Jacksonville Jaguars vs Denver Broncos Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16

Game: Jacksonville Jaguars vs Denver Broncos

Date: Sunday, December 21, 2025

Location: Empower Field at Mile High in Denver, CO

TV: FOX

Odds-Point Spread: Broncos (-3)

Total-Over-Under: 46.5

The Denver Broncos (12-2) will take on the Jacksonville Jaguars (10-4) at Empower Field at Mile High on Sunday. Denver opens this game as 3-point favorites from Vegas oddsmakers. The total is set at 46.5.

The Jacksonville Jaguars step on the gridiron holding a record of 10-4 this year. When they last took the field, the Jaguars took the field against the New York Jets and went home with a win by a final score of 48-20. Trevor Lawrence led the offense in rushing for the Jaguars with 5 attempts for 51 yds (10.2 yds per carry). Jakobi Meyers left with an average of 14.2 yards per reception by earning 71 yards on 5 catches. Trevor Lawrence went 20-32 with 330 yds passing and 5 TDs. He had a quarterback rate of 136.7 and finished the game without throwing an interception. When it came to stopping the run, the Jaguars gave up 130 yds on 32 tries, which is an average of 4.1 yards per rush surrendered. Jacksonville conceded 22 completions on 33 tries for a total of 154 yds, and a completion rate of 66.7%. Overall, they ran 59 plays which gave them 438 yds. The Jacksonville Jaguars ran the rock 27 times and recorded 108 yds, earning them an average of 4.0 yds per carry.

The Jaguars have earned 4,700 total yards this year. Jacksonville has attained 155 1st downs, and they have been hurt by 117 penalties for 985 yds. When examining getting the ball into the endzone, Jacksonville has accumulated 23 passing TD's and 18 running touchdowns. They have given the ball away 16 times (11 picks and 5 fumbles lost). Offensively, they average 120.7 rushing yards which is good for 16th in the league. If you're looking at getting the ball in the endzone, the Jacksonville Jaguars are averaging 26.9 PPG.

When examining yards via the pass, the Jaguars have relinquished 3,111 yds, giving them a rank of 20th in the league. They have given up 222.2 yards per game through the air, and are conceding a completion rate of 63.2%. In total, they have granted 1,208 yards via the running game in 14 matchups this year. They have relinquished 23 touchdowns through the air, in addition to 10 touchdowns by way of the ground game. Overall, they are surrendering 308.5 total yards per contest, which ranks 10th in the league. They are allowing teams to run for an average of 3.9 yds per run and 86.3 rush yds per contest on the season. The Jaguars sit 10th in the league in terms of their defensive prowess, relinquishing 20.9 points per outing.

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The Broncos head into this matchup 12-2 on the year. The last time they stepped on the gridiron, the Broncos went home victorious with a score of 34-26 when they played the Green Bay Packers. Bo Nix (4 touchdowns) finished the game with 302 yards on 23-34 through the air while his QB rating was 134.7. He didn't throw any interceptions and his Y-A was 8.9 yards. RJ Harvey carried the football 19 times for 65 yds, finishing the game with 3.4 yds per carry for Denver. Courtland Sutton was featured in the passing game for the Broncos, bringing in 7 throws for 113 yds (16.1 yds per reception). Denver rushed for 2.9 yards per tote, finishing the contest with 89 yds on 31 attempts. The Broncos ended up finishing with 391 yds on 65 plays (6.0 yards per play). The Broncos pass defense allowed a completion percentage of 60.0%, relinquishing 247 yds on 24 out of 40 through the air. Denver conceded 20 run attempts for 115 yds (5.8 yards per rush).

The Denver Broncos maintain an average of 345.5 yards per contest, which has them ranked 11th in professional football. They maintain an average of 119.5 running yards per game, and have carried the ball for 1,673 yards. They have recorded 9 interceptions while conceding 5 fumbles, and have earned 164 1st downs as a team. The Denver offense has conceded 1,026 yards on 112 penalties, which has them ranked 2nd in professional football with reference to helping out the opposition. On the year, the Broncos have thrown for 3,164 yards through the air and are sitting at 226.0 yards through the air per game, ranking this team at 11th in pro football. When you look at putting points on the board, the Broncos currently sit 12th in the league, by scoring 24.4 points per game.

The Broncos are giving up 18.6 points per outing, giving them a rank of 4th in professional football. They have given up 14 touchdowns through the air in addition to 196.9 yards through the air per game, ranking this team at 11th in pro football. Denver has allowed a total of 1,272 rushing yards (90.9 yds per contest), plus 10 touchdowns via the ground game for this campaign. The Broncos defense has participated in 882 plays, ranking this team at 23rd in football. The defense has accumulated 12 turnovers (3 fumbles forced and 9 INTs) on the campaign. Altogether, they have conceded 261 pts.

Who will win tonight's Jaguars-Broncos NFL game against the spread?

Guy's Pick: Take the Jaguars +3

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