Arizona Cardinals vs Indianapolis Colts Prediction, 10/12/2025 NFL Picks, Best Bets & Odds Week 6

Game: Arizona Cardinals vs Indianapolis Colts

Date: Sunday, October 12, 2025

Location: Lucas Oil Stadium in Indianapolis, IN

TV: FOX

Odds-Point Spread: Colts (-6.5)

Total-Over-Under: 47.5

The Arizona Cardinals (2-3) are headed to Lucas Oil Stadium on Sunday where they will go up against the Indianapolis Colts (4-1). Indianapolis opens this matchup as 6.5-point favorites from oddsmakers. The total comes in at 47.5.

The Arizona Cardinals step onto the field holding a record of 2-3 over the course of the season. The last time they stepped on the football field, the Cardinals stepped onto the field against the Tennessee Titans and walked away from this one with a loss by a score of 22-21. Michael Carter was the rushing leader for the Cardinals with 18 totes for 51 yards (2.8 yds per attempt). Michael Carter left with an average of 4.4 yds per catch by totaling 22 yards on 5 receptions. Kyler Murray went 23-31 with 220 yds through the air. He had a QB rating of 93.5 and ended the contest with no picks. On the ground, the Cardinals gave up 78 yds on 24 attempts, which averages out to 3.3 yds per run allowed. Arizona gave up 21 pass completions on 39 attempts for a total of 249 yards, and a completion rate of 53.8%. Overall, they had 61 plays which totaled 360 yds. The Arizona Cardinals ended up running the ball 29 different times and compiled 168 yards, which earned them an average of 5.8 yds per carry.

The Cardinals currently have 1,442 yds on the campaign. Arizona has recorded 50 first downs, and they have been hurt by 41 penalties for 273 total yards. If you're looking at putting points on the board, Arizona has produced 6 passing touchdowns and 4 ground TD's. They have surrendered the ball 6 different times (3 INTs and 3 lost fumbles). Offensively, they're holding an average of 118.2 rushing yards putting them 12th in pro football. When you look at notching touchdowns, the NFC West members are sitting at 20.6 points per contest.

Concerning yards through the air, the Cardinals have granted 1,271 yards, which is 29th in professional football. They have relinquished 254.2 total yards per contest through the air, and are giving up a completion% of 61.8%. On the whole, they have given up 462 yards via the ground game in 5 outings over the course of this year. They have conceded 5 touchdowns by way of the pass, and 3 touchdowns by way of the ground game. On the whole, they are conceding 346.6 total yards per outing, ranking them 21st in the NFL. The opposition is running for 3.9 yds per rush and 92.4 running yds per outing for the year. The Cardinals are 4th in the league if you analyze their opponents scoring, surrendering 19.2 points per contest.

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The Colts come into this matchup holding a record of 4-1 for the year. In their last contest, the Colts walked away with a victory by a final of 40-6 when they faced the Las Vegas Raiders. Daniel Jones (2 TDs) ended the game with 212 yards on 20-29 through the air while his quarterback rating was 113. He didn't throw any interceptions and his avg yards per attempt was 7.3 yards. Josh Downs was a featured target for the Colts, hauling in 6 passes for 54 yards (9.0 yds per catch). Jonathan Taylor carried the ball 17 times for 66 yards, finishing the contest with 3.9 yds per attempt for Indianapolis. The Colts finished the contest with 317 yards and they ran 57 plays (5.6 yds per play). Indianapolis ran the football for 3.8 yds per carry, finishing with 96 yards on 25 carries. Indianapolis allowed 25 rushing attempts for 106 yards (4.2 yards per rush). The Colts passing defense conceded a completion rate of 69.4%, relinquishing 190 yards on 25 out of 36 passing.

If you're looking at this team's ability to score points, the Colts currently rank 2nd in football, holding an average of 32.6 PPG. On the campaign, the Colts have a total of 1,265 yards through the air and are averaging 253.0 yards through the air per outing, ranking them 4th in the NFL. They hold an average of 128.2 running yds per outing, and have run for 641 total yards. The Indianapolis Colts hold an average of 381.2 total yards per outing, ranking them 4th in the NFL. The Indianapolis offense has yielded 301 yds by way of 39 violations, which is 12th in football with reference to helping out the opposition. They have a total of 2 INTs while allowing 1 fumble, and have tallied 63 first downs.

The Colts are allowing 17.8 PPG, putting them 3rd in pro football. They have conceded 8 touchdowns by way of the pass and 217.0 pass yards per game, putting them 19th in the league. Indianapolis has yielded a total of 490 rushing yds (98.0 yds per outing), and 2 touchdowns via the rush this season. The Colts defense has taken the field for 300 plays from scrimmage, which is 17th in football. The defense has earned 8 turnovers (2 forced fumbles and 6 interceptions) this season. In total, they have yielded 89 points.

Who will win tonight's Cardinals-Colts NFL game against the spread?

Josh's Pick: Take the Cardinals +6.5

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