Indianapolis Colts vs Los Angeles Chargers Prediction, 10/19/2025 NFL Picks, Best Bets & Odds Week 7

Game: Indianapolis Colts vs Los Angeles Chargers

Date: Sunday, October 19, 2025

Location: SoFi Stadium in Inglewood, CA

TV: CBS

Odds-Point Spread: Chargers (-1.5)

Total-Over-Under: 48.5

The Los Angeles Chargers (4-2) are welcoming the Indianapolis Colts (5-1) at SoFi Stadium on Sunday. Indianapolis opens this contest as 1.5-point underdogs from oddsmakers. The betting total is set at 48.5.

The Indianapolis Colts come into this game holding a record of 5-1 this year. The last time they stepped on the gridiron, the Colts faced the Arizona Cardinals and notched a win by a score of 31-27. Daniel Jones went 22-30 with 212 yds passing and 2 touchdowns. He had a quarterback rating of 101 and finished the game with 1 interception. Jonathan Taylor led the offense in rushing for the Colts with 21 attempts for 123 yds (5.9 yards per attempt). Tyler Warren held an average of 10.5 yards per catch by accumulating 63 yards on 6 receptions. The Indianapolis Colts ran the football 27 different times and recorded 150 yds, which earned them an average of 5.6 yards per attempt. Overall, they tallied 57 plays for 355 yds. Indianapolis allowed 27 pass completions on 44 tries for a total of 312 yards, and a completion percentage of 61.4%. Against the run, the Colts conceded 88 yards on 24 tries, which calculates to 3.7 yds per rush allowed.

When talking about notching touchdowns, the AFC South representatives average 32.3 points per contest. As a team, they have an average of 131.8 rush yards which has them ranked 6th in football. The Colts have notched 2,261 yards on the year. Indianapolis has accumulated 76 first downs, and they have been called for 44 infractions for 341 yards. They have turned the football over 4 times (3 interceptions and 1 fumble). When you look at scoring points, Indianapolis has produced 8 passing touchdowns and 13 touchdowns on the ground.

The Colts are ranking 4th in professional football in terms of the opposition scoring, conceding 19.3 PPG. Opposing teams are running for an average of 4.3 yards per run and 96.3 rush yards per outing this year. If you look at pass yds, the Colts have relinquished 1,397 yards, ranking them 23rd in pro football. They have granted 232.8 yds per outing through the air, and are conceding a completion rate of 65.9%. In total, they are allowing 329.2 yards per game, which ranks 19th in the league. They have allowed 10 touchdowns through the air, plus 3 touchdowns to rushers. On the whole, they have surrendered 578 yards via the ground game in 6 matchups on the campaign.

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The Chargers come into this game with a record of 4-2 on the year. In their last contest, the Chargers took home the win by a final score of 29-27 when they played the Miami Dolphins. Kimani Vidal carried the football 18 times for 124 yards, ending the contest with 6.9 yds per carry for Los Angeles. Ladd McConkey was the leading receiver for the Chargers, catching 7 throws for 100 yards (14.3 yards per reception). Justin Herbert (2 TDs) ended the contest with 264 yards on 29-38 passing while his QB rating was 112.2. He kept the ball away from the defense with no interceptions and his Y-A was 6.9 yards. Los Angeles conceded 21 rushing attempts for 137 yds (6.5 yards per rush). The Chargers pass defense allowed a completion rate of 66.7%, relinquishing 204 yards on 22 out of 33 passing. The Chargers finished the contest with a total of 403 yds while they ran 63 plays (6.4 yds per play). Los Angeles ran for 5.6 yds per attempt, finishing with a total of 140 yds on 25 carries.

When talking about this team's ability to score points, the Chargers are ranking 23rd in the league, maintaining an average of 21.2 points per contest. This year, the Chargers have thrown for a total of 1,440 passing yds and have an average of 240.0 passing yds per outing, ranking them 9th in football. They maintain an average of 120.7 rushing yds per contest, and have carried the football for 724 total yards. The Los Angeles Chargers have an average of 360.7 yards per contest, which has them sitting 7th in the league. The Los Angeles offense has relinquished 344 yards by way of 46 penalties, ranking them 9th in professional football in terms of helping out the opposition. They have a total of 4 interceptions while giving up 4 lost fumbles, and have been able to earn 72 first downs as a unit.

They have conceded 5 touchdowns via the pass as well as 177.5 passing yds per contest, which has them sitting 6th in the league. Los Angeles has relinquished a total of 745 rushing yds (124.2 total yards per contest), plus 7 touchdowns via the rush over the course of this season. The D has collected 7 takeaways so far this season. All in all, they have given up 125 total points. The Chargers defense has participated in 351 plays, which has them ranked 13th in football. The Chargers are surrendering 20.8 PPG, ranking them 12th in the NFL.

Who will win tonight's Colts-Chargers NFL game against the spread?

Tony's Pick: Take the Chargers -1.5

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