Buffalo Bills vs Carolina Panthers Prediction, 10/26/2025 NFL Picks, Best Bets & Odds Week 8

Game: Buffalo Bills vs Carolina Panthers

Date: Sunday, October 26, 2025

Location: Bank of America Stadium in Charlotte, NC

TV: FOX

Odds-Point Spread: Panthers (+7.5)

Total-Over-Under: 45.5

The Buffalo Bills (4-2) are hitting the road to Bank of America Stadium on Sunday where they will try to beat the Carolina Panthers (4-3). Carolina is 7.5-point underdogs from Vegas oddsmakers. The betting total comes in at 45.5.

The Buffalo Bills come into this game holding a record of 4-2 over the course of this season. The last time they stepped on the gridiron, the Bills played the Atlanta Falcons and ended up losing by a score of 24-14. Josh Allen went 15-26 with 180 yards passing and 2 TDs. He had a quarterback rating of 72.6 and finished the game with 2 interceptions. James Cook was the best rusher for the Bills with 17 carries for 87 yards (5.1 yds per carry). Khalil Shakir left with an average of 11.0 yards per reception by earning 33 yards on 3 catches. The Buffalo Bills ran the ball a total of 24 times and recorded 134 yds, which earned them an average of 5.6 yds per carry. On the day, they tallied 50 plays for 291 yds. Buffalo allowed 20 completions on 32 attempts for 233 yards, and a completion percentage of 62.5%. On the ground, the Bills gave up 210 yards on 32 tries, which is 6.6 yds per run allowed.

The Bills have a total of 2,270 yds over the course of this season. Buffalo has produced 73 1st downs as a team, and they have been called for 44 infractions for 351 yds. If you're looking at getting the ball in the endzone, Buffalo has produced 11 passing touchdowns and 9 touchdowns via the ground. They have turned the ball over 6 times (4 interceptions and 2 fumbles lost). Collectively, they have an average of 151.0 rush yds which has them sitting 1st in football. When analyzing putting points on the board, the AFC members average 27.8 points per contest.

The Bills currently rank 17th in football concerning their defensive abilities, surrendering 22.8 points per game. They are giving up an average of 5.8 yards per rushing attempt and 156.3 running yards per game over the course of this season. When you look at passing yards, the Bills have given up 1,003 yds, giving them a rank of 2nd in football. They have given up 167.2 yds per outing through the air, and are allowing a completion percentage of 64.2%. On the whole, they are conceding 323.5 yds per outing, which has them sitting 15th in football. They have given up 7 touchdowns through the air, as well as 9 touchdowns to rushers. In total, they have yielded 938 yards via the ground game in 6 outings on the season.

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The Panthers step on the gridiron with a record of 4-3 on the season. In their last contest, the Panthers walked away with a victory by a final of 13-6 when they played the New York Jets. Bryce Young (1 touchdown) finished the contest with 138 yards on 15-25 passing while his QB rate was 88.4. He didn't toss any interceptions and his avg yards per attempt was 5.5 yds. Rico Dowdle ran the football 17 times for 79 yds, finishing the game with 4.6 yds per carry for Carolina. Rico Dowdle was featured in the passing game for the Panthers, catching 1 balls for 17 yds (17.0 yds per catch). Carolina rushed the football for 3.5 yds per attempt, finishing the game with 125 yards on 36 attempts. The Panthers finished the game with 302 yds while they ran 68 plays (4.4 yds per play). The Panthers passing defense allowed a completion percentage of 47.1%, relinquishing 139 yds on 16 for 34 through the air. Carolina conceded 20 rushing attempts for 81 yards (4.1 yards per carry).

The Carolina Panthers average 326.7 yds per contest, which ranks them 19th in professional football. They average 140.1 running yards per contest, and have carried the football for 981 yards. They have a total of 5 interceptions while surrendering 4 lost fumbles, and have obtained 78 1st downs as an offense. The Carolina offense has allowed 350 yards by way of 42 infractions, ranking this team at 27th in the NFL if you're looking at helping out the other team. Over the course of this season, the Panthers have racked up 1,306 yards through the air and hold an average of 186.6 yards through the air per outing, which has them sitting 26th in football. When you look at their ability to score points, the Panthers are 24th in pro football, scoring 20.7 PPG.

The Panthers are surrendering 21.7 points per contest, ranking this team at 13th in the NFL. They have given up 10 touchdowns through the air and 203.1 yards through the air per outing, ranking this team at 10th in the NFL. Carolina has granted a total of 648 running yards (92.6 yards per contest), and 5 touchdowns to runners so far this year. The Panthers defense has participated in 391 plays from scrimmage, which is good for 9th in football. The defense has accrued 7 takeaways (1 fumble and 6 picks) over the course of this year. In total, they have yielded 152 points.

Who will win tonight's Bills-Panthers NFL game against the spread?

Josh's Pick: Take the Panthers +7.5

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