Carolina Panthers vs Arizona Cardinals Prediction, 9/14/2025 NFL Picks, Best Bets & Odds Week 2

Game: Carolina Panthers vs Arizona Cardinals

Date: Sunday, September 14, 2025

Location: State Farm Stadium in Glendale, AZ

TV: CBS

Odds-Point Spread: Cardinals (-6.5)

Total-Over-Under: 44.5

The Arizona Cardinals (1-0) host the Carolina Panthers (0-1) at State Farm Stadium on Sunday. Arizona opens this game as 6.5-point favorites from Vegas oddsmakers. The total comes in at 44.5.

The Carolina Panthers head into this matchup 0-1 for this campaign. When they last took the field, the Panthers faced off with the Jacksonville Jaguars and took a loss by a score of 26-10. Bryce Young finished 18-35 with 154 yards passing and 1 touchdown. He had a quarterback rating of 49 and ended the game with 2 interceptions. Chuba Hubbard led the offense in rushing for the Panthers with 16 attempts for 57 yds (3.6 yds per carry). Tetairoa McMillan had an average of 13.6 yds per catch by totaling 68 yds on 5 catches. The Carolina Panthers ran the rock 25 different times and tallied 113 yds, which came out to an average of 4.5 yards per tote. Once the final whistle blew, they ran 60 plays which totaled 255 yards. Carolina relinquished 19 pass completions on 31 attempts for 178 yards, and a completion rate of 61.3%. When it came to stopping the run, the Panthers gave up 200 yards on 32 tries, which averages out to 6.3 yards per run allowed.

When talking about notching touchdowns, the group from Carolina are averaging 10.0 points per game. Offensively, they're averaging 113.0 rushing yds ranking them 14th in pro football. The Panthers have racked up 255 total yards for this campaign. Carolina has earned 8 first downs offensively, and they have committed 4 penalties for 35 yds. They have surrendered the ball 3 different times. If you analyze scoring touchdowns, Carolina has accumulated 1 passing touchdown and 0 running touchdowns.

If you analyze yards via the pass, the Panthers have yielded 178 yds, which ranks them 13th in the NFL. They are yielding a completion percentage of 61.3%. They have conceded 1 touchdown by way of the pass, in addition to 1 touchdown on the ground. On the whole, they are conceding 378.0 yds per game, putting them 24th in pro football. They are allowing teams to run for an average of 6.3 yds per tote and 200.0 rush yards per outing on the year. The Panthers currently sit 24th in the league when it comes to the opposition scoring, relinquishing 26.0 points per game.

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The Cardinals come into this game with a record of 1-0 for this campaign. In their last contest, the Cardinals got the victory with a final of 20-13 when they played the New Orleans Saints. James Conner carried the ball 12 times for 39 yards, finishing the contest with 3.3 yards per attempt for Arizona. Trey McBride was one of the featured targets for the Cardinals, hauling in 6 throws for 61 yards (10.2 yards per catch). Kyler Murray (2 touchdowns) finished the contest with 163 yards on 21-29 passing while his quarterback rating was 108.8. He didn't throw any picks and his average yards per pass attempt was 5.6 yds. Arizona allowed 22 rush attempts for 107 yds (4.9 yds per rush). The Cardinals passing defense conceded a completion percentage of 58.7%, relinquishing 208 yds on 27 out of 46 passing. The Cardinals finished the game with 276 yds while they ran 56 plays (4.9 yds per play). Arizona rushed the ball for 5.4 yds per carry, finishing with 146 yards on 27 carries.

The Arizona Cardinals have an average of 276.0 total yards per game, ranking them 20th in pro football. They have run for 146 yds. The Arizona offense has yielded 54 total yards by way of 9 penalties, ranking them 10th in pro football when analyzing making mistakes. This year, the Cardinals have compiled 130 passing yds ranking this team at 30th in professional football. If you're looking at the points being put on the board, the Cardinals are 18th in the NFL, averaging 20.0 points per game.

The Cardinals are relinquishing 13.0 points per game, which ranks them 8th in the NFL. They have yielded 0 touchdowns via the pass as well as 208.0 yards through the air per outing, which has them ranking 19th in the league. Arizona has conceded a total of 107 rush yds. The Cardinals defense has been on the field for 69 plays, putting them 26th in pro football. Their defense has yet to take the ball away.

Who will win tonight's Panthers-Cardinals NFL game against the spread?

Josh's Pick: Take the Cardinals -6.5

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