Kansas City Chiefs vs New York Giants Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3

Game: Kansas City Chiefs vs New York Giants

Date: Sunday, September 21, 2025

Location: MetLife Stadium in East Rutherford, NJ

TV: NBC

Odds-Point Spread: Giants (+5.5)

Total-Over-Under: 45.5

The Kansas City Chiefs (0-2) are headed to MetLife Stadium on Sunday where they will attempt to defeat the New York Giants (0-2). Kansas City opens this matchup as 5.5-point favorites from oddsmakers. The total has been set at 45.5.

The Kansas City Chiefs step on the gridiron 0-2 so far this season. The last time they stepped on the gridiron, the Chiefs played the Philadelphia Eagles and took a loss by a score of 20-17. Patrick Mahomes went 16-29 with 187 yards through the air and 1 touchdown. He had a QB rating of 72.1 and ended the contest with 1 interception. Patrick Mahomes was the rushing leader for the Chiefs with 7 carries for 66 yards (9.4 yds per attempt). Travis Kelce held an average of 15.3 yards per catch by totaling 61 yds on 4 receptions. The Kansas City Chiefs ran the rock 26 times and accumulated 121 yds, which is an average of 4.7 yards per tote. At the end of the game, they tallied 55 plays which gave them a total of 294 yds. Kansas City gave up 15 completions on 22 tries for a total of 94 yards, and a completion percentage of 68.2%. Against the rush, the Chiefs gave up 122 yards on 34 attempts, which is an average of 3.6 yds per run allowed.

With reference to scoring touchdowns, the Kansas City Chiefs hold an average of 19.0 points per contest. Offensively, they're maintaining an average of 109.5 rushing yds ranking them 17th in the NFL. The Chiefs have notched 641 yds for the year. Kansas City has accrued 16 first downs, and they have been hurt by 16 infractions for 116 yds. They have given the ball to the opposition 1 time. Concerning putting points on the board, Kansas City has accrued 2 passing touchdowns and 2 touchdowns via the run.

The Chiefs are ranking 20th in professional football when analyzing team defense, conceding 23.5 PPG. They are allowing teams to run for an average of 3.6 yards per rushing attempt and 106.0 running yds per outing so far this season. Concerning yards via the pass, the Chiefs have allowed 398 yds, putting them 15th in pro football. They have allowed 199.0 yds per outing through the air, and are surrendering a completion rate of 71.4%. All in all, they are giving up 305.0 yards per contest, ranking them 13th in the NFL. They have allowed 3 touchdowns by way of the pass, along with 2 touchdowns via the rush. Overall, they have conceded 212 yards via the ground game in 2 contests so far this season.

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The Giants step on the gridiron with a record of 0-2 over the course of the season. The last time they stepped on the football field, the Giants walked away with a loss by a score of 40-37 when they faced the Dallas Cowboys. Cam Skattebo carried the rock 11 times for 45 yds, finishing the game with 4.1 yds per attempt for New York. Malik Nabers was one of the featured targets for the Giants, snagging 9 passes for 167 yds (18.6 yds per catch). Russell Wilson (3 touchdowns) ended the contest with 450 yds on 30-41 passing while his QB rating was 123. He threw 1 pick and his avg yards per attempt was 11.0 yards. New York relinquished 28 attempts on the ground for 135 yds (4.8 yards per carry). The Giants pass defense conceded a completion rate of 73.1%, surrendering 343 yds on 38 out of 52 passing. The Giants ended up finishing with 506 yds on 62 plays (8.2 yards per play). New York ended up running for 4.0 yards per tote, finishing with a total of 84 yds on 21 attempts.

The New York Giants have an average of 368.5 yards per contest, ranking them 6th in the NFL. They hold an average of 79.0 rushing yds per outing, and have run for 158 yds. They have been able to record 24 first downs as a unit. The New York offense has relinquished 195 yards on 20 violations, ranking them 5th in football concerning making mistakes. In this campaign, the Giants have racked up 579 yards via the pass and have an average of 289.5 yards via the pass per game, ranking them 1st in football. When talking about putting points on the board, the Giants are ranking 19th in professional football, holding an average of 21.5 PPG.

The Giants are granting 30.5 PPG, which is good for 27th in football. They have allowed 3 touchdowns by way of the pass along with 277.5 pass yards per contest, ranking them 29th in the NFL. New York has yielded a total of 355 rush yards (177.5 yards per game), along with 4 touchdowns via the ground game over the course of the season. The Giants defense has been on the field for 148 plays, which is good for 31st in football. The D has recorded 1 turnover. Altogether, they have relinquished 61 total points.

Who will win tonight's Chiefs-Giants NFL game against the spread?

Josh's Pick: Take the Chiefs -5.5

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