Buffalo Bills vs New England Patriots Prediction, 12/14/2025 NFL Picks, Best Bets & Odds Week 15

Game: Buffalo Bills vs New England Patriots

Date: Sunday, December 14, 2025

Location: Gillette Stadium in Foxborough, MA

TV: CBS

Odds-Point Spread: Patriots (+1)

Total-Over-Under: 49.5

The New England Patriots (11-2) will take on the Buffalo Bills (9-4) at Gillette Stadium on Sunday. Buffalo opens this game as 1-point favorites. The betting total is set at 49.5.

The Buffalo Bills step onto the field holding a record of 9-4 on the campaign. When they last took the field, the Bills played the Cincinnati Bengals and notched a win by a score of 39-34. Josh Allen went 22-28 with 251 yards passing and 3 touchdowns. He had a QB rate of 139.7 and finished the contest with no picks. Dawson Knox had an average of 15.5 yds per catch by accumulating 93 yards on 6 receptions. James Cook was the best rusher for the Bills with 18 attempts for 80 yds (4.4 yds per carry). Overall, they tallied 57 plays which totaled 416 yds. The Buffalo Bills ran the rock 29 times and had 183 yds, which is an average of 6.3 yards per attempt. When it came to the battle of the line of scrimmage, the Bills conceded 62 yds on 19 tries, which is 3.3 yds per run allowed. Buffalo gave up 25 completions on 36 attempts for a total of 276 yards, and a completion rate of 69.4%.

The Bills have recorded 4,988 yards this season. Buffalo has accumulated 152 1st downs offensively, and they have been flagged for 87 infractions for 730 total yards. Concerning scoring touchdowns, Buffalo has racked up 22 passing TD's and 22 ground TD's. They have given the ball to the opposition 18 times (10 interceptions and 8 lost fumbles). As a team, they average 157.8 rushing yards which has them ranked 1st in professional football. When examining scoring points, the Buffalo Bills hold an average of 28.9 points per outing.

When talking about passing yards, the Bills have allowed 2,234 yards, which has them ranked 2nd in football. They have yielded 171.8 total yards per outing via the pass, and are relinquishing a completion% of 60.5%. In total, they have relinquished 1,758 yards via the ground game in 13 games for this campaign. They have surrendered 16 touchdowns by way of the pass, plus 19 touchdowns by way of the ground game. Overall, they are giving up 307.1 yards per outing, which ranks them 10th in the NFL. They are allowing an average of 5.1 yds per run and 135.2 rushing yds per contest on the year. The Bills are 14th in the NFL if you examine the other team scoring points, yielding 22.5 points per outing.

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The Patriots come into this matchup holding a record of 11-2 on the season. In their last contest, the Patriots got the victory with a final of 33-15 when they played the New York Giants. Rhamondre Stevenson carried the football 12 times for 40 yds, finishing the game with 3.3 yds per carry for New England. Hunter Henry was the leading receiver for the Patriots, bringing in 4 passes for 73 yards (18.3 yards per reception). Drake Maye (2 TDs) ended the contest with 282 yards on 24-31 passing while his quarterback rating was 126. He didn't throw any interceptions and his average yards per pass attempt was 9.1 yards. New England conceded 27 run attempts for 111 yards (4.1 yards per rush). The Patriots secondary allowed a completion rate of 70.8%, relinquishing 128 yds on 17 for 24 through the air. The Patriots finished with 395 yds and they ran 60 plays (6.6 yards per play). New England ran for 4.1 yds per carry, finishing the game with 119 yards on 29 attempts.

The New England Patriots have an average of 362.6 yards per game, which has them ranked 8th in football. They average 112.9 rushing yds per outing, and have toted the ball for 1,468 yards. They have compiled 6 interceptions while relinquishing 7 lost fumbles, and have tallied 159 1st downs offensively. The New England offense has granted 667 yards by way of 81 infractions, which has them ranked 23rd in professional football concerning hurting your team. This season, the Patriots have thrown for a total of 3,246 passing yds and are averaging 249.7 passing yds per contest, which ranks them 2nd in the NFL. Concerning this team's ability to score points, the Patriots sit 7th in professional football, maintaining an average of 27.0 points per contest.

They have relinquished 21 touchdowns through the air plus 206.9 pass yards per outing, which ranks them 14th in the NFL. New England has allowed a total of 1,163 rushing yds (89.5 yards per outing), plus 5 touchdowns by way of the ground game on the season. The D has collected 14 turnovers (6 forced fumbles and 8 INTs) for this campaign. On the whole, they have conceded 241 points in total. The Patriots defense has participated in 735 plays from scrimmage, putting them 3rd in professional football. The Patriots are relinquishing 18.5 points per contest, which has them ranked 5th in professional football.

Who will win tonight's Bills-Patriots NFL game against the spread?

Guy's Pick: Take the Bills -1

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