UNLV Rebels vs Wyoming Cowboys Prediction, 10/4/2025 College Football Picks, Best Bets & Odds

Game: UNLV Rebels vs Wyoming Cowboys

Date: Saturday, October 4, 2025

Location: War Memorial Stadium in Laramie, WY

TV: CBSSN

Odds/Point Spread: Cowboys (+5.0)

Total/Over-Under: 53

The Wyoming Cowboys (2-2) will compete against the UNLV Rebels (4-0) at War Memorial Stadium on Saturday, October 4, 2025. Wyoming opens this matchup as 5.0-point underdogs. The total is 53.

The UNLV Rebels head into this game 4-0 for this year. In their last contest, the Rebels took on the Miami RedHawks and notched a win by a score of 41-38. The UNLV Rebels ended up running the ball 43 times and amassed 220 yards, which had them averaging 5.1 yards per carry. At the end of the game, they ran 86 plays which gave them 513 yards. UNLV relinquished 15 completions on 31 attempts for a total of 265 yds, and a completion percentage of 48.4%. When it came to the battle of the line of scrimmage, the Rebels gave up 131 yds on 22 attempts, which is an average of 6.0 yds per run allowed.

The Rebels have earned 1,802 yards in total for the season. When it comes to scoring touchdowns, UNLV has earned 8 passing touchdowns and 9 rushing touchdowns. They have surrendered the ball 4 times. UNLV has accumulated 95 1st downs, and they have committed 35 infractions for 347 yards. As a team they average 206.3 yards rushing giving them a rank of 31st in college football. When talking about putting the ball in the endzone, the UNLV Rebels are averaging 36.8 points per contest.

The Rebels are sitting in 103rd in college football when it comes to team defense, allowing 28.3 PPG. The opposition is running for an average of 5.4 yards per rush and 152.3 yards on the ground per game so far this season. Over the course of this season, they have conceded 609 yards via the ground game in 4 contests. When it comes to yards through the air, the Rebels have conceded 1,102 yards which has them ranked 100th in D-1. They have given up 275.5 yards per outing via the pass and giving up a completion percentage of 58.8%. Overall, they have allowed 427.8 yards per contest which ranks them 120th in college football. They have allowed 7 touchdowns by air and 5 touchdowns on the ground.

Get all of our College Football Picks this Week

The Cowboys head into this matchup 2-2 this season. When they last stepped on the gridiron, the Cowboys took a loss by a final score of 37-20 against the Colorado Buffaloes. The Cowboys finished the contest with a total of 347 yards while they ran 67 plays (5.2 yards per play). Wyoming ran the ball for 4.0 yards per carry, finishing with a total of 165 yds on 41 carries. Wyoming conceded 31 attempts on the ground for 193 yds (6.2 yds per rush). The Cowboys pass defense allowed a completion percentage of 64.3%, relinquishing 304 yds on 18 out of 28 passing.

Concerning how much they score, the Cowboys are sitting 126th in the country by scoring 16.8 PPG. The Wyoming Cowboys are averaging 345.3 yards/contest, which ranks them 102nd in college football. The Wyoming offense has compiled 280 yards of penalties on 32 violations, which ranks 41st in D-1 in terms of making mistakes. They have given away 2 interceptions while conceding 2 fumbles and they have been able to earn 79 1st downs. For the season so far, the Cowboys have thrown for 740 yards through the air as well as an average of 185.0 passing yards per outing, which has them ranked 104th in Division 1. They have an average of 160.3 yards per game via the rush and have toted the ball for 641 yards for the season.

The Cowboys are surrendering 18.8 points per game, which has them 37th in D-1. Wyoming has yielded a total of 652 yards rushing (163.0 yards per outing) and 5 touchdowns via the rush on the year. They have given up 5 touchdowns through the air in addition to 196.0 yards per outing, which puts them in 54th in college football. The Cowboys defense has participated in 269 plays, which ranks 43rd in Division 1. Their defense has tallied 2 fumbles and 3 picks so far this year. Overall, they have conceded 75 points.

Who will win tonight's Rebels/Cowboys college football game against the spread?

Guy's Pick: Take the Rebels -5.0

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here