Green Bay Packers vs Cleveland Browns Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3

Game: Green Bay Packers vs Cleveland Browns

Date: Sunday, September 21, 2025

Location: Huntington Bank Field in Cleveland, OH

TV: FOX

Odds-Point Spread: Browns (+8)

Total-Over-Under: 42

Huntington Bank Field is the place where the Cleveland Browns (0-2) will try to beat the Green Bay Packers (2-0) on Sunday. Green Bay opens this matchup as 8-point favorites from Vegas oddsmakers. The total comes in at 42.

The Green Bay Packers come into this game holding a record of 2-0 over the course of this year. In their last contest, the Packers played against the Washington Commanders and went home with a win by a final score of 27-18. Jordan Love went 19-31 with 292 yds through the air and 2 TDs. He had a QB rating of 113.9 and ended the game with no interceptions. Josh Jacobs was the rushing leader for the Packers with 23 carries for 84 yards (3.7 yards per attempt). Tucker Kraft held an average of 20.7 yards per reception by earning 124 yards on 6 receptions. The Green Bay Packers ended up rushing 30 different times and accrued 135 yards, which came out to an average of 4.5 yards per tote. For the game, they had 61 plays which gave them 404 yds. Green Bay allowed 24 pass completions on 42 tries for 179 yds, and a completion percentage of 57.1%. On the ground, the Packers conceded 51 yds on 19 attempts, which is 2.7 yards per run allowed.

With reference to scoring touchdowns, the Packers hold an average of 27.0 points per contest. Offensively, they're maintaining an average of 106.5 running yds putting them 18th in pro football. The Packers have produced 670 yds for the season. Green Bay has notched 22 1st downs as a team, and they have committed 14 infractions for 117 yds. They have yet to give the ball away. When analyzing getting the ball into the endzone, Green Bay has accrued 4 touchdowns through the air and 2 touchdowns via the ground.

The Packers are ranked 4th in football concerning their opponents scoring, yielding 15.5 PPG. They are giving up 2.4 yds per tote and 48.5 rushing yds per contest over the course of this year. When examining pass yds, the Packers have relinquished 379 yards, which is good for 10th in football. They have granted 189.5 yds per outing through the air, and are surrendering a completion rate of 67.9%. On the whole, they are relinquishing 238.0 yards per contest, which is 3rd in professional football. They have surrendered 3 touchdowns by way of the pass. In total, they have allowed 97 running yards through 2 contests for the season.

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The Browns step onto the field with a record of 0-2 for the year. The last time they took the field, the Browns went home defeated by a final of 41-17 against the Baltimore Ravens. Joe Flacco (1 TD) ended the contest with 199 yards on 25-45 passing while his quarterback rate was 65. He had 1 interception and his avg yards per attempt was 4.4 yards. Jerry Jeudy was the top contributor in the passing game for the Browns, hauling in 4 balls for 51 yds (12.8 yds per reception). Quinshon Judkins carried the football 10 times for 61 yds, finishing the game with 6.1 yds per carry for Cleveland. The Browns finished the game with a total of 322 yds on 70 plays (4.6 yards per play). Cleveland rushed for 5.2 yards per attempt, finishing the contest with 115 yds on 22 carries. Cleveland conceded 21 run attempts for 45 yds (2.1 yards per rush). The Browns secondary gave up a completion percentage of 65.5%, relinquishing 197 yds on 19 out of 29 through the air.

The Cleveland Browns maintain an average of 324.5 yards per contest, which is 16th in professional football. They maintain an average of 82.0 rushing yards per contest, and have carried the football for 164 yards. They have recorded 23 first downs. The Cleveland offense has surrendered 95 yds by way of 13 penalties, ranking them 22nd in the league if you analyze helping out the other team. On the year, the Browns sit at 485 pass yards and have an average of 242.5 pass yards per contest, which is 10th in professional football. If you analyze their ability to score points, the Browns are ranked 28th in football, by tallying 16.5 PPG.

The Browns are granting 29.0 points per outing, putting them 26th in pro football. They have surrendered 5 touchdowns by way of the pass in addition to 146.0 yards via the pass per game, ranking them 3rd in football. Cleveland has relinquished a total of 91 rushing yds (45.5 yards per game), in addition to 1 touchdown via the ground game so far this season. The Browns defense has taken part in 102 plays from the line of scrimmage, which is 4th in professional football. Their defense has collected 0 takeaways. All in all, they have allowed 58 pts.

Who will win tonight's Packers-Browns NFL game against the spread?

Guy's Pick: Take the Browns +8

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