Indianapolis Colts vs Kansas City Chiefs Prediction, 11/23/2025 NFL Picks, Best Bets & Odds Week 12

Game: Indianapolis Colts vs Kansas City Chiefs

Date: Sunday, November 23, 2025

Location: GEHA Field at Arrowhead Stadium in Kansas City, MO

TV: CBS

Odds-Point Spread: Chiefs (-3)

Total-Over-Under: 50.5

GEHA Field at Arrowhead Stadium is the location where the Kansas City Chiefs (5-5) will go up against the Indianapolis Colts (8-2) on Sunday. Kansas City opens this game as 3-point favorites from Vegas oddsmakers. The total is 50.5.

The Indianapolis Colts step onto the field holding a record of 8-2 for this campaign. The last time they stepped on the football field, the Colts took the field against the Atlanta Falcons and walked away with a win by a score of 31-25. Jonathan Taylor was the rushing leader for the Colts with 32 attempts for 244 yds (7.6 yards per attempt). Tyler Warren averaged 12.4 yards per catch by tallying 99 yards on 8 catches. Daniel Jones went 19-26 with 255 yards passing and 1 touchdown. He had a QB rating of 100.6 and ended the game with 1 pick. On the ground, the Colts gave up 140 yards on 29 tries, which is an average of 4.8 yds per run allowed. Indianapolis surrendered 12 completions on 28 tries for 150 yds, and a completion rate of 42.9%. When all was said and done, they ran 67 plays which converted into 519 yards. The Indianapolis Colts ran the ball 41 times and tallied 323 yards, which is an average of 7.9 yards per carry.

Regarding putting the ball in the endzone, the Indianapolis Colts are averaging 32.1 points per game. As a unit, they're maintaining an average of 145.3 running yards which has them ranking 3rd in the league. The Colts have notched 3,969 yds on the season. Indianapolis has collected 131 first downs offensively, and they have been hurt by 62 penalties for 524 yds. They have coughed up the ball 12 times (7 INTs and 5 lost fumbles). When examining scoring points, Indianapolis has a total of 15 passing TD's and 22 TD's on the ground.

The Colts sit 9th in the league when talking about the other team scoring points, conceding 20.6 points per outing. They are giving up an average of 4.1 yds per rush on the ground and 92.3 running yds per outing for this campaign. When talking about passing yards, the Colts have surrendered 2,353 yards, giving them a rank of 23rd in the league. They have granted 235.3 total yards per contest via the pass, and are giving up a completion percentage of 64.1%. Altogether, they are conceding 327.6 yds per outing, ranking this team at 19th in the league. They have surrendered 16 touchdowns via the pass, along with 8 touchdowns to runners. Altogether, they have yielded 923 rushing yards through 10 contests for this campaign.

Get all of our Free NFL Picks

The Chiefs come into this matchup holding a record of 5-5 on the season. When they last stepped on the football field, the Chiefs took a loss by a score of 22-19 against the Denver Broncos. Patrick Mahomes (1 touchdown) walked away from the contest with 276 yds on 29-45 passing while his QB rate was 79.5. He tossed 1 pick and his average yards per pass attempt was 6.1 yards. Travis Kelce was featured in the passing game for the Chiefs, snagging 9 footballs for 91 yards (10.1 yds per catch). Kareem Hunt ran the ball 13 times for 59 yds, ending the game with 4.5 yards per carry for Kansas City. The Chiefs finished with 311 yards on 59 plays (5.3 yards per play). Kansas City ran the ball for 4.4 yds per carry, finishing with a total of 62 yards on 14 carries. Kansas City gave up 21 attempts on the ground for 59 yards (2.8 yards per rush). The Chiefs pass defense conceded a completion rate of 63.2%, surrendering 283 yds on 24 out of 38 through the air.

The Kansas City Chiefs average 364.2 total yards per game, putting them 7th in pro football. They have an average of 115.3 running yds per outing, and have toted the ball for 1,153 yds. They have allowed 6 interceptions while conceding 0 fumbles lost, and have obtained 130 1st downs offensively. The Kansas City offense has conceded 577 total yards on 69 penalties, putting them 16th in pro football when it comes to helping out the opposition. This year, the Chiefs have compiled 2,489 yards through the air and are averaging 248.9 yards through the air per contest, ranking them 5th in the league. Regarding how much they score, the Chiefs currently sit 9th in pro football, with 25.4 points per game.

They have relinquished 9 touchdowns via the pass plus 196.8 passing yds per game, putting them 11th in pro football. Kansas City has conceded a total of 1,000 rushing yds (100.0 yds per game), as well as 10 touchdowns to rushers so far this year. The defense has tallied 9 takeaways (3 fumbles forced and 6 interceptions) on the season. On the whole, they have relinquished 181 total points. The Chiefs defense has participated in 548 plays, giving them a rank of 1st in the league. The Chiefs are yielding 18.1 PPG, which has them sitting 4th in football.

Who will win tonight's Colts-Chiefs NFL game against the spread?

Tony's Pick: Take the Colts +3

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get NFL picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.