Carolina Panthers vs Jacksonville Jaguars Prediction, 9/7/2025 NFL Picks, Best Bets & Odds Week 1

Game: Carolina Panthers vs Jacksonville Jaguars

Date: Sunday, September 7, 2025

Location: EverBank Stadium in Jacksonville, FL

TV: FOX

Odds-Point Spread: Jaguars (-3.5)

Total-Over-Under: 46.5

The Carolina Panthers (5-12 last season) are headed to EverBank Stadium on Sunday where they will take on the Jacksonville Jaguars (4-13 last year). Jacksonville is 3.5-point favorites. The betting total comes in at 46.5.

The Carolina Panthers wrapped up their year having amassed a 5-12 mark. In their last game, the Panthers faced the Atlanta Falcons and walked away with a win by a score of 44-38. Bryce Young connected on 25-34 with 251 yds passing and 3 TDs. He had a QB rating of 123.5 and walked away from the game with no interceptions. Miles Sanders was the best rusher for the Panthers with 17 attempts for 66 yds (3.9 yds per carry). Jalen Coker left with an average of 8.9 yds per reception by accounting for 62 yards on 7 catches. The Carolina Panthers ended up running the ball 30 times and totaled 155 yards, which earned them an average of 5.2 yards per attempt. In all, they tallied 65 plays which gave them 425 yards. Carolina allowed 21 completions on 38 attempts for 310 yards, and a completion rate of 55.3%. In the running game, the Panthers conceded 227 yards on 38 tries, which calculates to 6.0 yds per rush allowed.

If you examine distribution of touchdowns, the Panthers held an average of 20.1 points per contest. As a team, they had an average of 110.5 rushing yds, putting them 18th in football. The Panthers earned 5,066 yds in the previous season. Carolina had a total of 168 first downs as a team, and they were flagged for 118 infractions for 947 yds. They surrendered the football 22 different times (15 interceptions and 7 fumbles lost). Carolina earned 22 touchdowns through the air and 18 touchdowns via the run.

The Panthers sat 32nd in football when analyzing their defensive prowess, granting 31.4 points per contest. They gave up an average of 5.2 yards per run and 179.8 rush yards per game in the previous season. Altogether, they relinquished 3,057 yards via the running game in 17 matchups in the previous season. If you examine yards via the pass, the Panthers surrendered 3,820 yards which ranked 23rd in professional football. They surrendered 224.7 total yards per contest via the pass, and conceded a completion% 67.9%. In total, they surrendered 404.5 per game, which had them sitting 32nd in the NFL. They granted 35 touchdowns through the air, along with 24 to rushers.

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The Jaguars ended the year having amassed a 4-13 mark. When they last took the field, the Jaguars went home defeated by a final of 26-23 when they played the Indianapolis Colts. Mac Jones (1 touchdown) ended the game with 225 yards on 20-32 through the air while his quarterback rating was 80.9. He threw 1 interception and his average yds per pass attempt was 7.0 yds. Tank Bigsby carried the football 14 times for 39 yards, ending the contest with 2.8 yards per carry for Jacksonville. Brian Thomas was featured in the passing game for the Jaguars, hauling in 7 footballs for 103 yds (14.7 yards per reception). Jacksonville rushed the football for 3.3 yards per attempt, totaling 113 yards on 34 attempts. The Jaguars finished the game with a total of 319 yards while running 66 plays (4.8 yds per play). The Jaguars secondary conceded a completion rate of 57.5%, surrendering 252 yards on 23 for 40 through the air. Jacksonville relinquished 34 attempts on the ground for 177 yds (5.2 yds per rush).

If you examine how much they score, the Jaguars were 26th in pro football, with an average of 18.8 points per contest. Last season, the Jaguars had a previous total of 3,477 passing yards and averaged 204.5 passing yards per contest, which was 24th in professional football. They were sitting at 101.7 running yards per game, and carried the ball for 1,729 yards. The Jacksonville Jaguars averaged 306.2 yds per game, putting them 25th in football. The Jacksonville offense surrendered 787 yds on 99 violations, which had them ranked 26th in the NFL when it comes to making mistakes.

The Jaguars allowed 25.6 points per outing, which was 28th in professional football. They allowed 29 touchdowns through the air as well as 257.4 passing yards per outing, which was 32nd in professional football. Jacksonville surrendered a total of 2,254 rushing yds (132.6 yds per outing), plus 19 touchdowns via the rush last year. The Jaguars defense participated in 1,125 plays from the line of scrimmage, ranking them 31st in football. The D amassed 9 takeaways (3 forced fumbles and 6 interceptions) last year.

Who will win tonight's Panthers-Jaguars NFL game against the spread?

Tony's Pick: Take the Jaguars -3.5

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