Dallas Cowboys vs Carolina Panthers Prediction, 10/12/2025 NFL Picks, Best Bets & Odds Week 6

Game: Dallas Cowboys vs Carolina Panthers

Date: Sunday, October 12, 2025

Location: Bank of America Stadium in Charlotte, NC

TV: FOX

Odds-Point Spread: Panthers (+3.5)

Total-Over-Under: 49.5

The Dallas Cowboys (2-2) are en route to Bank of America Stadium on Sunday where they will try to defeat the Carolina Panthers (2-3). Dallas opens as 3.5-point favorites from Vegas oddsmakers. The betting total comes in at 49.5.

The Dallas Cowboys head into this matchup 2-2 for the year. When they last took the field, the Cowboys took on the New York Jets and took home the win by a score of 37-22. Dak Prescott finished 18-29 with 237 yds passing and 4 TDs. He had a quarterback rating of 127.4 and ended the contest without throwing a pick. Javonte Williams was the rushing leader for the Cowboys with 16 attempts for 135 yds (8.4 yds per carry). Jake Ferguson had an average of 7.0 yds per reception by recording 49 yards on 7 receptions. The Dallas Cowboys ended up running the ball 29 times and totaled 180 yards, earning them an average of 6.2 yards per attempt. At the end of the game, they ran 58 plays which gave them 416 yards. Dallas surrendered 32 completions on 46 attempts for a total of 234 yards, and a completion percentage of 69.6%. Against the run, the Cowboys conceded 144 yards on 22 attempts, which is an average of 6.5 yds per run surrendered.

The Cowboys currently have 2,033 yds on the campaign. Dallas has recorded 70 1st downs as an offense, and they have been called for 42 infractions for 359 yds. If you're looking at getting the ball into the endzone, Dallas has amassed 10 passing touchdowns and 7 running touchdowns. They have given the ball to the opposition 6 times (4 INTs and 2 fumbles lost). Offensively, they're averaging 134.4 running yds which has them sitting 8th in professional football. If you look at scoring, the team residing in Dallas are sitting at 30.2 points per game.

When talking about pass yards, the Cowboys have relinquished 1,423 yds, putting them 32nd in pro football. They have yielded 284.6 total yards per contest by way of the pass, and are giving up a completion rate of 72.4%. Overall, they have relinquished 637 yards via the ground game in 5 outings so far this season. They have conceded 12 touchdowns through the air, as well as 6 touchdowns to runners. On the whole, they are conceding 412.0 total yards per outing, ranking them 32nd in the NFL. They are allowing 4.4 yards per rush on the ground and 127.4 rushing yds per outing this season. The Cowboys are 29th in the league if you analyze their opponents scoring, surrendering 30.8 points per contest.

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The Panthers step on the gridiron with a record of 2-3 for the year. When they last stepped on the football field, the Panthers took home the win by a final score of 27-24 when they faced the Miami Dolphins. Rico Dowdle ran the football 23 times for 206 yds, finishing the game with 9.0 yards per carry for Carolina. Tetairoa McMillan was a featured target for the Panthers, catching 6 balls for 73 yards (12.2 yards per reception). Bryce Young (2 touchdowns) finished the contest with 198 yards on 19-30 through the air while his quarterback rating was 90.7. He tossed 1 interception and his avg yards per attempt was 6.6 yds. Carolina conceded 14 rushing attempts for 19 yds (1.4 yards per carry). The Panthers secondary gave up a completion rate of 75.0%, relinquishing 229 yds on 27 out of 36 passing. The Panthers ended up finishing with 418 yards while running 62 plays (6.7 yds per play). Carolina ran the football for 7.5 yds per carry, finishing with 239 yards on 32 attempts.

The Carolina Panthers hold an average of 315.0 total yards per outing, which ranks 21st in pro football. They hold an average of 128.0 running yards per game, and have carried the ball for 640 yards. They have recorded 4 picks while relinquishing 4 lost fumbles, and have recorded 57 first downs. The Carolina offense has relinquished 248 total yards on 30 infractions, ranking this team at 28th in the NFL if you look at helping out the opposition. On the season, the Panthers have racked up 935 yards through the air and average 187.0 yards through the air per game, which is 26th in professional football. When talking about their ability to score points, the Panthers currently sit 24th in pro football, with an average of 20.4 PPG.

They have granted 7 touchdowns via the pass as well as 204.4 yards through the air per game, which is 10th in professional football. Carolina has granted a total of 536 rushing yds (107.2 total yards per contest), plus 5 touchdowns via the ground game so far this season. The defense has attained 5 takeaways (1 fumble and 4 picks) so far this year. In total, they have conceded 119 pts. The Panthers defense has taken part in 278 plays from scrimmage, putting them 6th in pro football. The Panthers are conceding 23.8 points per contest, ranking them 19th in the NFL.

Who will win tonight's Cowboys-Panthers NFL game against the spread?

Tony's Pick: Take the Cowboys -3.5

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