Arizona Cardinals vs Seattle Seahawks Prediction, 11/9/2025 NFL Picks, Best Bets & Odds Week 10

Game: Arizona Cardinals vs Seattle Seahawks

Date: Sunday, November 9, 2025

Location: Lumen Field in Seattle, WA

TV: CBS

Odds-Point Spread: Seahawks (-6.5)

Total-Over-Under: 45.5

The Arizona Cardinals (3-5) are hitting the road to Lumen Field on Sunday where they will take on the Seattle Seahawks (6-2). Arizona is 6.5-point dogs. The total is set at 45.5.

The Arizona Cardinals step on the gridiron holding a record of 3-5 on the year. In their last contest, the Cardinals faced the Dallas Cowboys and took home the win by a score of 27-17. Jacoby Brissett connected on 21-31 with 261 yards through the air and 2 TDs. He had a QB rating of 115.1 and finished the game without throwing an interception. Emari Demercado was the rushing leader for the Cardinals with 14 attempts for 79 yards (5.6 yards per carry). Marvin Harrison Jr. averaged 13.7 yds per catch by accounting for 96 yds on 7 receptions. The Arizona Cardinals ended up rushing 29 times and accrued 119 yards, which is an average of 4.1 yards per attempt. Overall, they tallied 60 plays for 340 yds. Arizona relinquished 24 pass completions on 39 attempts for 210 yards, and a completion rate of 61.5%. Against the run, the Cardinals gave up 123 yards on 21 tries, which averages out to 5.9 yards per run allowed.

If you look at scoring points, the team from Arizona average 22.5 points per contest. Collectively, they are sitting at 111.5 rushing yards putting them 20th in professional football. The Cardinals have collected 2,512 yards over the course of the season. Arizona has attained 94 1st downs as an offense, and they have been flagged for 56 penalties for 403 yards. They have coughed up the ball 8 times (4 INTs and 4 fumbles). Regarding scoring touchdowns, Arizona has produced 12 touchdowns through the air and 6 touchdowns on the ground.

If you're looking at passing yards, the Cardinals have granted 1,854 yards, which is 20th in football. They have relinquished 231.8 yards per contest by way of the pass, and are giving up a completion rate of 63.3%. Altogether, they have conceded 829 rushing yards through 8 contests over the course of this year. They have conceded 9 touchdowns via the pass, and 7 touchdowns via the ground game. All in all, they are granting 335.4 yards per contest, putting them 20th in professional football. The opposition is running for an average of 4.3 yds per attempt on the ground and 103.6 running yards per contest for the year. The Cardinals sit 11th in the NFL when talking about the opposition scoring, granting 21.4 points per contest.

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The Seahawks head into this matchup 6-2 over the course of this year. In their last contest, the Seahawks walked away with a victory by a final of 38-14 when they played the Washington Commanders. Sam Darnold (4 TDs) walked away from the contest with 330 yds on 21-24 through the air while his quarterback rating was 141. He threw 1 interception and his average yds per pass attempt was 13.8 yards. Jaxon Smith-Njigba had the best day in terms of receiving for the Seahawks, snagging 8 passes for 129 yds (16.1 yds per reception). Kenneth Walker III carried the ball 11 times for 42 yards, walking away from the game with 3.8 yards per attempt for Seattle. The Seahawks ended up finishing with 418 yards while they ran 48 plays (8.7 yards per play). Seattle ran for 3.7 yds per carry, totaling 88 yds on 24 carries. Seattle relinquished 36 running attempts for 157 yds (4.4 yds per rush). The Seahawks pass defense gave up a completion percentage of 72.7%, surrendering 133 yards on 16 out of 22 through the air.

The Seattle Seahawks average 359.0 yards per contest, which ranks them 9th in the league. They average 103.9 rushing yards per outing, and have toted the ball for 831 total yards. They have thrown 6 INTs while relinquishing 7 fumbles, and have been able to obtain 91 first downs as a team. The Seattle offense has granted 433 yards on 51 violations, which is 25th in football if you analyze making mistakes. So far this year, the Seahawks sit at 2,041 yards via the pass and are sitting at 255.1 yards via the pass per outing, ranking this team at 4th in the NFL. If you look at the points being put on the board, the Seahawks are sitting 5th in the NFL, with an average of 28.9 points per contest.

They have granted 11 touchdowns through the air along with 218.0 passing yards per outing, which is 18th in football. Seattle has conceded a total of 687 rushing yds (85.9 yards per contest), along with 4 touchdowns by way of the ground game over the course of the season. The D currently has 10 turnovers (1 fumble and 9 picks) on the season. Altogether, they have given up 150 points. The Seahawks defense has taken the field for 522 plays from the line of scrimmage, which ranks 20th in football. The Seahawks are giving up 18.8 points per contest, which is 5th in football.

Who will win tonight's Cardinals-Seahawks NFL game against the spread?

Tony's Pick: Take the Seahawks -6.5

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