Houston Texans vs Indianapolis Colts Prediction, 11/30/2025 NFL Picks, Best Bets & Odds Week 13

Game: Houston Texans vs Indianapolis Colts

Date: Sunday, November 30, 2025

Location: Lucas Oil Stadium in Indianapolis, IN

TV: CBS

Odds-Point Spread: Colts (-4.5)

Total-Over-Under: 44.5

The Indianapolis Colts (8-3) are hosting the Houston Texans (6-5) at Lucas Oil Stadium on Sunday. Indianapolis is 4.5-point favorites. The total comes in at 44.5.

The Houston Texans step onto the field holding a record of 6-5 on the year. When they last stepped on the football field, the Texans played the Buffalo Bills and walked away with a win by a score of 23-19. Woody Marks was the rushing leader for the Texans with 16 carries for 74 yds (4.6 yards per carry). Christian Kirk left with an average of 10.8 yards per catch by tallying 54 yds on 5 catches. Davis Mills connected on 16-30 with 153 yards through the air and 2 TDs. He had a quarterback rating of 90 and finished the game with no picks. In the running game, the Texans conceded 143 yards on 24 tries, which averages out to 6.0 yds per rush allowed. Houston surrendered 24 completions on 34 tries for 183 yards, and a completion rate of 70.6%. When the final whistle blew, they had 56 plays which gave them a total of 261 yds. The Houston Texans ran the football 26 times and totaled 108 yds, which is an average of 4.2 yards per attempt.

The Texans have compiled 3,557 yds this season. Houston has attained 123 first downs as a unit, and they have been flagged for 77 penalties for 629 yds. Regarding getting the ball in the endzone, Houston has a total of 16 touchdowns through the air and 5 TD's on the ground. They have surrendered the ball 9 times (6 picks and 3 lost fumbles). As a unit, they have an average of 107.6 running yards which is 23rd in the league. Regarding getting the ball in the endzone, the AFC South members are sitting at 22.1 points per outing.

When analyzing passing yds, the Texans have surrendered 1,893 yds, which has them sitting 3rd in the league. They have relinquished 172.1 yds per contest by way of the pass, and are conceding a completion% of 58.9%. All in all, they have conceded 1,014 rushing yards through 11 matchups for the year. They have yielded 10 touchdowns by way of the pass, along with 9 touchdowns to runners. Altogether, they are allowing 264.3 yds per game, which has them sitting 1st in the league. They are giving up an average of 4.1 yds per rush and 92.2 running yds per outing over the course of this season. The Texans are ranked 2nd in professional football when it comes to opponents scoring, yielding 16.5 points per contest.

Get all of our Free NFL Picks

The Colts head into this matchup 8-3 on the year. The last time they stepped on the gridiron, the Colts took a loss by a final score of 23-20 when they faced the Kansas City Chiefs. Jonathan Taylor ran the football 16 times for 58 yards, walking away from the game with 3.6 yds per attempt for Indianapolis. Michael Pittman Jr. had the best day in terms of receiving for the Colts, catching 5 passes for 27 yards (5.4 yds per reception). Daniel Jones (2 touchdowns) finished the contest with 181 yards on 19-31 through the air while his quarterback rating was 99. He didn't toss any interceptions and his average yds per pass attempt was 5.8 yards. Indianapolis allowed 41 run attempts for 148 yards (3.6 yards per rush). The Colts passing defense gave up a completion rate of 63.0%, surrendering 346 yds on 29 for 46 passing. The Colts finished the game with 255 yds while running 50 plays (5.1 yards per play). Indianapolis ran for 3.9 yards per tote, finishing the contest with 74 yards on 19 carries.

The Indianapolis Colts average 384.0 total yards per contest, which is good for 2nd in professional football. They maintain an average of 138.8 rushing yards per outing, and have rushed for 1,527 yds. They have thrown 7 INTs while granting 5 lost fumbles, and have tallied 137 first downs offensively. The Indianapolis offense has conceded 607 yds by way of 73 penalties, which is 19th in professional football when examining helping out the other team. In this campaign, the Colts have a total of 2,697 yards through the air and are averaging 245.2 yards through the air per contest, which is good for 7th in professional football. If you analyze their ability to score points, the Colts rank 1st in the league, by scoring 31.0 points per outing.

They have surrendered 16 touchdowns via the pass and 245.4 passing yds per game, which has them sitting 28th in the league. Indianapolis has granted a total of 1,071 rushing yards (97.4 yds per outing), in addition to 9 touchdowns by way of the ground game for this campaign. The D has produced 16 takeaways (5 forced fumbles and 11 interceptions) on the year. All in all, they have conceded 229 total points. The Colts defense has taken part in 723 plays, which is 28th in pro football. The Colts are granting 20.8 points per game, which is 9th in the league.

Who will win tonight's Texans-Colts NFL game against the spread?

Tony's Pick: Take the Texans +4.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get NFL picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.