Southern Miss Golden Eagles vs South Alabama Jaguars Prediction, 11/22/2025 College Football Picks, Best Bets & Odds

Game: Southern Miss Golden Eagles vs South Alabama Jaguars

Date: Saturday, November 22, 2025

Location: Hancock Whitney Stadium in Mobile, AL

TV: ESPN+

Odds/Point Spread: Jaguars (+2.0)

Total/Over-Under: 54.5

The Southern Miss Golden Eagles (7-3) are headed to Hancock Whitney Stadium on Saturday, November 22, 2025 where they will attempt to beat the South Alabama Jaguars (3-7). South Alabama opens this game as 2.0-point dogs from Vegas oddsmakers. The total is 54.5.

The Southern Miss Golden Eagles head into this matchup 7-3 for this season. In their last matchup, the Golden Eagles played the Texas State Bobcats and went home with a loss by a final score of 41-14. When all was said and done, they had 74 plays for 391 yds. The Southern Miss Golden Eagles ran the ball a total of 30 different times and compiled 124 yds, which had them averaging 4.1 yds per carry. Against the run, the Golden Eagles conceded 119 yards on 34 tries, which averages out to 3.5 yards per run allowed. Southern Miss gave up 38 pass completions on 53 tries for 337 yds, and a completion percentage of 71.7%.

The Golden Eagles have attained 4,100 total yards for the year. In terms of getting in the endzone, Southern Miss has compiled 21 passing touchdowns and 15 touchdowns on the ground. They have surrendered the football 12 times. Southern Miss has 217 first downs as a team, and they have been called for 72 penalties for 600 yards. As a team they hold an average of 150.8 yards in the run game which has them sitting 77th in Division 1. Regarding scoring, the Southern Miss Golden Eagles are averaging 30.5 points per contest.

When it comes to yards through the air, the Golden Eagles have given up 2,231 yards which ranks them 72nd in the country. They have yielded 223.1 yards per outing via the pass in addition to giving up a completion percentage of 61.6%. For the season, they are granting 395.4 yards per game putting them 93rd in D-1. They have given up 10 touchdowns via the pass as well as 21 touchdowns on the ground. Opposing teams are running for an average of 4.1 yards per tote and 172.3 yards on the ground per game on the year. Over the course of this season, they have given up 1,723 rushing yards through 10 games. The Golden Eagles rank 79th in the country regarding the opposition scoring, allowing 25.9 PPG.

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The Jaguars step onto the field holding a record of 3-7 for this year. When they last stepped on the gridiron, the Jaguars got the win with a final of 26-14 against the UL Monroe Warhawks. The Jaguars finished the game with a total of 362 yds and they ran 76 plays (4.8 yds per play). South Alabama ran for 3.8 yds per carry, finishing the game with 200 yards on 53 attempts. South Alabama conceded 46 running attempts for 161 yds (3.5 yds per rush). The Jaguars secondary allowed a completion percentage of 82.4%, surrendering 232 yds on 14 for 17 through the air.

The South Alabama Jaguars have an average of 375.9 yards per game, which ranks them 76th in the nation. The South Alabama offense has racked up 567 yds of penalties on 69 infractions, which is good for 39th in the nation in terms of helping out the opposition. They maintain an average of 192.8 yards per game via the rush and have toted the ball for 1,928 yards for this season. They have thrown 5 interceptions while surrendering 6 fumbles and they have recorded 200 first downs. Concerning how much they score, the Jaguars are sitting 84th in the nation by scoring 25.0 points per contest. During the season thus far, the Jaguars currently have a total of 1,831 yards through the air in addition to an average of 183.1 passing yards per contest, which ranks 110th in D-1.

South Alabama has yielded a total of 1,815 rushing yards (181.5 yards per contest) and 20 touchdowns via the rush on the season. They have allowed the opposition 14 touchdowns from the passing game in addition to 177.9 yards per game, which has them in 19th in the nation. In total, they have surrendered 281 total points. Their defense has totaled 7 fumbles and 5 picks this season. The Jaguars defense has been on the field for 640 plays, ranking them 33rd in D-1. The Jaguars are allowing 28.1 PPG, which has them sitting 92nd in the country.

Who will win tonight's Golden Eagles/Jaguars college football game against the spread?

Guy's Pick: Take the Golden Eagles -2.0

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