Indianapolis Colts vs Pittsburgh Steelers Prediction, 11/2/2025 NFL Picks, Best Bets & Odds Week 9

Game: Indianapolis Colts vs Pittsburgh Steelers

Date: Sunday, November 2, 2025

Location: Acrisure Stadium in Pittsburgh, PA

TV: CBS

Odds-Point Spread: Steelers (+3)

Total-Over-Under: 50.5

The Indianapolis Colts (7-1) are on their way to Acrisure Stadium on Sunday where they will play the Pittsburgh Steelers (4-3). Pittsburgh opens as 3-point underdogs. The total has been set at 50.5.

The Indianapolis Colts head into this game 7-1 this season. In their last game, the Colts took on the Tennessee Titans and took home the win by a score of 38-14. Daniel Jones finished 21-29 with 272 yds passing and 3 touchdowns. He had a quarterback rate of 136 and walked away from the game without throwing an interception. Jonathan Taylor led the offense in rushing for the Colts with 12 carries for 153 yds (12.8 yds per attempt). Michael Pittman Jr. averaged 11.9 yds per reception by tallying 95 yds on 8 receptions. The Indianapolis Colts ended up running the ball 18 different times and accumulated 164 yards, which is an average of 9.1 yds per carry. When all was said and done, they ran 49 plays for 420 yards. Indianapolis relinquished 22 pass completions on 38 attempts for 228 yards, and a completion percentage of 57.9%. When it came to stopping the run, the Colts gave up 113 yards on 25 tries, which calculates to 4.5 yards per rush allowed.

When examining scoring points, the Colts average 33.8 points per outing. Offensively, they hold an average of 134.4 rush yds ranking this team at 6th in football. The Colts have amassed 3,082 yds so far this year. Indianapolis has produced 104 1st downs as a team, and they have been flagged for 50 penalties for 415 yds. They have turned the football over 4 times (3 picks and 1 fumble). When examining getting the ball into the endzone, Indianapolis has accumulated 13 touchdowns through the air and 18 touchdowns via the run.

When it comes to yards via the pass, the Colts have given up 2,016 total yards, which has them ranked 30th in the NFL. They have conceded 252.0 yards per contest via the pass, and are giving up a completion rate of 65.2%. Overall, they have yielded 745 rushing yards through 8 matchups for this campaign. They have yielded 14 touchdowns via the pass, and 4 touchdowns to runners. In total, they are giving up 345.1 total yards per contest, which has them sitting 24th in the league. They are allowing teams to run for an average of 4.3 yds per rush on the ground and 93.1 rushing yards per contest this year. The Colts rank 6th in pro football if you examine team defense, conceding 19.3 PPG.

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The Steelers come into this matchup holding a record of 4-3 so far this year. When they last took the field, the Steelers took a defeat with a final score of 35-25 when they faced the Green Bay Packers. Aaron Rodgers (2 touchdowns) finished the contest with 219 yards on 24-36 through the air while his QB rating was 101.5. He didn't toss any interceptions and his avg yards per attempt was 6.1 yds. D.K. Metcalf was the top contributor in the passing game for the Steelers, snagging 5 passes for 55 yds (11.0 yds per reception). Jaylen Warren carried the ball 13 times for 62 yards, finishing the contest with 4.8 yards per carry for Pittsburgh. The Steelers finished with 295 yards on 54 plays (5.5 yards per play). Pittsburgh ran for 5.2 yards per carry, finishing with 93 yds on 18 attempts. Pittsburgh conceded 26 running attempts for 94 yards (3.6 yds per rush). The Steelers pass defense gave up a completion rate of 78.4%, relinquishing 360 yds on 29 out of 37 passing.

When analyzing their ability to score points, the Steelers currently sit 11th in football, scoring 25.0 points per outing. So far this season, the Steelers have compiled 1,420 yards via the pass and have an average of 202.9 yards via the pass per contest, which has them sitting 19th in the league. They average 94.3 rush yards per game, and have carried the ball for 660 yds. The Pittsburgh Steelers have an average of 297.1 total yards per game, which has them ranked 25th in professional football. The Pittsburgh offense has surrendered 318 yds on 42 penalties, which is good for 29th in football if you examine helping out the other team. They have recorded 5 INTs while relinquishing 1 fumble, and have tallied 64 first downs offensively.

The Steelers are relinquishing 25.0 points per contest, which has them ranked 22nd in the NFL. They have conceded 13 touchdowns via the pass plus 273.3 passing yards per contest, giving them a rank of 32nd in the NFL. Pittsburgh has granted a total of 789 running yards (112.7 total yards per game), as well as 5 touchdowns by way of the ground game so far this season. The Steelers defense has taken the field for 479 plays, putting them 20th in pro football. The defense has accumulated 10 turnovers (5 fumbles forced and 5 INTs) this year. In total, they have conceded 175 pts.

Who will win tonight's Colts-Steelers NFL game against the spread?

Guy's Pick: Take the Steelers +3

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