Arizona Cardinals vs New Orleans Saints Prediction, 9/7/2025 NFL Picks, Best Bets & Odds Week 1

Game: Arizona Cardinals vs New Orleans Saints

Date: Sunday, September 7, 2025

Location: Caesars Superdome in New Orleans, LA

TV: CBS

Odds-Point Spread: Saints (+6.5)

Total-Over-Under: 43

Caesars Superdome is the place where the New Orleans Saints (5-12 last year) will try to defeat the Arizona Cardinals (8-9 last season) on Sunday. Arizona is 6.5-point favorites. The over-under is set at 43.

The Arizona Cardinals finished the year having a 8-9 mark. In their last game, the Cardinals took the field against the San Francisco 49ers and took home the win by a score of 47-24. Kyler Murray connected on 25-35 with 242 yds passing and 4 touchdowns. He had a QB rate of 128.5 and ended the contest without throwing an interception. Trey McBride held an average of 9.3 yds per reception by earning 65 yards on 7 receptions. Tony Jones was the rushing leader for the Cardinals with 4 totes for 55 yds (13.8 yards per carry). In all, they had 62 plays which converted into 393 yards. The Arizona Cardinals ran the football 27 different times and compiled 151 yds, earning them an average of 5.6 yds per attempt. When it came to stopping the run, the Cardinals gave up 138 yds on 28 attempts, which averages out to 4.9 yards per run allowed. Arizona relinquished 29 pass completions on 43 tries for 298 yds, and a completion percentage of 67.4%.

If you examine distribution of touchdowns, the NFC West representatives held an average of 23.5 points per contest. As a team, they held an average of 144.2 rush yards, which had them sitting 7th in the NFL. The Cardinals recorded 6,090 yds for the previous season. Arizona earned 191 1st downs as a team, and they committed 92 penalties for 806 yds. They gave the ball away 20 different times (11 interceptions and 9 fumbles lost). Arizona accrued 21 passing TD's and 18 touchdowns on the ground.

The Cardinals were 15th in pro football if you examine their defensive abilities, conceding 22.3 points per contest. They gave up an average of 4.6 yds per tote and 126.4 running yards per game for the previous season. On the whole, they surrendered 2,149 yards via the ground game in 17 outings for the previous season. Concerning pass yds, the Cardinals relinquished 3,674 yds putting them 14th in football. They allowed 216.1 yds per contest by way of the pass, and granted a completion percentage 68.6%. Overall, they allowed 342.5 per outing, which was 21st in professional football. They relinquished 20 passing touchdowns, along with 18 to runners.

Get all of our Free NFL Picks

The Saints finished the season with a 5-12 record. In their last contest, the Saints took a loss by a final score of 27-19 when they played the Tampa Bay Buccaneers. Spencer Rattler (1 touchdown) finished the game with 240 yds on 26-42 through the air while his QB rating was 85.4. He kept the ball away from the defense with no picks and his avg yards per attempt was 5.7 yds. Juwan Johnson was the top contributor in the passing game for the Saints, snagging 6 balls for 80 yds (13.3 yards per catch). Clyde Edwards-Helaire carried the rock 8 times for 26 yds, finishing the game with 3.3 yds per carry for New Orleans. The Saints finished with a total of 292 yds while running 61 plays (4.8 yards per play). New Orleans ended up running for 3.4 yards per tote, totaling 64 yds on 19 attempts. New Orleans surrendered 31 rushing attempts for 179 yds (5.8 yds per rush). The Saints passing defense allowed a completion rate of 65.6%, relinquishing 216 yards on 21 out of 32 passing.

The New Orleans Saints averaged 320.1 total yards per outing, which was 21st in professional football. They had an average of 114.9 rushing yds per contest, and ran for 1,954 yds. The New Orleans offense granted 1,003 total yards on 110 violations, which ranked them 17th in professional football if you look at making mistakes. Last year, the Saints threw for a total of 3,488 passing yds and held an average of 205.2 passing yds per outing, which had them ranked 23rd in the NFL. If you examine their scoring prowess, the Saints sat 24th in football, holding an average of 19.9 points per contest.

They surrendered 19 touchdowns through the air along with 238.5 passing yds per game, which had them ranked 27th in the NFL. New Orleans granted a total of 2,404 running yards (141.4 yards per game), plus 20 touchdowns via the ground game for the previous season. The D recorded 17 takeaways (3 fumbles forced and 14 picks) for the previous season. The Saints defense participated in 1,119 plays from scrimmage, which had them ranking 30th in football. The Saints conceded 23.4 points per contest, which had them sitting 19th in pro football.

Who will win tonight's Cardinals-Saints NFL game against the spread?

Tony's Pick: Take the Cardinals -6.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here