Charlotte 49ers vs Ole Miss Rebels Prediction, 9/12/2026 College Football Picks, Best Bets & Odds

Game: Charlotte 49ers vs Ole Miss Rebels

Date: Saturday, September 12, 2026

Location: Vaught-Hemingway Stadium in Oxford, MS

TV: ESPN+

Odds/Point Spread: Rebels (-48.0)

Total/Over-Under: 61.5

Vaught-Hemingway Stadium is the location where the Ole Miss Rebels (1-0) will take on the Charlotte 49ers (0-1) on Saturday, September 12, 2026. Ole Miss opens this matchup as 48-point favorites. The betting total comes in at 61.5.

The Charlotte 49ers come into this game with a record of 0-1 for this year. In their last contest, the 49ers went up against the The Citadel Bulldogs and ended up losing by a score of 43-41. In the game, they ran 74 plays which gave them a total of 538 yds. The Charlotte 49ers ended up rushing 33 times and tallied 216 yds, which had them averaging 6.5 yds per carry. When it came to stopping the run, the 49ers conceded 268 yds on 50 tries, which calculates to 5.4 yds per run allowed. Charlotte allowed 9 pass completions on 13 tries for a total of 132 yards, and a completion percentage of 69.2%.

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In terms of scoring points, the Charlotte 49ers have an average of 41.0 points per outing. As a team they're holding an average of 216.0 yards on the ground which ranks them 46th in the nation. The 49ers have earned 538 total yards for the year. In terms of scoring, Charlotte has compiled 3 passing touchdowns and 3 touchdowns via the ground. Charlotte has amassed 21 first downs, and they have been called for 6 penalties for 35 yards. They have turned the football over 2 times.

When talking about passing yards, the 49ers have given up 132 yds which has them ranked 42nd in the nation. They are giving up 132.0 yards per contest through the air as well as allowing a completion percentage of 69.2%. In total, they are giving up 400.0 yards per game ranking them 101st in the nation. They have yielded no touchdowns by air in addition to 6 touchdowns pounding the rock. They are giving up 5.4 yards per attempt on the ground and 268.0 yards on the ground per game on the season. In total, they have given up 268 rushing yards through 1 outing. The 49ers rank 122nd in Division 1 regarding team defense, conceding 43.0 points per game.

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The Rebels step onto the field holding a record of 1-0 for this year. The last time they took the gridiron, the Rebels got the victory with a final of 41-38 when they played the Louisville Cardinals. Ole Miss allowed 39 run attempts for 162 yards (4.2 yds per carry). The Rebels secondary allowed a completion percentage of 62.1%, surrendering 307 yds on 18 out of 29 passing. The Rebels finished the contest with 488 yards while they ran 78 plays (6.3 yds per play). Ole Miss rushed the ball for 3.7 yards per attempt, finishing with 152 yds on 41 attempts.

In relation to the points being put on the board, the Rebels rank 46th in the country scoring 41.0 points per outing. The Ole Miss Rebels hold an average of 488.0 yards per outing, which has them sitting 46th in Division 1. The Ole Miss offense has accrued 60 penalty yards on 6 violations, which ranks 73rd in D-1 in terms of making mistakes. They have given away 1 pick while letting opponents recover 1 fumble and they have earned 24 1st downs. During the season thus far, the Rebels have earned 336 yards via the pass. They average 152.0 yards per game on the ground.

The Rebels are conceding 38.0 PPG, which has them sitting 113th in Division 1. Ole Miss has conceded a total of 162 yards on the ground and 2 touchdowns by way of the ground game on the campaign. They have allowed 2 touchdowns via the pass in addition to 307.0 yards/outing, which has them in 118th in college football. The Rebels defense has taken part in 68 plays, which ranks them 86th in the country. Their defense has no fumbles and no interceptions this season.

Who will win tonight's 49ers/Rebels college football game against the spread?

Guy's Pick: Take the Rebels -48.0

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