Cincinnati Bengals vs Buffalo Bills Prediction, 12/7/2025 NFL Picks, Best Bets & Odds Week 14

Game: Cincinnati Bengals vs Buffalo Bills

Date: Sunday, December 7, 2025

Location: Highmark Stadium in Orchard Park, NY

TV: FOX

Odds-Point Spread: Bills (-5.5)

Total-Over-Under: 52.5

Highmark Stadium is where the Buffalo Bills (8-4) will play the Cincinnati Bengals (4-8) on Sunday. Cincinnati opens this contest as 5.5-point dogs. The total has been set at 52.5.

The Cincinnati Bengals step on the gridiron holding a record of 4-8 over the course of this year. When they last stepped on the football field, the Bengals played against the Baltimore Ravens and went home with a win by a final score of 32-14. Joe Burrow finished 24-46 with 261 yards passing and 2 TDs. He had a QB rating of 83.7 and ended the game with no picks. Ja'Marr Chase averaged 15.7 yards per reception by accumulating 110 yards on 7 catches. Chase Brown was the leader on the ground for the Bengals with 15 carries for 78 yards (5.2 yards per attempt). On the day, they ran 79 plays which gave them 382 yds. The Cincinnati Bengals ran the ball 33 times and accounted for 128 yds, which earned them an average of 3.9 yds per carry. When it came to the battle of the line of scrimmage, the Bengals gave up 123 yds on 22 tries, which is 5.6 yards per run allowed. Cincinnati relinquished 17 completions on 32 tries for 223 yards, and a completion rate of 53.1%.

The Bengals have a total of 3,760 yards for the season. Cincinnati has recorded 136 first downs as a unit, and they have been flagged for 67 penalties for 485 yards. If you look at getting the ball in the endzone, Cincinnati has racked up 23 touchdowns through the air and 5 running touchdowns. They have given the ball away 18 times (12 interceptions and 6 lost fumbles). Collectively, they hold an average of 88.5 rushing yds which is 30th in the NFL. If you're looking at scoring touchdowns, the AFC representatives have an average of 23.3 PPG.

The Bengals currently sit 32nd in the NFL with reference to their defensive prowess, granting 31.2 PPG. They are giving up 5.1 yards per attempt on the ground and 153.3 running yds per outing over the course of this season. Concerning yards via the pass, the Bengals have allowed 3,081 yds, which has them ranked 32nd in the NFL. They have surrendered 256.8 yds per contest via the pass, and are granting a completion rate of 65.7%. Overall, they are giving up 410.0 yds per game, which is 32nd in the NFL. They have surrendered 26 touchdowns by way of the pass, and 14 touchdowns by way of the ground game. In total, they have surrendered 1,839 rushing yards through 12 outings over the course of this season.

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The Bills come into this game with a record of 8-4 for the season. The last time they stepped on the gridiron, the Bills walked away with a victory by a final of 26-7 when they played the Pittsburgh Steelers. Josh Allen (1 touchdown) ended the game with 123 yards on 15-23 through the air while his quarterback rating was 75.1. He tossed 1 pick and his avg yards per attempt was 5.3 yds. James Cook was a featured target for the Bills, hauling in 3 balls for 33 yds (11.0 yds per reception). James Cook ran the football 32 times for 144 yards, ending the contest with 4.5 yards per attempt for Buffalo. The Bills finished the contest with 372 yds while running 74 plays (5.0 yards per play). Buffalo ran the football for 4.9 yds per carry, finishing with a total of 249 yards on 51 carries. Buffalo relinquished 18 run attempts for 58 yards (3.2 yards per carry). The Bills pass defense allowed a completion rate of 41.7%, surrendering 108 yards on 10 out of 24 passing.

The Buffalo Bills average 381.0 yards per game, which ranks them 2nd in pro football. They average 155.7 rushing yards per game, and have carried the football for 1,868 yards. They have a total of 10 INTs while relinquishing 7 fumbles lost, and have obtained 139 first downs as a team. The Buffalo offense has relinquished 662 total yards by way of 81 penalties, ranking this team at 17th in pro football regarding helping out the opposition. For the season, the Bills have compiled 2,704 passing yds and are averaging 225.3 passing yds per game, which ranks them 10th in pro football. If you're looking at their ability to score points, the Bills currently sit 5th in pro football, by scoring 28.1 PPG.

The Bills are yielding 21.6 points per game, which ranks them 13th in pro football. They have conceded 12 touchdowns through the air in addition to 163.2 passing yds per game, which is 1st in the NFL. Buffalo has relinquished a total of 1,696 rushing yards (141.3 yards per game), and 18 touchdowns on the ground for the season. The Bills defense has participated in 679 plays from scrimmage, which is 3rd in the NFL. The D has produced 15 turnovers (7 fumbles forced and 8 INTs) this year. Overall, they have allowed 259 points.

Who will win tonight's Bengals-Bills NFL game against the spread?

Guy's Pick: Take the Bengals +5.5

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