Jacksonville Jaguars vs Cincinnati Bengals Prediction, 9/14/2025 NFL Picks, Best Bets & Odds Week 2

Game: Jacksonville Jaguars vs Cincinnati Bengals

Date: Sunday, September 14, 2025

Location: Paycor Stadium in Cincinnati, OH

TV: CBS

Odds-Point Spread: Bengals (-3.5)

Total-Over-Under: 49.5

The Jacksonville Jaguars (1-0) are on their way to Paycor Stadium on Sunday where they will compete against the Cincinnati Bengals (1-0). Jacksonville opens this game as 3.5-point underdogs from oddsmakers. The betting total is set at 49.5.

The Jacksonville Jaguars head into this matchup 1-0 for this campaign. In their last game, the Jaguars played the Carolina Panthers and took home the win by a score of 26-10. Trevor Lawrence connected on 19-31 with 178 yards passing and 1 touchdown. He had a quarterback rating of 74.4 and finished the game with 1 interception. Travis Etienne was the rushing leader for the Jaguars with 16 totes for 143 yards (8.9 yards per carry). Travis Hunter had an average of 5.5 yds per catch by recording 33 yds on 6 catches. The Jacksonville Jaguars ended up running the ball 32 times and had 200 yards, which earned them an average of 6.3 yards per attempt. In all, they ran 63 plays which gave them 378 yds. Jacksonville surrendered 18 completions on 35 tries for a total of 142 yds, and a completion percentage of 51.4%. In the running game, the Jaguars gave up 113 yards on 25 attempts, which averages out to 4.5 yds per run surrendered.

If you analyze scoring touchdowns, the Jaguars average 26.0 points per game. As a team, they're holding an average of 200.0 rush yds which has them ranking 3rd in the league. The Jaguars have earned 378 yds on the campaign. Jacksonville has compiled 9 1st downs as a team, and they have committed 11 infractions for 93 yards. They have turned the ball over 1 time. If you're looking at getting the ball in the endzone, Jacksonville has accumulated 1 passing touchdown and 1 rushing touchdown.

If you're looking at pass yards, the Jaguars have surrendered 142 yds, putting them 6th in pro football. They are yielding a completion% of 51.4%. They have surrendered 1 touchdown by way of the pass. On the whole, they are yielding 255.0 total yards per game, ranking them 8th in pro football. They are allowing an average of 4.5 yds per running attempt and 113.0 rushing yds per outing over the course of this year. The Jaguars currently sit 4th in pro football in terms of their defensive abilities, conceding 10.0 PPG.

Get all of our NFL Expert Picks

The Bengals step onto the field with a record of 1-0 over the course of this year. The last time they stepped on the gridiron, the Bengals walked away with a victory by a final of 17-16 when they played the Cleveland Browns. Joe Burrow (1 TD) walked away from the game with 113 yds on 14-23 through the air while his QB rating was 87.8. He kept the ball away from the defense with no picks and his average yds per pass attempt was 4.9 yds. Chase Brown carried the ball 21 times for 43 yards, ending the contest with 2.0 yds per attempt for Cincinnati. Noah Fant was one of the featured targets for the Bengals, grabbing 4 passes for 26 yds (6.5 yards per catch). Cincinnati rushed the football for 2.0 yards per carry, totaling 46 yards on 23 carries. The Bengals finished the contest with a total of 141 yards on 46 plays (3.1 yds per play). The Bengals pass defense allowed a completion percentage of 68.9%, surrendering 278 yds on 31 for 45 passing. Cincinnati gave up 24 running attempts for 49 yds (2.0 yards per carry).

When talking about how much they score, the Bengals rank 20th in professional football, with 17.0 points per game. This year, the Bengals have compiled 95 passing yds ranking this team at 31st in professional football. They have run for 46 yds. The Cincinnati Bengals average 141.0 yards per contest, which is 31st in professional football. The Cincinnati offense has yielded 33 yards on 7 penalties, which ranks 17th in professional football if you're looking at helping out the opposition.

They have granted 1 touchdown via the pass plus 278.0 pass yds per outing, which ranks 28th in professional football. Cincinnati has granted a total of 49 rush yards. The D has accumulated 2 takeaways. The Bengals defense has been on the field for 71 plays from scrimmage, which ranks 28th in professional football. The Bengals are conceding 16.0 points per contest, ranking them 11th in football.

Who will win tonight's Jaguars-Bengals NFL game against the spread?

Guy's Pick: Take the Bengals -3.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here