Western Kentucky Hilltoppers vs Louisiana Tech Bulldogs Prediction, 10/21/2025 College Football Picks, Best Bets & Odds
Game: Western Kentucky Hilltoppers vs Louisiana Tech Bulldogs
Date: Tuesday, October 21, 2025
Location: Joe Aillet Stadium in Ruston, LA
TV: CBSSN
Odds/Point Spread: Bulldogs (-3.5)
Total/Over-Under: 50
Joe Aillet Stadium is the location where the Louisiana Tech Bulldogs (4-2) will attempt to beat the Western Kentucky Hilltoppers (5-2) on Tuesday, October 21, 2025. Louisiana Tech opens this contest as 3.5-point favorites. The total has been set at 50.
The Western Kentucky Hilltoppers head into this matchup 5-2 for this season. In their last matchup, the Hilltoppers faced the FIU Panthers and went home with a loss by a final score of 25-6. Overall, they ran 64 plays which gave them 341 yds. The Western Kentucky Hilltoppers ran the football 23 times and amassed 116 yards, which is an average of 5.0 yds per carry. In the running game, the Hilltoppers gave up 249 yards on 39 attempts, which calculates to 6.4 yards per run allowed. Western Kentucky relinquished 20 pass completions on 31 tries for a total of 204 yds, and a completion rate of 64.5%.

The Hilltoppers have earned 2,918 total yards for the year. When it comes to distribution of touchdowns, Western Kentucky has amassed 13 passing touchdowns and 10 touchdowns via the ground. They have surrendered the football 10 different times. Western Kentucky has 151 1st downs offensively, and they have been called for 48 penalties for 521 yds. Offensively they are averaging 122.3 yards rushing ranking this team at 110th in college football. Concerning scoring points, the Western Kentucky Hilltoppers have an average of 29.7 PPG.
The Hilltoppers are ranked 59th in Division 1 concerning their opponents scoring, allowing 23.1 points per game. Opposing teams are running for an average of 5.6 yards per rush on the ground and 203.4 rushing yards per game this season. In total, they have given up 1,424 rushing yards through 7 outings. Concerning yards through the air, the Hilltoppers have given up 1,398 yards which puts them in 46th in the nation. They have surrendered 199.7 yards per outing via the pass and giving up a completion percentage of 55.2%. During this campaign, they are giving up 403.1 yards/outing which puts them 104th in the country. They have yielded 5 touchdowns via the pass in addition to 10 touchdowns via the ground game.
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The Bulldogs head into this matchup 4-2 this year. The last time they took the field, the Bulldogs took a loss by a score of 35-7 when they faced the Kennesaw State Owls. Louisiana Tech rushed for 3.4 yards per tote, totaling 136 yds on 40 attempts. The Bulldogs ended up finishing with 305 yards on 75 plays (4.1 yds per play). The Bulldogs pass defense conceded a completion percentage of 75.0%, relinquishing 290 yds on 27 for 36 through the air. Louisiana Tech relinquished 27 rush attempts for 110 yds (4.1 yards per rush).
The Louisiana Tech Bulldogs hold an average of 311.0 yards/game, which has them sitting 124th in the country. The Louisiana Tech offense has racked up 463 yards of penalties on 47 infractions, which ranks 50th in college football in terms of helping out the opposition. They are averaging 146.5 yards per game via the ground game and have rushed for 879 yards in total. They have thrown 4 interceptions while conceding 3 fumbles and they have been able to earn 105 1st downs. When it comes to this team's ability to score points, the Bulldogs currently sit 90th in D-1 scoring 24.5 PPG. For the season to this point, the Bulldogs currently sit at 987 passing yards along with holding an average of 164.5 passing yards per outing, ranking them 120th in Division 1.
Louisiana Tech has surrendered a total of 638 yards on the ground (106.3 yards/game) in addition to 2 touchdowns via the rush for the year. They have surrendered 10 touchdowns through the air as well as 249.0 yards per game, which has them sitting 110th in Division 1. This year, they have conceded 103 points. Their defense has tallied 2 fumbles and 11 interceptions this year. The Bulldogs defense has taken the field for 418 plays, which has them ranked 26th in college football. The Bulldogs are conceding 17.2 PPG, which has them 20th in the country.
Who will win tonight's Hilltoppers/Bulldogs college football game against the spread?
Guy's Pick: Take the Bulldogs -3.5
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Additional Resources:
Louisiana Tech Bulldogs - Twitter
Western Kentucky Hilltoppers - Twitter