Stanford Cardinal vs Notre Dame Fighting Irish Prediction, 10/10/2026 College Football Picks, Best Bets & Odds

Game: Stanford Cardinal vs Notre Dame Fighting Irish

Date: Saturday, October 10, 2026

Location: Notre Dame Stadium in Notre Dame, IN

TV: NBC

Odds/Point Spread: Fighting Irish (-38.0)

Total/Over-Under: 53.5

The Stanford Cardinal (2-3) are hitting the road to Notre Dame Stadium on Saturday, October 10, 2026 where they will try to beat the Notre Dame Fighting Irish (5-0). Notre Dame opens this matchup as 38-point favorites. The over/under is 53.5.

The Stanford Cardinal head into this matchup 2-3 for this year. In their last matchup, the Cardinal went up against the Wake Forest Demon Deacons and walked away from this one with a loss by a score of 57-3. In the running game, the Cardinal conceded 197 yards on 37 tries, which averages out to 5.3 yards per run allowed. Stanford surrendered 22 pass completions on 30 tries for a total of 322 yds, and a completion rate of 73.3%. At the end of the game, they had 67 plays which converted into 197 yards. The Stanford Cardinal ended up rushing 34 different times and had 49 yards, which earned them an average of 1.4 yards per tote.

The Cardinal have tallied 1,683 total yards for the season. In terms of getting the ball in the endzone, Stanford has compiled 5 touchdowns via the pass and 4 rushing touchdowns. They have surrendered the football 2 times. Stanford has 88 first downs as a unit, and they have been flagged for 37 infractions for 303 yds. As a team they're averaging 88.8 yards on the ground ranking them 135th in D-1. When it comes to scoring, the Stanford Cardinal are sitting at 17.4 points per game.

When it comes to passing yards, the Cardinal have given up 1,499 yds which has them sitting in 137th in college football. They are allowing 299.8 yards per outing via the pass and giving up a completion percentage of 68.5%. For the year, they have surrendered 458.8 yards/outing which ranks them 134th in college football. They have yielded 12 touchdowns by air and 14 touchdowns pounding the rock. The opposition is running for an average of 4.7 yards per rush and 159.0 rushing yards per game for the season. Overall, they have given up 795 rushing yards through 5 outings. The Cardinal are ranked 133rd in the country in terms of team defense, conceding 38.2 PPG.

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The Fighting Irish come into this matchup with a record of 5-0 for this season. The last time they took the field, the Fighting Irish walked away with a victory by a final of 37-26 against the North Carolina Tar Heels. The Fighting Irish finished with 475 yds while they ran 74 plays (6.4 yds per play). Notre Dame rushed the ball for 5.4 yards per carry, totaling 241 yds on 45 carries. Notre Dame allowed 23 rushing attempts for 77 yards (3.3 yds per rush). The Fighting Irish passing defense conceded a completion percentage of 60.7%, surrendering 208 yards on 17 for 28 passing.

The Notre Dame Fighting Irish have an average of 428.4 yards per game, ranking them 46th in college football. The Notre Dame offense has racked up 138 yards of penalties on 14 violations, ranking them 138th in D-1 in terms of hurting your team. They hold an average of 161.6 rushing yards per game and have toted the ball for 808 yards for this year. They have given away 1 interception while allowing opponents to recover no fumbles and they have earned 109 first downs. Regarding the points being put on the board, the Fighting Irish are 15th in college football maintaining an average of 41.2 points per contest. During this campaign to this point, the Fighting Irish have thrown for 1,334 yards through the air as well as an average of 266.8 passing yards per outing, which has them ranked 38th in Division 1.

Notre Dame has given up a total of 292 yards on the ground (58.4 yards per game) and 1 touchdown on the ground this year. They have given up 5 touchdowns from the passing game and 158.0 yards per game, which puts them in 14th in the country. This season, they have relinquished 59 points. Their defense has compiled 6 fumbles recovered and 5 picks so far this year. The Fighting Irish defense has taken the field for 271 plays, which has them ranked 21st in the nation. The Fighting Irish are conceding 11.8 points per contest, which has them ranked 7th in college football.

Who will win tonight's Cardinal/Fighting Irish college football game against the spread?

Tony's Pick: Take the Fighting Irish -38.0

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