Indianapolis Colts vs Seattle Seahawks Prediction, 12/14/2025 NFL Picks, Best Bets & Odds Week 15

Game: Indianapolis Colts vs Seattle Seahawks

Date: Sunday, December 14, 2025

Location: Lumen Field in Seattle, WA

TV: CBS

Odds-Point Spread: Seahawks (-13.5)

Total-Over-Under: 42.5

The Seattle Seahawks (10-3) will take on the Indianapolis Colts (8-5) at Lumen Field on Sunday. Seattle is 13.5-point favorites from Vegas oddsmakers. The total is set at 42.5.

The Indianapolis Colts head into this matchup 8-5 for this campaign. In their last game, the Colts played the Jacksonville Jaguars and walked away from this one with a loss by a score of 36-19. Riley Leonard went 18-29 with 145 yards passing. He had a quarterback rate of 60.3 and ended the contest with 1 pick. Michael Pittman Jr. averaged 8.8 yards per reception by recording 79 yards on 9 catches. Jonathan Taylor was the rushing leader for the Colts with 21 attempts for 74 yds (3.5 yards per carry). When all was said and done, they ran 62 plays which gave them 285 yards. The Indianapolis Colts ran the football 26 times and recorded 89 yds, which is an average of 3.4 yards per carry. In the running game, the Colts conceded 103 yds on 32 tries, which is 3.2 yards per run surrendered. Indianapolis conceded 18 completions on 31 attempts for a total of 247 yards, and a completion rate of 58.1%.

Regarding scoring touchdowns, the AFC members are averaging 28.9 points per outing. Offensively, they have an average of 130.9 rushing yds which ranks them 6th in the NFL. The Colts have accrued 4,790 yds on the year. Indianapolis has earned 158 1st downs as a team, and they have committed 83 penalties for 685 yards. They have coughed up the ball 15 different times (9 INTs and 6 fumbles). Regarding scoring touchdowns, Indianapolis has earned 19 touchdowns through the air and 24 TD's on the ground.

If you analyze passing yards, the Colts have allowed 3,202 yds, giving them a rank of 29th in pro football. They have allowed 246.3 yards per game through the air, and are granting a completion rate of 63.5%. Overall, they have surrendered 1,282 rushing yards through 13 games over the course of this year. They have allowed 18 touchdowns through the air, and 13 touchdowns by way of the ground game. On the whole, they are allowing 344.9 yards per contest, which ranks them 23rd in the league. They are allowing an average of 3.8 yds per attempt on the ground and 98.6 rushing yards per game for this campaign. The Colts are sitting 13th in the NFL when it comes to opponents scoring, conceding 21.9 points per outing.

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The Seahawks come into this matchup holding a record of 10-3 this season. The last time they stepped on the gridiron, the Seahawks got the win with a final of 37-9 against the Atlanta Falcons. Sam Darnold (3 TDs) ended the game with 249 yds on 20-30 passing while his QB rate was 111.7. He tossed 1 pick and his average yards per pass attempt was 8.3 yds. Jaxon Smith-Njigba was featured in the passing game for the Seahawks, hauling in 7 throws for 92 yards (13.1 yds per catch). Kenneth Walker III carried the football 10 times for 29 yards, ending the contest with 2.9 yards per carry for Seattle. The Seahawks finished the contest with a total of 365 yds and they ran 56 plays (6.5 yds per play). Seattle rushed for 5.0 yards per carry, finishing the contest with 129 yards on 26 attempts. Seattle allowed 31 rushing attempts for 120 yards (3.9 yards per rush). The Seahawks passing defense conceded a completion percentage of 50.0%, relinquishing 154 yds on 15 out of 30 through the air.

The Seattle Seahawks have an average of 353.5 total yards per outing, putting them 9th in professional football. They average 117.8 rushing yards per game, and have carried the football for 1,532 yds. They have a total of 12 picks while conceding 11 fumbles lost, and have been able to obtain 140 1st downs. The Seattle offense has granted 654 yards by way of 81 infractions, which has them ranked 22nd in professional football concerning hurting your team. For the season, the Seahawks have compiled 3,063 passing yards and average 235.6 passing yards per contest, giving them a rank of 9th in pro football. Regarding their scoring prowess, the Seahawks are 2nd in the NFL, by tallying 29.8 points per outing.

The Seahawks are allowing 17.4 points per game, which ranks them 2nd in the league. They have conceded 16 touchdowns by way of the pass as well as 197.1 passing yds per contest, which ranks them 11th in the NFL. Seattle has relinquished a total of 1,185 rush yards (91.2 yds per contest), as well as 7 touchdowns via the rush over the course of the season. The Seahawks defense has participated in 825 plays from scrimmage, putting them 25th in professional football. Their defense has tallied 21 turnovers (6 forced fumbles and 15 interceptions) on the year. Overall, they have relinquished 226 total points.

Who will win tonight's Colts-Seahawks NFL game against the spread?

Guy's Pick: Take the Seahawks -13.5

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