USC Trojans vs Illinois Fighting Illini Prediction, 9/27/2025 College Football Picks, Best Bets & Odds

Game: USC Trojans vs Illinois Fighting Illini

Date: Saturday, September 27, 2025

Location: Memorial Stadium in Champaign, IL

TV: FOX

Odds/Point Spread: Fighting Illini (+7.0)

Total/Over-Under: 59

The USC Trojans (4-0) are traveling to Memorial Stadium on Saturday, September 27, 2025 where they will compete against the Illinois Fighting Illini (3-1). Illinois opens this matchup as 7.0-point dogs. The total is set at 59.

The USC Trojans step onto the field holding a record of 4-0 for this year. In their last game, the Trojans took the field against the Michigan State Spartans and went home with a win by a final score of 45-31. When it came to stopping the run, the Trojans conceded 112 yards on 32 tries, which averages out to 3.5 yards per run allowed. USC surrendered 13 completions on 23 attempts for a total of 225 yds, and a completion rate of 56.5%. On the day, they tallied 66 plays which gave them 523 yds. The USC Trojans rushed the ball a total of 40 different times and had 289 yards, earning them an average of 7.2 yards per tote.

The Trojans currently have 2,335 yards in total this season. When it comes to scoring touchdowns, USC has amassed 10 touchdowns via the pass and 15 touchdowns via the ground. They have given the ball to the opposition 3 times. USC has 104 first downs, and they have been flagged for 33 infractions for 323 yds. Offensively they hold an average of 252.3 yards via the ground game which is 12th in the country. When it comes to scoring, the USC Trojans are sitting at 52.5 points per game.

The Trojans rank 55th in D-1 concerning the opposition scoring, conceding 20.3 PPG. They are giving up 3.0 yards per rush and 92.8 rushing yards per game this season. Over the course of this year, they have allowed 371 running yards through 4 games. Regarding passing yardage, the Trojans are conceding 924 yds which ranks them 98th in the country. They are conceding 231.0 yards per outing through the air in addition to giving up a completion percentage of 60.1%. For the year, they have given up 323.8 yards per outing which has them sitting 52nd in the nation. They have yielded 8 touchdowns via the pass as well as 2 touchdowns on the ground.

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The Fighting Illini come into this matchup with a record of 3-1 for this year. When they last stepped on the field, the Fighting Illini took a defeat with a final score of 63-10 against the Indiana Hoosiers. The Fighting Illini finished with a total of 161 yds on 45 plays (3.6 yards per play). Illinois rushed the ball for 0.1 yards per tote, finishing the game with 2 yards on 20 carries. Illinois allowed 49 attempts on the ground for 312 yards (6.4 yards per rush). The Fighting Illini pass defense gave up a completion percentage of 91.3%, relinquishing 267 yards on 21 out of 23 passing.

The Illinois Fighting Illini are averaging 344.5 yards/contest, which has them sitting 103rd in D-1. The Illinois offense has compiled 180 yards of penalties on 21 infractions, which is 82nd in college football in terms of making mistakes. They hold an average of 124.0 yards per game on the ground and have run for 496 yards for the year. They have tossed 1 picks while losing 0 fumbles and they have been able to earn 75 1st downs. Concerning their scoring prowess, the Fighting Illini are ranking 43rd in Division 1 with an average of 36.3 PPG. For the season so far, the Fighting Illini have a total of 882 passing yards not to mention an average of 220.5 throwing yards per outing, which has them sitting 75th in D-1.

The Fighting Illini are relinquishing 21.3 points per game, which has them 62nd in college football. Illinois has surrendered a total of 534 yards on the ground (133.5 yards per game) in addition to 3 touchdowns via the rush this season. They have surrendered 7 touchdowns through the air and 212.0 yards/game, which has them sitting 69th in the nation. The Fighting Illini defense has participated in 248 plays, which is good for 69th in D-1. Their defense has compiled 5 fumbles recovered and 1 interception so far this year. In total, they have relinquished 85 pts.

Who will win tonight's Trojans/Fighting Illini college football game against the spread?

Tony's Pick: Take the Trojans -7.0

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