Indianapolis Colts vs Jacksonville Jaguars Prediction, 12/7/2025 NFL Picks, Best Bets & Odds Week 14

Game: Indianapolis Colts vs Jacksonville Jaguars

Date: Sunday, December 7, 2025

Location: EverBank Stadium in Jacksonville, FL

TV: CBS

Odds-Point Spread: Jaguars (+1.5)

Total-Over-Under: 47.5

The Jacksonville Jaguars (8-4) will compete against the Indianapolis Colts (8-4) at EverBank Stadium on Sunday. Indianapolis opens as 1.5-point favorites from oddsmakers. The total comes in at 47.5.

The Indianapolis Colts head into this game 8-4 so far this year. In their last game, the Colts played against the Houston Texans and ended up losing by a score of 20-16. Daniel Jones connected on 14-27 with 201 yards through the air and 2 TDs. He had a quarterback rate of 101 and ended the game with no picks. Jonathan Taylor was the rushing leader for the Colts with 21 totes for 85 yards (4.0 yards per carry). Alec Pierce averaged 19.5 yds per catch by totaling 78 yards on 4 receptions. The Indianapolis Colts ended up rushing 23 different times and accumulated 86 yards, which is an average of 3.7 yards per attempt. In the game, they ran 50 plays which gave them a total of 281 yds. Indianapolis gave up 22 pass completions on 35 attempts for 256 yards, and a completion rate of 62.9%. When it came to the battle of the line of scrimmage, the Colts gave up 108 yards on 34 tries, which is 3.2 yds per rush surrendered.

When talking about scoring touchdowns, the Colts average 29.8 points per outing. Offensively, they hold an average of 134.4 running yards which has them ranked 6th in pro football. The Colts have earned 4,505 total yards this season. Indianapolis has tallied 146 first downs as a unit, and they have been called for 78 infractions for 640 yds. They have given the ball away 12 different times (7 interceptions and 5 lost fumbles). Regarding scoring touchdowns, Indianapolis has produced 19 touchdowns via the pass and 22 touchdowns on the ground.

The Colts currently rank 9th in pro football concerning team defense, conceding 20.8 points per game. They are allowing teams to run for an average of 3.9 yds per running attempt and 98.3 rushing yards per contest this season. When examining passing yards, the Colts have allowed 2,955 total yards, which has them ranked 25th in pro football. They have relinquished 246.3 yds per contest by way of the pass, and are granting a completion percentage of 63.9%. All in all, they are giving up 344.5 yds per contest, which is good for 21st in pro football. They have surrendered 16 touchdowns by way of the pass, along with 11 touchdowns via the ground game. In total, they have surrendered 1,179 rushing yards through 12 outings over the course of this season.

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The Jaguars come into this game with a record of 8-4 for the season. In their last game, the Jaguars took home the win by a final score of 25-3 when they played the Tennessee Titans. Trevor Lawrence (2 TDs) finished the game with 229 yds on 16-27 passing while his quarterback rate was 111.5. He didn't throw any interceptions and his average yards per pass attempt was 8.5 yds. Travis Etienne carried the rock 12 times for 28 yds, ending the game with 2.3 yards per carry for Jacksonville. Jakobi Meyers was the best receiver for the Jaguars, catching 6 balls for 90 yds (15.0 yds per catch). Jacksonville rushed for 2.6 yards per carry, finishing the game with 70 yards on 27 carries. The Jaguars finished the contest with a total of 272 yds while running 54 plays (5.0 yards per play). The Jaguars pass defense gave up a completion rate of 63.2%, relinquishing 121 yards on 24 out of 38 passing. Jacksonville relinquished 14 run attempts for 67 yards (4.8 yds per rush).

If you're looking at their scoring prowess, the Jaguars are ranked 11th in the NFL, with an average of 24.3 PPG. In this season, the Jaguars have thrown for 2,433 passing yards and hold an average of 202.8 passing yards per outing, which is 21st in professional football. They maintain an average of 123.3 running yds per outing, and have rushed for 1,479 yards. The Jacksonville Jaguars maintain an average of 326.0 total yards per game, which has them ranked 19th in pro football. The Jacksonville offense has conceded 861 yds on 104 violations, which is 1st in the NFL with reference to making mistakes. They have allowed 11 interceptions while allowing 3 fumbles, and have obtained 129 first downs as a unit.

They have conceded 22 touchdowns by way of the pass as well as 230.1 yards through the air per outing, putting them 23rd in pro football. Jacksonville has yielded a total of 989 running yards (82.4 yds per contest), as well as 7 touchdowns to rushers over the course of this season. The D has tallied 20 turnovers (7 forced fumbles and 13 interceptions) over the course of this year. In total, they have surrendered 253 total points. The Jaguars defense has taken part in 732 plays, which has them ranked 11th in pro football. The Jaguars are granting 21.1 points per game, putting them 12th in pro football.

Who will win tonight's Colts-Jaguars NFL game against the spread?

Guy's Pick: Take the Jaguars +1.5

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