Arizona Wildcats vs Houston Cougars Prediction, 10/18/2025 College Football Picks, Best Bets & Odds
Game: Arizona Wildcats vs Houston Cougars
Date: Saturday, October 18, 2025
Location: TDECU Stadium in Houston, TX
TV: FS1
Odds/Point Spread: Cougars (-2.5)
Total/Over-Under: 47.5
TDECU Stadium is the location where the Houston Cougars (5-1) will take on the Arizona Wildcats (4-2) on Saturday, October 18, 2025. Arizona opens this matchup as 2.5-point underdogs. The total comes in at 47.5.
The Arizona Wildcats head into this game 4-2 for this season. The last time they took the field, the Wildcats faced the BYU Cougars and took a loss by a final of 33-27. On the ground, the Wildcats gave up 258 yds on 51 attempts, which averages out to 5.1 yards per rush surrendered. Arizona surrendered 12 completions on 29 attempts for 172 yds, and a completion rate of 41.4%. On the day, they tallied 79 plays for 383 yards. The Arizona Wildcats ran the rock 34 times and had 164 yds, earning them an average of 4.8 yds per carry.

Concerning scoring, the Arizona Wildcats have an average of 32.2 points per outing. As a team they're averaging 147.2 yards on the ground which ranks them 79th in college football. The Wildcats have earned 2,533 total yards for this campaign. With reference to getting in the endzone, Arizona has totaled 15 touchdowns through the air and 7 touchdowns via the ground. Arizona has earned 139 1st downs, and they have committed 34 penalties for 278 yards. They have surrendered the football 8 different times.
When talking about passing yards, the Wildcats have allowed 908 yds which puts them in 10th in the nation. They have conceded 151.3 yards per game through the air and conceding a completion percentage of 49.7%. For the season, they have allowed 275.7 yards per game putting them at 15th in D-1. They have surrendered 1 touchdown by air as well as 10 touchdowns pounding the rock. The opposition is running for an average of 3.5 yards per running attempt and 124.3 rushing yards per contest on the season. In total, they have conceded 746 yards via the running game in 6 outings. The Wildcats are sitting in 28th in D-1 regarding team defense, conceding 18.5 PPG.
Get all of our College Football Expert Picks
The Cougars come into this game with a record of 5-1 for this season. The last time they took the gridiron, the Cougars walked away with a victory by a final of 39-17 against the Oklahoma State Cowboys. Houston relinquished 31 rushing attempts for 45 yds (1.5 yards per carry). The Cougars secondary allowed a completion percentage of 45.0%, relinquishing 180 yards on 9 out of 20 passing. The Cougars finished with a total of 485 yds while they ran 79 plays (6.1 yds per play). Houston ran the ball for 3.7 yds per carry, finishing with a total of 166 yds on 45 carries.
The Houston Cougars are averaging 378.3 yards per outing, ranking them 75th in college football. The Houston offense has totaled 307 yards of penalties on 35 violations, which is good for 81st in the nation in terms of making mistakes. They maintain an average of 159.2 rushing yards per game and have rushed for 955 yards for this year. They have thrown 3 interceptions while surrendering 1 fumbles and they have been able to record 109 1st downs. Concerning the points being put on the board, the Cougars are sitting 66th in D-1 holding an average of 29.2 points per game. During the season thus far, the Cougars currently sit at 1,315 passing yards along with an average of 219.2 passing yards per contest, which is ranked 77th in the nation.
The Cougars are surrendering 17.5 PPG, which has them ranked 23rd in D-1. Houston has given up a total of 753 rushing yards (125.5 yards per contest) as well as 7 touchdowns by way of the ground game this season. They have conceded 5 touchdowns from the passing game and 181.0 yards/game, which has them ranked 29th in the nation. The Cougars defense has taken part in 405 plays, which has them ranked 77th in college football. Their defense has tallied 2 fumbles recovered and 6 interceptions on the year. In total, they have relinquished 105 points in total.
Who will win tonight's Wildcats/Cougars college football game against the spread?
Guy's Pick: Take the Cougars -2.5
Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here
Get all of this Weeks Free College Football Picks
Get all of this Weeks Expert College Football Picks
Additional Resources:
Houston Cougars - Twitter
Arizona Wildcats - Twitter