Cincinnati Bengals vs Denver Broncos Prediction, 9/29/2025 NFL Picks, Best Bets & Odds Week 4

Game: Cincinnati Bengals vs Denver Broncos

Date: Monday, September 29, 2025

Location: Empower Field at Mile High in Denver, CO

TV: ABC

Odds-Point Spread: Broncos (-7)

Total-Over-Under: 44

The Cincinnati Bengals (2-1) are en route to Empower Field at Mile High on Monday where they will take on the Denver Broncos (1-2). Cincinnati opens as 7-point underdogs from oddsmakers. The betting total comes in at 44.

The Cincinnati Bengals head into this matchup 2-1 over the course of this season. In their last contest, the Bengals played the Minnesota Vikings and walked away from this one with a loss by a score of 48-10. Jake Browning went 19-27 with 140 yds through the air and 1 touchdown. He had a quarterback rate of 63.8 and finished the game with 2 picks. Samaje Perine led the offense in rushing for the Bengals with 4 totes for 21 yds (5.3 yds per attempt). Ja'Marr Chase had an average of 10.0 yards per reception by tallying 50 yds on 5 catches. The Cincinnati Bengals ran the football 21 different times and accrued 53 yds, which is an average of 2.5 yards per attempt. Overall, they had 48 plays for 171 yds. Cincinnati relinquished 16 pass completions on 24 tries for 183 yds, and a completion rate of 66.7%. In the running game, the Bengals conceded 169 yards on 31 attempts, which is 5.5 yds per run allowed.

The Bengals have accrued 662 total yards for the season. Cincinnati has tallied 30 first downs as a team, and they have been called for 14 infractions for 107 total yards. Regarding notching touchdowns, Cincinnati has amassed 5 touchdowns via the pass and 2 running touchdowns. They have surrendered the football 8 different times (5 INTs and 3 fumbles). As a unit, they're holding an average of 49.0 rushing yards which ranks them 32nd in football. When examining getting in the endzone, the AFC members have an average of 19.3 points per outing.

When examining yards via the pass, the Bengals have allowed 722 total yards, which ranks them at 25th in football. They have relinquished 240.7 yds per game via the pass, and are allowing a completion% of 64.0%. Overall, they have given up 357 yards via the running game in 3 outings over the course of this year. They have relinquished 6 touchdowns via the pass, in addition to 3 touchdowns on the ground. In total, they are yielding 359.7 total yards per contest, which ranks them at 25th in the NFL. The opposition is running for 4.4 yds per run and 119.0 rushing yds per game so far this year. The Bengals are 26th in the league when you look at team defense, yielding 30.3 points per contest.

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The Broncos step on the gridiron with a record of 1-2 for this campaign. In their last contest, the Broncos took a defeat with a final score of 23-20 when they faced the Los Angeles Chargers. Bo Nix (1 touchdown) finished the contest with 153 yards on 14-25 through the air while his quarterback rating was 87.6. He didn't throw any interceptions and his Y-A was 6.1 yds. Courtland Sutton was one of the featured targets for the Broncos, snagging 6 passes for 118 yards (19.7 yds per catch). J.K. Dobbins ran the ball 11 times for 83 yds, ending the game with 7.5 yds per carry for Denver. The Broncos finished the contest with a total of 265 yds and they ran 46 plays (5.8 yds per play). Denver ran the football for 5.6 yards per tote, totaling 118 yds on 21 carries. Denver relinquished 28 rush attempts for 106 yds (3.8 yds per rush). The Broncos passing defense allowed a completion rate of 59.6%, relinquishing 270 yds on 28 out of 47 passing.

When examining how much they score, the Broncos currently sit 17th in the NFL, scoring 22.7 points per outing. In this season, the Broncos have earned 519 passing yds and have an average of 173.0 passing yds per game, putting them 25th in the NFL. They maintain an average of 129.0 rushing yds per game, and have carried the football for 387 yds. The Denver Broncos have an average of 302.0 yards per outing, which is good for 19th in professional football. The Denver offense has relinquished 218 yards by way of 24 penalty flags, which has them sitting 12th in the league when talking about giving up free yards. They have compiled 3 INTs while giving up 2 fumbles lost, and have obtained 25 first downs as a unit.

They have allowed 2 touchdowns via the pass as well as 212.7 yards via the pass per contest, which has them sitting 18th in pro football. Denver has relinquished a total of 344 rush yds (114.7 total yards per contest), and 2 touchdowns via the ground game over the course of the season. Their defense has tallied 4 takeaways (3 forced fumbles and 1 interception) for this campaign. All in all, they have conceded 64 points in total. The Broncos defense has participated in 202 plays from the line of scrimmage, which has them sitting 29th in the league. The Broncos are surrendering 21.3 points per game, ranking this team at 16th in pro football.

Who will win tonight's Bengals-Broncos NFL game against the spread?

Tony's Pick: Take the Broncos -7

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