UTSA Roadrunners vs Colorado State Rams Prediction, 9/20/2025 College Football Picks, Best Bets & Odds
Game: UTSA Roadrunners vs Colorado State Rams
Date: Saturday, September 20, 2025
Location: Canvas Stadium in Fort Collins, CO
TV: FS1
Odds/Point Spread: Rams (+4.5)
Total/Over-Under: 59.5
The Colorado State Rams (1-1) will try to beat the UTSA Roadrunners (1-2) at Canvas Stadium on Saturday, September 20, 2025. Colorado State opens this contest as 4.5-point dogs. The over/under is set at 59.5.
The UTSA Roadrunners head into this game 1-2 for this season. In their last game, the Roadrunners went up against the Incarnate Word Cardinals and went home with a win by a final score of 48-20. The UTSA Roadrunners ran the ball a total of 35 times and compiled 204 yards, which had them averaging 5.8 yards per tote. In all, they had 70 plays which converted into 442 yards. UTSA conceded 31 pass completions on 45 tries for a total of 324 yds, and a completion percentage of 68.9%. When it came to stopping the run, the Roadrunners conceded 33 yards on 27 attempts, which averages out to 1.2 yds per rush allowed.

The Roadrunners have earned 1,279 total yards for the year. In terms of distribution of touchdowns, UTSA has compiled 7 touchdowns through the air and 7 rushing touchdowns. They haven't turned the ball over yet. UTSA has accumulated 64 1st downs as an offense, and they have committed 16 infractions for 154 yards. As a team they maintain an average of 217.3 yards in the run game which is 28th in the country. When talking about putting the ball in the endzone, the UTSA Roadrunners hold an average of 36.0 PPG.
The Roadrunners are sitting in 121st in the country when it comes to their opponents scoring, conceding 35.0 points per game. Opposing teams are running for an average of 3.2 yards per rushing attempt and 103.0 yards on the ground per game for the campaign. In total, they have allowed 309 yards via the ground game in 3 games. When talking about passing yardage, the Roadrunners have conceded 901 yards which puts them in 132nd in the country. They are allowing 300.3 yards per game via the pass in addition to giving up a completion percentage of 65.3%. During the season, they have yielded 403.3 yards per game ranking them 101st in D-1. They have surrendered 8 touchdowns through the air in addition to 5 touchdowns running the ball.
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The Rams step onto the field holding a record of 1-1 this year. When they last stepped on the field, the Rams walked away with a victory by a final of 21-17 against the Northern Colorado Bears. Colorado State relinquished 34 running attempts for 63 yds (1.9 yds per carry). The Rams passing defense gave up a completion percentage of 60.7%, surrendering 160 yards on 17 out of 28 passing. The Rams ended up finishing with 371 yards while they ran 72 plays (5.2 yards per play). Colorado State ran for 5.0 yds per carry, finishing with a total of 230 yards on 46 attempts.
When looking at their ability to score points, the Rams are ranked 105th in Division 1 averaging 21.0 points per outing. The Colorado State Rams have an average of 318.0 yards per game, which has them ranked 113th in the nation. The Colorado State offense has racked up 114 yds of penalties on 15 infractions, which has them ranked 90th in college football in terms of giving up free yards. They have thrown 2 picks while conceding 4 fumbles and they have recorded 44 1st downs. During this campaign to this point, the Rams have racked up 321 yards through the air along with holding an average of 160.5 throwing yards per contest, giving them a rank of 115th in Division 1. They are averaging 157.5 yards per game on the ground and have rushed for 315 yards for the year.
Colorado State has yielded a total of 346 yards on the ground (173.0 yards per outing) and 6 touchdowns by way of the ground game for the year. They have conceded 1 touchdown through the air in addition to 193.0 yards/outing, which has them sitting 55th in Division 1. This year, they have relinquished 55 points. Their defense has totaled 2 fumbles and 1 interception this season. The Rams defense has been on the field for 137 plays, which has them ranked 16th in Division 1. The Rams are surrendering 27.5 points per contest, which has them ranked 100th in the nation.
Who will win tonight's Roadrunners/Rams college football game against the spread?
Tony's Pick: Take the Rams +4.5
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Additional Resources:
Colorado State Rams - Twitter
UTSA Roadrunners - Twitter