Indianapolis Colts vs Los Angeles Rams Prediction, 9/28/2025 NFL Picks, Best Bets & Odds Week 4

Game: Indianapolis Colts vs Los Angeles Rams

Date: Sunday, September 28, 2025

Location: SoFi Stadium in Inglewood, CA

TV: FOX

Odds-Point Spread: Rams (-3.5)

Total-Over-Under: 49.5

SoFi Stadium is the place where the Los Angeles Rams (2-1) will attempt to defeat the Indianapolis Colts (3-0) on Sunday. Indianapolis is 3.5-point dogs. The total is set at 49.5.

The Indianapolis Colts head into this game 3-0 so far this year. The last time they stepped on the gridiron, the Colts played the Tennessee Titans and walked away with a win by a score of 41-20. Daniel Jones went 18-25 with 228 yards passing and 1 TD. He had a QB rating of 113.4 and finished the contest with no picks. Jonathan Taylor was the leader on the ground for the Colts with 17 carries for 102 yards (6.0 yds per carry). Michael Pittman Jr. had an average of 12.2 yds per reception by accumulating 73 yards on 6 catches. The Indianapolis Colts ended up rushing 28 times and accounted for 137 yds, which earned them an average of 4.9 yards per attempt. In all, they had 53 plays which gave them a total of 365 yds. Indianapolis allowed 23 pass completions on 38 attempts for a total of 196 yards, and a completion rate of 60.5%. On the ground, the Colts conceded 86 yards on 23 tries, which calculates to 3.7 yards per rush allowed.

When examining getting in the endzone, the AFC South members are sitting at 34.3 points per outing. Offensively, they're averaging 153.3 rush yards which has them sitting 3rd in pro football. The Colts have accrued 1,256 total yards for the season. Indianapolis has attained 40 first downs as a team, and they have been hurt by 19 infractions for 136 yds. They have yet to turn the ball over. If you're looking at getting the ball in the endzone, Indianapolis has compiled 3 passing TD's and 6 ground TD's.

The Colts are ranked 10th in the NFL concerning their defensive abilities, yielding 18.7 PPG. They are giving up 4.8 yds per running attempt and 94.0 rush yards per outing on the year. When examining yards via the pass, the Colts have allowed 535 total yards, which ranks them at 8th in football. They have allowed 178.3 total yards per contest through the air, and are giving up a completion percentage of 64.6%. Overall, they are surrendering 272.3 total yards per outing, ranking this team at 7th in pro football. They have surrendered 5 touchdowns through the air, as well as 2 touchdowns on the ground. All in all, they have conceded 282 rushing yards through 3 contests for this campaign.

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The Rams step onto the field with a record of 2-1 over the course of this season. The last time they stepped on the gridiron, the Rams went home defeated by a final of 33-26 against the Philadelphia Eagles. Matthew Stafford (2 TDs) ended the contest with 196 yds on 19-33 passing while his QB rating was 82.4. He threw 1 pick and his avg yards per attempt was 5.9 yds. Kyren Williams carried the rock 20 times for 94 yds, walking away from the contest with 4.7 yds per attempt for Los Angeles. Puka Nacua was featured in the passing game for the Rams, catching 11 footballs for 112 yds (10.2 yds per catch). Los Angeles ran the ball for 5.2 yds per carry, finishing with a total of 160 yards on 31 carries. The Rams finished the game with a total of 356 yards while running 65 plays (5.5 yds per play). The Rams secondary gave up a completion percentage of 65.6%, surrendering 202 yards on 21 out of 32 through the air. Los Angeles gave up 27 rushing attempts for 86 yards (3.2 yards per rush).

If you analyze how much they score, the Rams are 11th in the league, scoring 24.3 points per contest. Over the course of this season, the Rams have racked up 710 yards via the pass and are averaging 236.7 yards via the pass per contest, which is 10th in the league. They maintain an average of 127.0 rush yards per contest, and have toted the ball for 381 total yards. The Los Angeles Rams maintain an average of 363.7 total yards per game, which ranks them 5th in football. The Los Angeles offense has yielded 130 total yards on 15 infractions, ranking this team at 27th in pro football when examining giving up free yards. They have a total of 2 INTs while allowing 1 fumble, and have obtained 35 1st downs as an offense.

They have conceded 4 touchdowns through the air plus 165.3 yards via the pass per contest, which is 6th in the league. Los Angeles has yielded a total of 309 rushing yards (103.0 total yards per outing), in addition to 1 touchdown by way of the ground game over the course of this year. The D has a total of 4 turnovers (3 forced fumbles and 1 interception) over the course of the season. On the whole, they have surrendered 61 points. The Rams defense has participated in 184 plays from scrimmage, which ranks them 19th in the league. The Rams are allowing 20.3 points per contest, which ranks them 14th in the league.

Who will win tonight's Colts-Rams NFL game against the spread?

Tony's Pick: Take the Rams -3.5

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