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NCAA Football Predictions: Week 2 Opening Line Report, Best Bets and Picks

by Cameron McQuade - 9/5/2022

NCAA football predictions opening line report week 2 Anthony Richardson Florida Gators

Week 1 of college football has officially happened. This Thursday the NFL kicks off, and what a time of year it is -- some may say it’s better than Christmas! Last week we had some surprising and great games; Old Dominion stunned Virginia Tech, 20-17, Ohio State vs Notre Dame brought every celebrity out to the sidelines, including Lebron James and Joe Burrow, for a 21-10 Buckeyes win. To review our picks last week, we went 1/3 on “Cams College 3 Best Bet,” but we plan to do better this week. Penn State went as expected, being a close match but beating Purdue by more than 3.5 points, winning 35-31. Liberty vs Southern Miss was somewhat correct, but 50% right doesn’t win you a dollar in betting. Liberty won 29-27 in OT, but failed to cover the -3.5 spread. If you bet the money line on this one, you’d be a winner. Our biggest miss of the week was San Diego State. Being a -6.0 favorite, Arizona came to play and ruin the housewarming party in the Aztecs new stadium, winning easily, 38-20! Looking at our “Other Picks” section, we went 2/3, finishing us at 3/6, 50% hits on Week 1.

We look to improve that going into Week 2 here, so let’s begin.

Doc’s Sports offers college football picks for every game on our college football predictions page.

Cam’s College 3 Best Bets

Florida (-4.5) vs Kentucky (+4.5) Saturday 7 p.m. EST

This is a battle of two schools that started their year on the right foot. Both 1-0 teams come into Saturday hoping to stay undefeated, but one team will have to take the loss. Since 2000, Florida has won 20 games vs Kentucky out of 22 matchups. This is a trend that I believe will stick come Saturday. Even though last season UK upset the Gators, 20-13, I believe Florida will win this year’s SEC matchup. The Gators have scored a total of 785 points vs the Wildcats’ 365 total points since 2000, while averaging 35.68 points per match. Kentucky averages only 16.59 points per game vs Florida.

Pick: Florida -4.5, but best bet would be to play the ML -200.

Louisville (+6.5) vs Central Florida (-6.5) Friday 7:30 p.m. EST

Louisville took a difficult road loss last week to Syracuse, 31-7. The Cardinals do come into this season with plenty of hype, with a much-improved offense. I think Week 1 was an outlier game, getting the jitters out. They come into Friday’s matchup playing UCF only twice since 2013, splitting those games. Most recently, the two met last season in September, and Louisville won 42-35. Prior to last year’s meeting, UCF won in 2013, 39-35. With Louisville being an underdog in this matchup, I love taking the points here.

Pick: Louisville +6.5

Arkansas (-8) vs South Carolina (+8) Saturday 12 p.m. EST

These teams have not met since 2017. The South Carolina Gamecocks have won the past 3 meetings vs the Razorbacks. However, since 2000, Arkansas does have the winning record of 8 wins out of 15 total matchups (8-7). Plus, this time around, Arkansas is favored for a reason. They are much better team all around, from offensive efficiency, defensive ability to coaching credibility. Look for QB KJ Jefferson to have another dominant game vs South Carolina’s defense. Last week vs Cincinnati, the junior QB threw for 4 touchdowns. I believe Arkansas will win this matchup by 9, covering the 8-point spread.

Pick: Arkansas -8. Predicting the final score to be 30-21.

Other Picks I like:

Kansas to cover (+13) vs West Virginia

Baylor to cover (+3.5) vs BYU

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