Jacksonville Jaguars vs Indianapolis Colts Prediction, 12/28/2025 NFL Picks, Best Bets & Odds Week 17

Game: Jacksonville Jaguars vs Indianapolis Colts

Date: Sunday, December 28, 2025

Location: Lucas Oil Stadium in Indianapolis, IN

TV: FOX

Odds-Point Spread: Colts (+6.5)

Total-Over-Under: 48.5

The Jacksonville Jaguars (11-4) are traveling to Lucas Oil Stadium on Sunday where they will go up against the Indianapolis Colts (8-7). Jacksonville opens as 6.5-point favorites from Vegas oddsmakers. The total comes in at 48.5.

The Jacksonville Jaguars step on the gridiron holding a record of 11-4 on the year. The last time they took the field, the Jaguars played the Denver Broncos and walked away with a win by a score of 34-20. Trevor Lawrence finished 23-36 with 279 yards passing and 3 touchdowns. He had a quarterback rating of 115.4 and ended the game with no picks. Travis Etienne led the offense in rushing for the Jaguars with 16 carries for 50 yds (3.1 yds per carry). Parker Washington left with an average of 24.2 yds per catch by totaling 145 yds on 6 catches. The Jacksonville Jaguars ran the football 27 different times and totaled 81 yards, which had them averaging 3.0 yards per tote. At the end of the game, they ran 63 plays which gave them a total of 346 yards. Jacksonville surrendered 28 pass completions on 47 attempts for a total of 344 yards, and a completion percentage of 59.6%. When it came to stopping the run, the Jaguars conceded 101 yards on 17 tries, which is 5.9 yds per run allowed.

The Jaguars have earned 5,046 yds for the season. Jacksonville has racked up 167 first downs as a unit, and they have been hurt by 119 infractions for 1005 yards. When examining putting the ball in the endzone, Jacksonville has earned 26 passing touchdowns and 19 ground TD's. They have coughed up the ball 16 different times (11 picks and 5 fumbles). As a team, they're maintaining an average of 118.1 rush yds which has them ranking 19th in professional football. When it comes to putting the ball in the endzone, the group residing in Jacksonville are sitting at 27.3 points per contest.

When you look at yards via the pass, the Jaguars have allowed 3,455 yards, which is good for 24th in football. They have allowed 230.3 yards per contest via the pass, and are surrendering a completion percentage of 62.9%. In total, they have conceded 1,309 rushing yards through 15 games over the course of this year. They have given up 24 touchdowns through the air, plus 11 touchdowns to rushers. In total, they are surrendering 317.6 yards per game, which is 13th in pro football. The opposition is running for an average of 4.0 yards per running attempt and 87.3 rushing yards per contest this season. The Jaguars are ranked 10th in football if you examine the other team scoring points, allowing 20.8 points per game.

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The Colts step on the gridiron with a record of 8-7 on the campaign. When they last took the field, the Colts took a loss by a final score of 48-27 against the San Francisco 49ers. Jonathan Taylor ran the ball 16 times for 46 yards, ending the contest with 2.9 yds per carry for Indianapolis. Josh Downs was featured in the passing game for the Colts, catching 5 balls for 65 yds (13.0 yards per catch). Philip Rivers (2 TDs) ended the contest with 277 yards on 23-35 through the air while his QB rating was 97. He threw 1 interception and his average yds per pass attempt was 7.9 yds. Indianapolis gave up 31 rush attempts for 145 yards (4.7 yards per rush). The Colts pass defense conceded a completion rate of 73.5%, relinquishing 295 yards on 25 out of 34 passing. The Colts finished the game with a total of 312 yds while running 56 plays (5.6 yds per play). Indianapolis ended up running for 2.9 yds per carry, totaling 58 yards on 20 carries.

The Indianapolis Colts maintain an average of 354.8 yards per contest, which is good for 8th in the NFL. They average 124.1 rushing yds per game, and have rushed for 1,862 yds. They have compiled 11 INTs while giving up 7 lost fumbles, and have tallied 179 first downs. The Indianapolis offense has allowed 744 yards by way of 92 penalties, which has them sitting 23rd in football if you examine giving up free yards. Over the course of this season, the Colts have earned 3,460 yards via the pass and hold an average of 230.7 yards via the pass per game, which is good for 11th in football. When examining the points being put on the board, the Colts are ranked 6th in professional football, scoring 27.9 points per game.

The Colts are conceding 23.4 points per outing, which is good for 18th in the NFL. They have given up 23 touchdowns through the air plus 250.7 yards through the air per game, which has them sitting 31st in football. Indianapolis has yielded a total of 1,477 rushing yds (98.5 yards per contest), along with 13 touchdowns to rushers on the campaign. The Colts defense has participated in 982 plays from scrimmage, which has them sitting 31st in the league. Their defense has earned 19 turnovers (6 forced fumbles and 13 picks) on the campaign. On the whole, they have relinquished 351 points.

Who will win tonight's Jaguars-Colts NFL game against the spread?

Josh's Pick: Take the Colts +6.5

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