Detroit Lions vs Green Bay Packers Prediction, 9/7/2025 NFL Picks, Best Bets & Odds Week 1

Game: Detroit Lions vs Green Bay Packers

Date: Sunday, September 7, 2025

Location: Lambeau Field in Green Bay, WI

TV: CBS

Odds-Point Spread: Packers (-2.5)

Total-Over-Under: 47.5

The Detroit Lions (15-2 last season) are en route to Lambeau Field on Sunday where they will go up against the Green Bay Packers (11-6 last year). Green Bay is 2.5-point favorites. The over-under is set at 47.5.

The Detroit Lions finished the year having notched a 15-2 record. In their last contest, the Lions faced the Washington Commanders and took a loss by a score of 45-31. Jared Goff went 23-40 with 313 yards passing and 1 TD. He had a quarterback rating of 59.7 and ended the contest with 3 picks. Jahmyr Gibbs was the best rusher for the Lions with 14 carries for 105 yds (7.5 yards per attempt). Amon-Ra St. Brown had an average of 17.1 yds per catch by earning 137 yards on 8 catches. The Detroit Lions ended up running the ball 23 different times and totaled 201 yards, which is an average of 8.7 yards per attempt. In all, they had 66 plays for 521 yds. Detroit surrendered 22 completions on 31 attempts for a total of 299 yds, and a completion rate of 71.0%. In the running game, the Lions conceded 182 yards on 42 attempts, which averages out to 4.3 yards per run surrendered.

The Lions notched 6,962 yds for the previous season. Detroit earned 242 1st downs as a team, and they committed 107 penalties for 988 yds. Detroit amassed 39 passing touchdowns and 29 touchdowns via the run. They surrendered the football 15 times (12 picks and 3 fumbles). Collectively, they were sitting at 146.4 rushing yds, which had them ranking 6th in professional football. If you examine getting in the endzone, the group residing in Detroit were sitting at 33.2 points per outing.

The Lions were sitting 7th in football concerning the opposition scoring, allowing 20.1 PPG. They allowed 4.5 yards per attempt on the ground and 98.4 rushing yds per contest for last year. In total, they granted 1,672 yards via the ground game in 17 games in the previous season. When it comes to passing yds, the Lions allowed 4,148 total yards which ranked them 30th in professional football. They surrendered 244.0 yds per game via the pass, and granted a completion% 61.1%. In total, they surrendered 342.4 per game, which had them sitting 20th in the NFL. They surrendered 18 passing TD's, along with 18 via the rush.

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The Packers culminated the season having produced a 11-6 record. In their last game, the Packers walked away with a loss by a score of 22-10 against the Philadelphia Eagles. Josh Jacobs carried the football 18 times for 81 yards, ending the contest with 4.5 yards per attempt for Green Bay. Jayden Reed was featured in the passing game for the Packers, hauling in 4 passes for 46 yds (11.5 yards per catch). Jordan Love ended the game with 212 yds on 20-33 through the air while his quarterback rating was 41.5. He threw 3 interceptions and his average yards per pass attempt was 6.4 yards. Green Bay allowed 34 rushing attempts for 169 yds (5.0 yds per rush). The Packers pass defense conceded a completion rate of 61.9%, surrendering 121 yards on 13 for 21 through the air. The Packers finished the game with a total of 302 yds on 58 plays (5.2 yards per play). Green Bay ran the football for 4.3 yards per attempt, finishing with 107 yds on 25 attempts.

The Green Bay Packers held an average of 370.8 total yards per contest, which had them sitting 5th in pro football. They averaged 146.8 rushing yds per outing, and rushed for 2,496 yds. The Green Bay offense conceded 836 yds by way of 112 infractions, ranking them 11th in football when analyzing helping out the other team. Last year, the Packers threw for a total of 3,807 passing yds and were sitting at 223.9 passing yds per contest, which ranked them 12th in professional football. Regarding the points being put on the board, the Packers ranked 8th in the NFL, with 27.1 points per game.

They relinquished 23 touchdowns via the pass as well as 215.2 pass yards per contest, which had them ranking 13th in football. Green Bay allowed a total of 1,689 rushing yards (99.4 total yards per contest), and 13 touchdowns by way of the ground game last season. Their defense collected 31 takeaways (14 forced fumbles and 17 picks) for last year. The Packers defense was on the field for 1,036 plays from the line of scrimmage, which had them ranking 10th in professional football. The Packers conceded 19.9 points per contest, which had them sitting 6th in pro football.

Who will win tonight's Lions-Packers NFL game against the spread?

Tony's Pick: Take the Lions +2.5

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