Jacksonville Jaguars vs Arizona Cardinals Prediction, 11/23/2025 NFL Picks, Best Bets & Odds Week 12

Game: Jacksonville Jaguars vs Arizona Cardinals

Date: Sunday, November 23, 2025

Location: State Farm Stadium in Glendale, AZ

TV: CBS

Odds-Point Spread: Cardinals (+2.5)

Total-Over-Under: 47.5

The Jacksonville Jaguars (6-4) are on their way to State Farm Stadium on Sunday where they will attempt to beat the Arizona Cardinals (3-7). Jacksonville is 2.5-point favorites from oddsmakers. The betting total comes in at 47.5.

The Jacksonville Jaguars step onto the field holding a record of 6-4 on the season. In their last game, the Jaguars stepped onto the field against the Los Angeles Chargers and earned the victory with a final of 35-6. Travis Etienne was the best rusher for the Jaguars with 19 attempts for 73 yds (3.8 yds per carry). Jakobi Meyers had an average of 12.8 yds per catch by recording 64 yards on 5 receptions. Trevor Lawrence went 14-22 with 153 yds through the air and 1 TD. He had a QB rate of 80.3 and ended the contest with 1 pick. On the ground, the Jaguars conceded 42 yards on 16 attempts, which calculates to 2.6 yards per run allowed. Jacksonville conceded 13 completions on 26 attempts for a total of 93 yards, and a completion rate of 50.0%. On the day, they ran 69 plays for 345 yds. The Jacksonville Jaguars ran the ball a total of 47 different times and amassed 192 yds, earning them an average of 4.1 yards per attempt.

When you look at getting in the endzone, the AFC members are averaging 24.0 points per outing. As a unit, they're maintaining an average of 127.5 rushing yds which has them ranking 8th in football. The Jaguars have collected 3,269 yards for this campaign. Jacksonville has collected 103 first downs offensively, and they have been hurt by 84 penalties for 703 yds. They have turned the ball over 10 different times (8 INTs and 2 lost fumbles). Concerning putting points on the board, Jacksonville has tallied 11 touchdowns via the pass and 14 TD's via the ground game.

The Jaguars are ranking 12th in the league with reference to the other team scoring points, conceding 22.6 PPG. The opposition is running for 4.0 yds per rush on the ground and 86.7 rush yards per game so far this year. Concerning pass yards, the Jaguars have given up 2,369 yds, which has them sitting 24th in football. They have yielded 236.9 yds per outing by way of the pass, and are granting a completion rate of 62.1%. On the whole, they are allowing 323.6 total yards per contest, ranking them 14th in the league. They have yielded 21 touchdowns by way of the pass, along with 6 touchdowns by way of the ground game. On the whole, they have relinquished 867 yards via the ground game in 10 contests so far this season.

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The Cardinals step onto the field with a record of 3-7 so far this year. The last time they stepped on the football field, the Cardinals went home defeated by a final of 41-22 when they faced the San Francisco 49ers. Jacoby Brissett (2 touchdowns) finished the game with 452 yds on 47-57 passing while his quarterback rating was 96.8. He tossed 2 interceptions and his avg yards per attempt was 7.9 yards. Emari Demercado carried the football 5 times for 8 yards, finishing the contest with 1.6 yds per attempt for Arizona. Michael Wilson was one of the featured targets for the Cardinals, grabbing 15 passes for 185 yards (12.3 yards per catch). Arizona rushed the football for 2.6 yards per attempt, finishing the game with 36 yds on 14 carries. The Cardinals finished with 488 yds on 71 plays (6.9 yards per play). The Cardinals pass defense gave up a completion percentage of 73.1%, surrendering 186 yards on 19 out of 26 through the air. Arizona surrendered 25 rush attempts for 95 yards (3.8 yds per carry).

When it comes to putting points on the board, the Cardinals are ranked 19th in football, holding an average of 22.4 points per outing. On the season, the Cardinals have thrown for a total of 2,278 yards via the pass and are averaging 227.8 yards via the pass per contest, which is good for 12th in the league. They average 105.7 rush yards per game, and have rushed for 1,057 yards. The Arizona Cardinals average 333.5 yards per game, which has them ranking 14th in the league. The Arizona offense has allowed 570 total yards by way of 78 infractions, which is good for 7th in the league if you're looking at helping out the other team. They have compiled 6 INTs while giving up 7 lost fumbles, and have been able to tally 125 1st downs as a team.

They have yielded 13 touchdowns by way of the pass along with 221.4 yards via the pass per outing, ranking this team at 20th in the league. Arizona has relinquished a total of 1,122 running yds (112.2 yards per contest), in addition to 11 touchdowns to rushers for the year. The defense has attained 13 turnovers (7 fumbles forced and 6 interceptions) on the campaign. On the whole, they have relinquished 256 total points. The Cardinals defense has taken the field for 624 plays from the line of scrimmage, ranking this team at 16th in pro football. The Cardinals are conceding 25.6 points per contest, which has them ranking 25th in the league.

Who will win tonight's Jaguars-Cardinals NFL game against the spread?

Tony's Pick: Take the Cardinals +2.5

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