Syracuse Orange vs Clemson Tigers Prediction, 9/20/2025 College Football Picks, Best Bets & Odds

Game: Syracuse Orange vs Clemson Tigers

Date: Saturday, September 20, 2025

Location: Memorial Stadium in Clemson, SC

TV: ESPN

Odds/Point Spread: Tigers (-17.0)

Total/Over-Under: 55.5

Memorial Stadium is the location where the Clemson Tigers (1-2) will attempt to beat the Syracuse Orange (2-1) on Saturday, September 20, 2025. Syracuse opens as 17.0-point underdogs. The total has been set at 55.5.

The Syracuse Orange come into this matchup with a record of 2-1 this year. The last time they stepped onto the field, the Orange played against the Colgate Raiders and walked away with a win by a score of 66-24. In the running game, the Orange conceded 107 yds on 29 attempts, which is 3.7 yards per rush allowed. Syracuse allowed 30 completions on 54 tries for a total of 301 yards, and a completion rate of 55.6%. In all, they ran 72 plays which gave them 620 yds. The Syracuse Orange ended up running the ball 35 times and accounted for 173 yds, which is an average of 4.9 yds per carry.

The Orange have earned 1,458 total yards this season. When it comes to getting in the endzone, Syracuse has earned 9 touchdowns via the pass and 7 touchdowns via the ground. They have turned the football over 6 times. Syracuse has amassed 80 first downs as a team, and they have been called for 14 infractions for 123 yds. As a unit they're holding an average of 107.0 yards via the ground game which ranks them 123rd in the country. Concerning putting the ball in the endzone, the Syracuse Orange have an average of 39.7 PPG.

The Orange are ranked 109th in the nation concerning the opposition scoring, allowing 29.7 points per game. The opposition is running for 4.8 yards per rush and 165.0 yards on the ground per game for the campaign. During this campaign, they have conceded 495 yards on the ground through 3 games. Regarding passing yardage, the Orange have conceded 822 yds which ranks them 120th in D-1. They have yielded 274.0 yards per game through the air and allowed a completion percentage of 56.4%. For the year, they have surrendered 439.0 yards per game which puts them 122nd in Division 1. They have allowed 6 touchdowns by air and 4 touchdowns via the ground game.

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The Tigers step onto the field holding a record of 1-2 this year. The last time they took the field, the Tigers took a defeat with a final score of 24-21 when they faced the Georgia Tech Yellow Jackets. Clemson ran for 5.0 yds per attempt, finishing with 174 yds on 35 attempts. The Tigers finished the contest with 381 yards while running 61 plays (6.2 yards per play). The Tigers pass defense allowed a completion rate of 71.4%, surrendering 211 yards on 20 out of 28 passing. Clemson conceded 42 run attempts for 147 yds (3.5 yards per carry).

In relation to this team's ability to score points, the Tigers currently rank 112th in the country with 19.3 points per contest. The Clemson Tigers have an average of 319.3 yards per outing, which ranks them 111th in Division 1. The Clemson offense has 112 penalty yds on 11 infractions, which has them ranked 121st in Division 1 in terms of making mistakes. They have tossed 3 interceptions while losing 2 fumbles and they have been able to earn 47 first downs. For the season to this point, the Tigers currently sit at 633 yards through the air as well as holding an average of 211.0 passing yards per game, giving them a rank of 81st in Division 1. They hold an average of 108.3 yards via the ground game and have rushed for 325 yards in total.

The Tigers are allowing 19.0 points per game, which has them ranked 54th in Division 1. Clemson has surrendered a total of 333 yards rushing (111.0 yards per game) in addition to 3 touchdowns via the rush on the season. They have allowed 2 touchdowns via the pass and 227.3 yards per contest, which puts them in 94th in the country. The Tigers defense has taken part in 203 plays, which ranks them 91st in the nation. Their defense has earned 2 fumbles recovered and 3 interceptions so far this year. In total, they have given up 57 points in total.

Who will win tonight's Orange/Tigers college football game against the spread?

Parlays Pundit's Pick: Take the Tigers -17.0

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