Chicago Bears vs San Francisco 49ers Prediction, 12/28/2025 NFL Picks, Best Bets & Odds Week 17

Game: Chicago Bears vs San Francisco 49ers

Date: Sunday, December 28, 2025

Location: Levi's Stadium in Santa Clara, CA

TV: NBC

Odds-Point Spread: 49ers (-3)

Total-Over-Under: 52.5

The San Francisco 49ers (11-4) will go up against the Chicago Bears (11-4) at Levi's Stadium on Sunday. Chicago opens as 3-point underdogs from oddsmakers. The betting total comes in at 52.5.

The Chicago Bears step onto the field holding a record of 11-4 this season. In their last game, the Bears faced off with the Green Bay Packers and went home with a win by a final score of 22-16. Caleb Williams connected on 19-34 with 250 yds through the air and 2 TDs. He had a QB rating of 98.9 and ended the contest without throwing a pick. D.J. Moore averaged 19.4 yds per catch by totaling 97 yards on 5 receptions. D'Andre Swift was the rushing leader for the Bears with 13 carries for 58 yards (4.5 yards per attempt). When all was said and done, they had 60 plays which totaled 400 yds. The Chicago Bears ran the ball 26 different times and accounted for 150 yds, which came out to an average of 5.8 yds per carry. In the running game, the Bears conceded 192 yards on 44 attempts, which is an average of 4.4 yds per rush allowed. Chicago allowed 17 completions on 24 tries for a total of 192 yds, and a completion percentage of 70.8%.

The Bears currently have 5,572 yards on the campaign. Chicago has produced 164 1st downs as a unit, and they have been hurt by 109 penalties for 906 total yards. When it comes to putting the ball in the endzone, Chicago has produced 24 passing touchdowns and 17 rushing touchdowns. They have surrendered the ball 10 times (6 INTs and 4 lost fumbles). As a team, they're sitting at 152.1 rushing yds ranking them 2nd in the league. When it comes to putting the ball in the endzone, the group residing in Chicago are sitting at 25.8 points per contest.

The Bears are ranked 19th in professional football regarding their defensive prowess, conceding 23.6 points per game. They are allowing an average of 5.0 yds per rush on the ground and 131.0 rushing yds per game on the campaign. When it comes to yards through the air, the Bears have yielded 3,256 total yards, which has them ranking 18th in the league. They have granted 217.1 yards per game by way of the pass, and are yielding a completion percentage of 66.4%. On the whole, they are allowing 348.1 yds per contest, which has them ranking 24th in professional football. They have allowed 28 touchdowns by way of the pass, as well as 12 touchdowns by way of the ground game. Altogether, they have yielded 1,965 yards on the ground through 15 outings for this campaign.

Get all of our NFL Picks Against the Spread

The 49ers come into this matchup holding a record of 11-4 this season. In their last contest, the 49ers took home the win by a final score of 48-27 against the Indianapolis Colts. Christian McCaffrey carried the ball 21 times for 117 yards, ending the contest with 5.6 yds per carry for San Francisco. George Kittle was the leading receiver for the 49ers, hauling in 7 footballs for 115 yards (16.4 yards per catch). Brock Purdy (5 touchdowns) walked away from the contest with 295 yds on 25-34 through the air while his QB rate was 126.8. He had 1 pick and his avg yards per attempt was 8.7 yards. San Francisco surrendered 20 rushing attempts for 58 yds (2.9 yards per carry). The 49ers pass defense allowed a completion percentage of 63.9%, relinquishing 254 yards on 23 for 36 passing. The 49ers finished with a total of 440 yds while they ran 65 plays (6.8 yds per play). San Francisco ran the ball for 4.7 yds per carry, totaling 145 yds on 31 carries.

With reference to their ability to score points, the 49ers are ranked 9th in the NFL, with an average of 26.1 points per outing. On the year, the 49ers have earned 3,741 pass yards and hold an average of 249.4 pass yards per outing, which has them sitting 5th in the league. They maintain an average of 104.3 rushing yds per game, and have carried the football for 1,564 yards. The San Francisco 49ers average 353.7 yards per game, which has them ranked 9th in the league. The San Francisco offense has conceded 565 yds by way of 75 infractions, which has them sitting 31st in the league regarding helping out the opposition. They have compiled 14 INTs while allowing 6 fumbles, and have been able to earn 212 1st downs as a team.

The 49ers are surrendering 21.3 points per outing, ranking them 11th in the league. They have yielded 27 touchdowns by way of the pass as well as 229.3 yards through the air per game, which has them ranking 23rd in the league. San Francisco has yielded a total of 1,543 rushing yards (102.9 yards per contest), plus 10 touchdowns to rushers this season. The 49ers defense has been on the field for 897 plays from the line of scrimmage, which has them ranked 9th in the league. Their defense has compiled 16 turnovers (10 forced fumbles and 6 INTs) on the year. Overall, they have surrendered 320 points in total.

Who will win tonight's Bears-49ers NFL game against the spread?

Tony's Pick: Take the 49ers -3

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get NFL picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.