Carolina Panthers vs San Francisco 49ers Prediction, 11/24/2025 NFL Picks, Best Bets & Odds Week 12

Game: Carolina Panthers vs San Francisco 49ers

Date: Monday, November 24, 2025

Location: Levi's Stadium in Santa Clara, CA

TV: ESPN

Odds-Point Spread: 49ers (-7)

Total-Over-Under: 48.5

The Carolina Panthers (6-5) are headed to Levi's Stadium on Monday where they will play the San Francisco 49ers (7-4). San Francisco opens this matchup as 7-point favorites from Vegas oddsmakers. The betting total comes in at 48.5.

The Carolina Panthers head into this matchup 6-5 for the year. The last time they stepped on the gridiron, the Panthers played the Atlanta Falcons and notched a win by a score of 30-27. Bryce Young went 31-45 with 448 yds through the air and 3 touchdowns. He had a quarterback rating of 123.2 and walked away from the game with no interceptions. Rico Dowdle led the offense in rushing for the Panthers with 19 totes for 45 yards (2.4 yards per attempt). Tetairoa McMillan had an average of 16.3 yards per catch by earning 130 yds on 8 catches. The Carolina Panthers rushed the ball a total of 25 times and recorded 67 yds, which earned them an average of 2.7 yards per tote. Overall, they had 70 plays which converted into 486 yds. Carolina relinquished 19 completions on 30 tries for 223 yards, and a completion rate of 63.3%. When it came to the battle of the line of scrimmage, the Panthers conceded 125 yds on 28 attempts, which calculates to 4.5 yards per rush allowed.

In terms of putting points on the board, the team repping Carolina are averaging 18.8 points per game. Offensively, they have an average of 127.1 rush yds ranking this team at 9th in pro football. The Panthers have racked up 3,457 yds for this campaign. Carolina has amassed 121 1st downs offensively, and they have been hurt by 60 infractions for 463 total yards. They have turned the ball over 15 different times (8 INTs and 7 lost fumbles). When examining getting in the endzone, Carolina has accrued 15 passing TD's and 7 touchdowns via the ground.

The Panthers are ranked 13th in the league if you're looking at their opponents scoring, relinquishing 22.6 points per game. They are giving up an average of 4.4 yds per run and 113.1 running yds per contest for the year. When it comes to yards via the pass, the Panthers have allowed 2,341 yds, which has them ranking 22nd in football. They have given up 212.8 yds per contest through the air, and are yielding a completion percentage of 64.6%. Overall, they are allowing 325.9 yards per contest, giving them a rank of 15th in the league. They have yielded 13 touchdowns by way of the pass, along with 13 touchdowns by way of the ground game. Altogether, they have yielded 1,244 rushing yards through 11 contests for this campaign.

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The 49ers come into this game with a record of 7-4 on the campaign. The last time they stepped on the football field, the 49ers got the victory with a final of 41-22 against the Arizona Cardinals. Christian McCaffrey carried the ball 13 times for 81 yards, finishing the contest with 6.2 yards per attempt for San Francisco. George Kittle was the best receiver for the 49ers, grabbing 6 footballs for 67 yds (11.2 yards per reception). Brock Purdy (3 TDs) finished the game with 200 yds on 19-26 passing while his quarterback rating was 133.5. He didn't toss any picks and his average yards per pass attempt was 7.7 yds. San Francisco surrendered 14 attempts on the ground for 36 yds (2.6 yards per carry). The 49ers passing defense gave up a completion rate of 82.5%, surrendering 452 yds on 47 out of 57 through the air. The 49ers finished the game with a total of 281 yards and they ran 51 plays (5.5 yards per play). San Francisco ended up running for 3.8 yards per tote, finishing the game with 95 yds on 25 carries.

The San Francisco 49ers maintain an average of 349.4 yards per contest, giving them a rank of 10th in the league. They hold an average of 94.8 rushing yds per contest, and have carried the ball for 1,043 total yards. They have tossed 10 picks while giving up 5 lost fumbles, and have tallied 152 first downs offensively. The San Francisco offense has allowed 482 yards by way of 62 penalty flags, giving them a rank of 23rd in the league when examining giving up free yards. This year, the 49ers have compiled 2,800 yards through the air and are averaging 254.5 yards through the air per contest, ranking them 2nd in the league. Regarding how much they score, the 49ers currently sit 15th in pro football, with 23.7 points per game.

The 49ers are allowing 22.9 points per game, putting them 15th in pro football. They have allowed 21 touchdowns via the pass as well as 249.1 pass yards per game, ranking this team at 28th in pro football. San Francisco has relinquished a total of 1,142 running yds (103.8 yards per contest), in addition to 8 touchdowns to rushers for the year. The 49ers defense has participated in 687 plays, giving them a rank of 31st in the league. The defense has amassed 10 takeaways (7 fumbles forced and 3 interceptions) this year. Overall, they have surrendered 252 points in total.

Who will win tonight's Panthers-49ers NFL game against the spread?

Guy's Pick: Take the 49ers -7

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