Saturday, November 22, 2025. Rutgers opens this contest as 31.5-point underdogs from Vegas oddsmakers. The total is 55.5.

The Rutgers Scarlet Knights come into this matchup with a record of 5-5 this season. The last time they stepped onto the field, the Scarlet Knights played against the Maryland Terrapins and went home with a win by a final score of 35-20. In the running game, the Scarlet Knights conceded 305 yds on 29 attempts, which is an average of 10.5 yards per rush surrendered. Rutgers allowed 15 pass completions on 28 attempts for 98 yards, and a completion rate of 53.6%. In the game, they had 69 plays which converted into 485 yards. The Rutgers Scarlet Knights rushed the ball a total of 49 different times and accounted for 256 yards, which came out to an average of 5.2 yards per tote.

The Scarlet Knights have attained 4,205 yards in total for the season. When it comes to getting the ball in the endzone, Rutgers has earned 19 touchdowns via the pass and 16 touchdowns via the ground. They have given the ball to the opposition 9 times. Rutgers has accounted for 240 1st downs as an offense, and they have committed 39 penalties for 312 yards. As a unit they hold an average of 143.1 yards in the run game ranking this team at 86th in D-1. When it comes to getting in the endzone, the Rutgers Scarlet Knights are sitting at 29.9 PPG.

The Scarlet Knights are ranked 107th in college football in terms of team defense, allowing 30.0 points per game. They are allowing teams to run for an average of 6.6 yards per tote and 196.5 rushing yards per contest on the campaign. For the season, they have allowed 1,965 rushing yards through 10 games. In terms of yards through the air, the Scarlet Knights have conceded 2,290 yards which ranks them 82nd in the nation. They have given up 229.0 yards per game through the air as well as giving up a completion percentage of 64.3%. Over the course of this year, they have surrendered 425.5 yards per game which puts them 122nd in college football. They have yielded 20 touchdowns via the pass and 18 touchdowns running the ball.

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The Buckeyes come into this game with a record of 10-0 for this season. When they last stepped on the gridiron, the Buckeyes took home the win by a final score of 48-10 against the UCLA Bruins. Ohio State ran the football for 6.7 yds per carry, finishing with a total of 222 yards on 33 attempts. The Buckeyes finished the contest with a total of 440 yards and they ran 67 plays (6.6 yards per play). The Buckeyes pass defense gave up a completion percentage of 59.1%, relinquishing 94 yards on 13 out of 22 passing. Ohio State gave up 22 run attempts for 92 yds (4.2 yards per carry).

The Ohio State Buckeyes have an average of 441.3 yards/game, which has them ranked 25th in D-1. The Ohio State offense has 377 yds of penalties on 43 violations, which has them ranked 124th in D-1 in terms of helping out the opposition. They maintain an average of 161.8 yards per game on the ground and have rushed for 1,618 yards for the year. They have tossed 4 interceptions while surrendering 2 fumbles and they have been able to obtain 234 first downs. When it comes to how much they score, the Buckeyes are sitting 11th in D-1 by scoring 37.5 PPG. For the season thus far, the Buckeyes currently have a total of 2,795 yards through the air as well as an average of 279.5 passing yards per game, ranking them 19th in Division 1.

Ohio State has allowed a total of 825 yards via the ground game (82.5 yards per game) as well as 3 touchdowns via the rush on the campaign. They have allowed 5 touchdowns through the air and 131.2 yards/game, which has them ranked 2nd in college football. Over the course of the season, they have allowed 75 total points. They have compiled 5 fumbles recovered and 6 picks over the course of the season. The Buckeyes defense has taken part in 550 plays, which has them ranked 1st in the nation. The Buckeyes are allowing 7.5 points per game, which puts them 1st in the country.

Who will win tonight's Scarlet Knights/Buckeyes college football game against the spread?

Guy's Pick: Take the Scarlet Knights +31.5

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