Cleveland Browns vs Detroit Lions Prediction, 9/28/2025 NFL Picks, Best Bets & Odds Week 4

Game: Cleveland Browns vs Detroit Lions

Date: Sunday, September 28, 2025

Location: Ford Field in Detroit, MI

TV: FOX

Odds-Point Spread: Lions (-9.5)

Total-Over-Under: 45.5

Ford Field is where the Detroit Lions (2-1) will attempt to defeat the Cleveland Browns (1-2) on Sunday. Detroit is 9.5-point favorites. The total has been set at 45.5.

The Cleveland Browns head into this game 1-2 over the course of this year. The last time they took the field, the Browns took on the Green Bay Packers and went home with a win by a final score of 13-10. Joe Flacco connected on 21-36 with 142 yards passing. He had a QB rating of 55.6 and finished the contest with 1 pick. David Njoku left with an average of 8.0 yds per catch by totaling 40 yards on 5 catches. Quinshon Judkins was the rushing leader for the Browns with 18 carries for 94 yds (5.2 yards per attempt). Once the final whistle blew, they had 55 plays which converted into 221 yds. The Cleveland Browns ran the ball 19 times and compiled 96 yards, which came out to an average of 5.1 yards per tote. On the ground, the Browns gave up 81 yds on 31 tries, which averages out to 2.6 yards per rush surrendered. Cleveland relinquished 18 completions on 25 tries for a total of 149 yds, and a completion percentage of 72.0%.

The Browns have amassed 870 yards for this campaign. Cleveland has attained 30 first downs as a team, and they have been hurt by 21 infractions for 185 yds. If you analyze getting the ball in the endzone, Cleveland has accumulated 3 passing TD's and 2 running touchdowns. They have given the ball away 5 different times (4 interceptions and 1 fumble). As a unit, they're holding an average of 86.7 rushing yards which ranks them 29th in football. Regarding notching touchdowns, the squad repping Cleveland average 15.3 points per contest.

If you analyze pass yds, the Browns have surrendered 441 yards, which ranks them 4th in the league. They have conceded 147.0 yards per outing via the pass, and are allowing a completion percentage of 66.2%. On the whole, they have surrendered 172 yards on the ground through 3 matchups this year. They have allowed 6 touchdowns through the air, in addition to 1 touchdown via the ground game. In total, they are yielding 204.3 total yards per contest, which ranks them at 1st in the NFL. They are allowing teams to run for an average of 2.3 yds per running attempt and 57.3 rushing yards per game over the course of this season. The Browns currently rank 18th in pro football when examining their defensive abilities, surrendering 22.7 points per game.

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The Lions step onto the field with a record of 2-1 over the course of this year. In their last contest, the Lions got the victory with a final of 38-30 when they faced the Baltimore Ravens. Jared Goff (1 TD) finished the game with 202 yds on 20-28 passing while his quarterback rate was 103.6. He didn't toss any picks and his avg yards per attempt was 7.2 yds. Amon-Ra St. Brown was the top contributor in the passing game for the Lions, catching 7 passes for 77 yards (11.0 yards per catch). David Montgomery carried the ball 12 times for 151 yards, ending the contest with 12.6 yds per attempt for Detroit. The Lions finished the game with 426 yards and they ran 66 plays (6.5 yds per play). Detroit ran the ball for 5.9 yds per attempt, finishing with a total of 224 yards on 38 carries. Detroit conceded 19 running attempts for 85 yards (4.5 yards per carry). The Lions secondary conceded a completion percentage of 75.0%, relinquishing 233 yards on 21 for 28 passing.

If you're looking at their ability to score points, the Lions are ranking 2nd in the league, holding an average of 34.3 PPG. For the year, the Lions sit at 736 passing yards and are sitting at 245.3 passing yards per contest, which ranks them at 8th in the NFL. They average 149.0 rushing yards per contest, and have rushed for 447 yards. The Detroit Lions maintain an average of 394.3 yards per game, which ranks them 3rd in the league. The Detroit offense has allowed 136 total yards on 18 violations, which ranks them 23rd in football when it comes to giving up free yards. They have thrown 1 interception while allowing 0 fumbles, and have earned 39 1st downs offensively.

The Lions are yielding 26.0 PPG, which ranks them at 23rd in the NFL. They have surrendered 7 touchdowns by way of the pass in addition to 208.7 yards via the pass per outing, which has them sitting 15th in the league. Detroit has surrendered a total of 297 rush yards (99.0 total yards per contest), as well as 3 touchdowns on the ground for this campaign. The Lions defense has taken the field for 165 plays from the line of scrimmage, which ranks them at 6th in the NFL. The D has a total of 3 turnovers (2 forced fumbles and 1 interception) over the course of the season. In total, they have allowed 78 pts.

Who will win tonight's Browns-Lions NFL game against the spread?

Guy's Pick: Take the Browns +9.5

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